Araştırma Makalesi
Yıl 2016,
Cilt: 7 Sayı: 1, 73 - 77, 01.03.2016
Öz
Kaynakça
- 1. Robertson LA, Evans CJ, Lee AJ, et al. Incidence and risk factors for venous reflux in the general population: Edinburgh Vein Study. Eur J Vasc Endovasc Surg 2014:48:208- 214.
- 2. Piazza G. Varicose veins. Circulation. 2014;130:582-587.
- 3. Akbulut B, Tok M, Uçar Hİ, Durukan B, Böke E. Venöz sistem hastalıkları: görülme sıklığı, risk faktörleri ve tedavi. AJCI 2009: 3:113-119.
- 4. Konoeda H, Yamaki T, Hamahata A, et al. Quantification of superficial venous reflux by duplex ultrasound-role of reflux velocity in the assessment the clinical stage of chronic venous insufficiency. Ann Vasc Dis 2014;7:376-382.
- 5. Bergan JJ, Pascarella L, Schmid-Schonbein GW. Pathogenesis of Primary Chronic Venos Disease: Insights from animal model of venous hypertension. J Vasc Surg. 2008;47:183- 192.
- 6. Tsiara S, Elisaf M, Jagroop IA, et al. Platelets as predictors of vascular risk: Is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-190.
- 7. Karahan O, Yavuz C, Kankilic N, et al. Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency. Blood Coagul Fibrinolysis 2015 Dec 8.
- 8. Alexandru N, Georgescu A, Amuzescu M, et al. Platelet reactivity in chronic venous insufficiency. Clin Lab 2011;57:527-534.
- 9. Matic P, Jolic S, Tanaskovic S, Soldatovic I, Katsiki N, Isenovic E, Radak Dj. Chronic Venous Disease and Comorbidities. Angiology 2015 Jul;66:539-544.
- 10. Hekimsoy Z, Payzin B, Ornek T, et al. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18:173-176.
- 11. Karakan S, Siren S. Yeni tanı hipertansif hastalarda ortalama trombosit hacmi ve arteriyel sertlik ilişkisi. Fırat Tıp Derg / Firat Med J 2014;19:189-192.
- 12. Soydinc S, Turkbeyler IH, Pehlivan Y, et al. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation 2014;37:100-106.
- 13. Khandekar MM, Khurana AS, Deshmukh SD, et al. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006;59:146-149.
- 14. Davies AH, Lees TA. Venous Disease Simplified. Arıncı H, Çev Ed. Venöz Hastalıklara Temel Yaklaşım. Birinci Baskı. İstanbul: Zeta Yayıncılık 2009.
- 15. Bromen K, Pannier-Fischer F, Stang A, et al. Should sex specific differences in venous diseases be explained by pregnancies and hormone intake? Gesundheitswesen 2004;66:170-174.
- 16. Corrasco OF, Ranero A, Hong E, Vidrio H. Endothelial function impairment in chronic venous insufficiency: Effect of some cardiovascular protectant agents. Angiology 2009;60:763-771.
- 17. Vlajinac H, Marinkovic J, Maksimovic M, Radak Dj. Factors related to venous ulceration: a cross-sectional study. Angiology 2014;65:824-830.
- 18. Uçar M, Vatansever F, Tanık N, ve ark. Karpal tünel sendromu olan hastalarda ortalama trombosit hacmi ve diğer hemogram sonuçlarının karşılaştırılması. J Clin Exp Invest 2015;6.2.
- 19. Erden EŞ, Yengil E, Tuncel E, et al. Obstrüktif uyku apne sendromu ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. J Clin Exp Invest 2013;4.4.
- 20. Madan SA, John F, Pitchumoni CS. Nonalcoholic Fatty Liver Disease and Mean Platelet Volume: A Systemic Review and Meta-analysis. J Clin Gastroenterol 2016;50:69-74.
Yıl 2016,
Cilt: 7 Sayı: 1, 73 - 77, 01.03.2016
Öz
Objective: the mean platelet volume (MPV) is a good indicator of platelet activity; it is reported to increase in diseases
associated with inflammatory processes and in vascular diseases. This study investigated the importance of mean platelet
volume in patients with chronic venous insufficiency (CVI) and whether the MPV was likely to be a predictor of the
CVI.
Methods: 117 patients who were diagnosed as CVI by colored Doppler Ultrasound (CDU) method and 49 healthy volunteers
(forming the control group) were enrolled to this study, which was planned retrospectively. The patients’ blood
count values taken within one month before and after the CDU evaluation were recorded by the hospital information
system. The complete blood count, routine biochemical tests and thyroid function tests of the patients diagnosed with
CVI were compared to the control group.
Results: Significant differences were not detected between the patients and the control group in terms of the levels
of creatinine, aspartate aminotransferase, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, erythrocyte,
sedimentation speed, leukocyte, haemoglobin and thrombocyte (p>0.05). The thyroid stimulating hormone and the
MPV levels were significantly lower in the control group (p<0.05).
Conclusion: MPV levels as an easy, cheap and practical data extracted from complete blood count, were found higher
in patients diagnosed with CVI compared to the control group. This may be originated from endothelium changes as
an answer to venous hypertension and dilatation in CVI. MPV can be used as a follow-up marker in CVI patients. J Clin
Exp Invest 2016; 7 (1): 73-77
Anahtar Kelimeler
Kaynakça
- 1. Robertson LA, Evans CJ, Lee AJ, et al. Incidence and risk factors for venous reflux in the general population: Edinburgh Vein Study. Eur J Vasc Endovasc Surg 2014:48:208- 214.
- 2. Piazza G. Varicose veins. Circulation. 2014;130:582-587.
- 3. Akbulut B, Tok M, Uçar Hİ, Durukan B, Böke E. Venöz sistem hastalıkları: görülme sıklığı, risk faktörleri ve tedavi. AJCI 2009: 3:113-119.
- 4. Konoeda H, Yamaki T, Hamahata A, et al. Quantification of superficial venous reflux by duplex ultrasound-role of reflux velocity in the assessment the clinical stage of chronic venous insufficiency. Ann Vasc Dis 2014;7:376-382.
- 5. Bergan JJ, Pascarella L, Schmid-Schonbein GW. Pathogenesis of Primary Chronic Venos Disease: Insights from animal model of venous hypertension. J Vasc Surg. 2008;47:183- 192.
- 6. Tsiara S, Elisaf M, Jagroop IA, et al. Platelets as predictors of vascular risk: Is there a practical index of platelet activity? Clin Appl Thromb Hemost 2003;9:177-190.
- 7. Karahan O, Yavuz C, Kankilic N, et al. Simple blood tests as predictive markers of disease severity and clinical condition in patients with venous insufficiency. Blood Coagul Fibrinolysis 2015 Dec 8.
- 8. Alexandru N, Georgescu A, Amuzescu M, et al. Platelet reactivity in chronic venous insufficiency. Clin Lab 2011;57:527-534.
- 9. Matic P, Jolic S, Tanaskovic S, Soldatovic I, Katsiki N, Isenovic E, Radak Dj. Chronic Venous Disease and Comorbidities. Angiology 2015 Jul;66:539-544.
- 10. Hekimsoy Z, Payzin B, Ornek T, et al. Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications 2004;18:173-176.
- 11. Karakan S, Siren S. Yeni tanı hipertansif hastalarda ortalama trombosit hacmi ve arteriyel sertlik ilişkisi. Fırat Tıp Derg / Firat Med J 2014;19:189-192.
- 12. Soydinc S, Turkbeyler IH, Pehlivan Y, et al. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation 2014;37:100-106.
- 13. Khandekar MM, Khurana AS, Deshmukh SD, et al. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: an Indian scenario. J Clin Pathol 2006;59:146-149.
- 14. Davies AH, Lees TA. Venous Disease Simplified. Arıncı H, Çev Ed. Venöz Hastalıklara Temel Yaklaşım. Birinci Baskı. İstanbul: Zeta Yayıncılık 2009.
- 15. Bromen K, Pannier-Fischer F, Stang A, et al. Should sex specific differences in venous diseases be explained by pregnancies and hormone intake? Gesundheitswesen 2004;66:170-174.
- 16. Corrasco OF, Ranero A, Hong E, Vidrio H. Endothelial function impairment in chronic venous insufficiency: Effect of some cardiovascular protectant agents. Angiology 2009;60:763-771.
- 17. Vlajinac H, Marinkovic J, Maksimovic M, Radak Dj. Factors related to venous ulceration: a cross-sectional study. Angiology 2014;65:824-830.
- 18. Uçar M, Vatansever F, Tanık N, ve ark. Karpal tünel sendromu olan hastalarda ortalama trombosit hacmi ve diğer hemogram sonuçlarının karşılaştırılması. J Clin Exp Invest 2015;6.2.
- 19. Erden EŞ, Yengil E, Tuncel E, et al. Obstrüktif uyku apne sendromu ile ortalama trombosit hacmi arasındaki ilişkinin incelenmesi. J Clin Exp Invest 2013;4.4.
- 20. Madan SA, John F, Pitchumoni CS. Nonalcoholic Fatty Liver Disease and Mean Platelet Volume: A Systemic Review and Meta-analysis. J Clin Gastroenterol 2016;50:69-74.
Toplam 20 adet kaynakça vardır.
Ayrıntılar
| Konular | Sağlık Kurumları Yönetimi |
|---|---|
| Bölüm | Araştırma Yazısı |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2016 |
| Yayımlandığı Sayı | Yıl 2016 Cilt: 7 Sayı: 1 |