Yıl 2021, Cilt 60 , Sayı 1, Sayfalar 63 - 69 2021-03-31

Nötrofil lenfosit oranı: Papiller tiroit kanserini multinodüler guatrdan gerçekten ayırt eder mi?
Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter

Hakan BÖLÜKBAŞI [1] , Serhan YILMAZ [2]


Amaç: Bu çalışmanın amacı, preoperatif nötrofil lenfosit oranının papiller tiroit karsinomu, papiller tiroit mikrokarsinomu ve benign multinodüler guatr arasında ayırıcı tanıdaki değerini ortaya koymaktır. Metod: Çalışmaya, total tiroidektomi uygulanan ve histopatolojik tanıları postoperatif patoloji raporları ile doğrulanan papiller tiroit karsinomu, papiller tiroit mikrokarsinomu ve multinodüler guatr hastaları dahil edildi. Bulgular: Ortalama TSH düzeyi papiller tiroit karsinomu grubunda 1.85 ± 1.18 mIU / L, papiller tiroit mikrokarsinomu grubunda 1.78 ± 1.04 mIU / L ve multinodüler guatr grubunda 1.15 ± 0.91 mIU / L idi. TSH düzeyleri gruplar arasında istatistiksel olarak anlamlı farklıydı (p <0,001). Gruplar arası karşılaştırma, multinodüler guatr grubunda TSH seviyelerinin papiller tiroit karsinomu ve papiller tiroit mikrokarsinomu gruplarına kıyasla önemli ölçüde daha düşük olduğunu ortaya çıkardı (p <0.001, p0.001). Ortalama nötrofil sayısı papiller tiroit karsinomu grubunda 4,98 ± 1,19, papiller tiroit mikrokarsinomu grubunda 4,68 ± 1,33 ve multinodüler guatr grubunda 4,59 ± 1,40 idi. Grupların nötrofil sayıları anlamlı olarak farklı bulundu (p = 0,013). Papiller tiroit karsinomu grubu, multinodüler guatr grubuna göre önemli ölçüde daha yüksek nötrofil sayısına sahipti Ortalama nötrofil lenfosit oranı, papiller tiroit karsinomu grubunda 2.20 ± 0.71 ve multinodüler guatr grubunda 2.02 ± 0.92 idi. Nötrofil lenfosit oranı papiller tiroit karsinomu grubunda anlamlı olarak yüksekti (p = 0,006). Sonuç: Ameliyat öncesi dönemde tiroit nodülü olan hastalarda nötrofil lenfosit oranı artışının altta yatan kötü huylu hastalığın bir göstergesi olabileceğine inanıyoruz.
Aim: The aim of this study is to reveal the value of preoperative neutrophil lymphocyte ratio in differential diagnosis between papillary thyroid carcinoma, papillary thyroid microcarcinoma and benign multinodular goiter. Materials and methods: Patients with papillary thyroid carcinoma, papillary thyroid microcarcinoma, and multinodular goiter whose histopathological diagnosis was confirmed by postoperative pathology reports were included in the study. Results: The TSH levels were statistically significantly different among the groups (p < 0.001). The intergroup comparison revealed that the TSH levels were significantly lower in the multinodular goiter group compared to the papillary thyroid carcinoma and papillary thyroid microcarcinoma groups (p < 0.001, p0.001). The mean neutrophil count was 4.98 ± 1.19 in the papillary thyroid carcinoma group, 4.68 ± 1.33 in the papillary thyroid microcarcinoma group, and 4.59 ± 1.40 in the multinodular goiter group. The neutrophil counts of the groups were found to be significantly different (p = 0.013). The papillary thyroid carcinoma group had a significantly higher neutrophil count than the multinodular goiter group. The mean Neutrophil lymphocyte ratio value was 2.20 ± 0.71 in the papillary thyroid carcinoma group and 2.02 ± 0.92 in the multinodular goiter group. Neutrophil lymphocyte ratio values were significantly higher in the the papillary thyroid carcinoma group (p = 0.006). Conclucion: We believe that increased neutrophil lymphocyte ratio may be an indicator of underlying malignant disease in patients with thyroid nodules in the preoperative period.
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Birincil Dil en
Konular Sağlık Bilimleri ve Hizmetleri
Bölüm Araştırma Makaleleri
Yazarlar

Orcid: 0000-0002-4904-9302
Yazar: Hakan BÖLÜKBAŞI (Sorumlu Yazar)
Kurum: University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, General Surgery, Istanbul, Turkey
Ülke: Turkey


Orcid: 0000-0002-5612-5932
Yazar: Serhan YILMAZ
Kurum: University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, General Surgery, Istanbul, Turkey
Ülke: Turkey


Tarihler

Başvuru Tarihi : 20 Ekim 2020
Kabul Tarihi : 16 Aralık 2020
Yayımlanma Tarihi : 31 Mart 2021

Bibtex @araştırma makalesi { etd888863, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege Üniversitesi}, year = {2021}, volume = {60}, pages = {63 - 69}, doi = {10.19161/etd.888863}, title = {Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter}, key = {cite}, author = {Bölükbaşı, Hakan and Yılmaz, Serhan} }
APA Bölükbaşı, H , Yılmaz, S . (2021). Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter . Ege Tıp Dergisi , 60 (1) , 63-69 . DOI: 10.19161/etd.888863
MLA Bölükbaşı, H , Yılmaz, S . "Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter" . Ege Tıp Dergisi 60 (2021 ): 63-69 <http://egetipdergisi.com.tr/tr/pub/issue/60217/888863>
Chicago Bölükbaşı, H , Yılmaz, S . "Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter". Ege Tıp Dergisi 60 (2021 ): 63-69
RIS TY - JOUR T1 - Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter AU - Hakan Bölükbaşı , Serhan Yılmaz Y1 - 2021 PY - 2021 N1 - doi: 10.19161/etd.888863 DO - 10.19161/etd.888863 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 63 EP - 69 VL - 60 IS - 1 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.888863 UR - https://doi.org/10.19161/etd.888863 Y2 - 2020 ER -
EndNote %0 Ege Tıp Dergisi Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter %A Hakan Bölükbaşı , Serhan Yılmaz %T Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter %D 2021 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 60 %N 1 %R doi: 10.19161/etd.888863 %U 10.19161/etd.888863
ISNAD Bölükbaşı, Hakan , Yılmaz, Serhan . "Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter". Ege Tıp Dergisi 60 / 1 (Mart 2021): 63-69 . https://doi.org/10.19161/etd.888863
AMA Bölükbaşı H , Yılmaz S . Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter. ETD. 2021; 60(1): 63-69.
Vancouver Bölükbaşı H , Yılmaz S . Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter. Ege Tıp Dergisi. 2021; 60(1): 63-69.
IEEE H. Bölükbaşı ve S. Yılmaz , "Neutrophil to iymphocyte ratio: Does it really differentiate between papillary thyroid carcinomas and multinodular goiter", Ege Tıp Dergisi, c. 60, sayı. 1, ss. 63-69, Mar. 2021, doi:10.19161/etd.888863