Journal of Contemporary Medicine

Öz

Backgrounds: Carbon monoxide (CO) is an odorless and colorless gas that forms when organic materials burn incompletely. Children are more susceptible to CO poisoning than adults because their respiratory and immune systems are still developing. The systemic immune inflammation index (SII) is a marker that reflects the balance between inflammation and immunity.
Aims: In this study, we investigate the relationship between CO poisoning in children and SII.
Materials and Methods: We conducted a retrospective observational study involving pediatric patients (age <18 years) diagnosed with CO poisoning and treated at XXX University Training and Research Hospital, a tertiary medical center, from January 2018 to January 2023. We included consecutive pediatric patients (age <18 years) with CO poisoning who had available clinical and laboratory data and were treated at our hospital.
Results: The study included 393 patients with a mean age of 7.24 (± 4.67) years, of whom 184 (46.8%) were male. When comparing COHb groups, significant statistical differences emerged between the groups regarding GCS, pH levels, occurrences of dizziness, confusion, seizures, lethargy, and prognosis (p<0.05). When comparing lactate groups, significant differences were observed between the groups concerning GCS, COHb levels, pH levels, occurrences of confusion, lethargy, prognosis, and LOS (p<0.05). Upon evaluating the SII, no statistically significant difference was found between the groups in terms of gender, COHb levels, lactate levels, LOS, and prognosis.
Conclusion: SII cannot be considered a reliable predictor of the severity of carbon monoxide poisoning in children. Despite the evident inflammatory response triggered by exposure to carbon monoxide, the SII did not consistently correlate with the varying degrees of poisoning severity.