Öz
Kaynakça
- 1- Kaur S. Baine MJ. Jain M. Sasson AR. Batra SK. Early diagnosis of pancreatic cancer: challenges and new developments. Biomark Med 2012; 6: 597-612.
- 2- Steer ML, Waxman I, Freedman S. Chronic pancreatitis. N Engl J Med 1995; 332: 1482-90.
- 3- Yeo TP, Lowenfels AB. Demographics and epidemiology of pancreatic cancer. Cancer J 2012 ;18: 477-84.
- 4- Dítě P, Hermanová M, Trna J, et al.The role of chronic inflammation: chronic pancreatitis as a risk factor of pancreatic cancer. Dig Dis 2012;30: 277-83.
- 5- Kuramochi H, Nakajima G, Kaneko Y,et al. Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. BMC Cancer 2012; 12: 88.
- 6- Busser B, Sancey L, Brambilla E, Coll JL, Hurbin A .The multiple roles of amphiregulin in human cancer. Biochi Biophys Acta 2011; 1816: 119-31.
- 7- Yadav D, Hawes RH, Brand RE, et al. North American Pancreatic Study Group. Alcohol cosumption, cigarette smoking, and the risk of recurrent acute end chronic pancreatitis. Arch Intern Med 2009 ; 169 : 1035-45.
- 8- Hirota M, Shimosegawa T, Masamune A , et al. The sixth nationwide epidemiological survey of chronic pancreatitis in Japan. Pancreatology 2012 ;12: 79-84.
- 9- Herreros-Villanueva M, Hijona E, Banales JM, Cosme A. Bujande L. Alcohol consumption on pancreatic diseases.Worl J Gastroenterol 2012; 19 : 638- 47.
- 10- DiMango MJ, DiMango EP. Chronic pancreatitis. Curr Opin Gastroenterol 2012; 28 : 523-31.
- 11- Wang W, Guo Y, Liao Z. Occurrence of an risk factors for diabetes mellitus in Chinese patients with chronic pancreatitis. Pancreas 2011; 40: 206-12.
- 12- Lai HC, Tsai IJ, Chen PC, et al. Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study. J Gastroenterol. 2013; 48: 721-7.
- 13- Michalopoulos G, Khan Z. Liver Regeneretion, Growth Factors, and amphiregulin. Gastroenterology 2005; 128 : 503-6.
- 14- Pei R, Chen H, Lu L, et al.Hepatitis C virüs infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathway and requared for efficient viral assembly. J Gen Virol 2011; 92: 2237–48.
- 15- Johansson CC, Yndestad A, Enserink JM, et al. The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3’5’-monophosphate pathway in various cell types. Endocrinology 2004 ;145: 5177-84.
- 16- Tun MT, Pai RK, Kwok S, et al. Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts. BMC Gastroenterol 2012; 12: 15.
Serum amphiregulin level and pancreatic adenocarcinoma relation in patients with chronic pancreatitis
Öz
Background /Aims : We aimed
in our study to determine serum amphiregulin level, which is an indicator of a
malignancy, and to foresee pancreatic carcinoma in chronic pancreatitis.
Materials
and Methods: 42 patients who applied to Department of Gastroenterology and were diagnosed with chronic
pancreatitis and 43 healthy patients as
the control group were enrolled in the study. Serum amphiregulin levels were
studied with an Amphiregulin Human ELISA Kit ab99975 (Abcam, Cambridge, UK) by
ELISA(Enzyme-Linked Immunosorbent Assay) method.
Results:
Patients with chronic pancreatitis compared to healthy control group (p : 0.007)
and the group complicated with pseudocyst among chronic pancreatitis patient
group, serum amphiregulin level (p : 0.006) and Ca 19-9 (p : 0.03) level are
high. We also found that the relationship between the long diameter of the
pseudocyst and serum amphiregulin level is statistically significant (p : 0.01)
in the complicated chronic pancreatitis group.
Conclusion:
Patients with chronic pancreatitis and the group complicated with pseudocyst
among chronic pancreatitis patient group must be monitored more closely in
terms of pancreatic cancer since serum amphiregulin level and Ca 19-9 level are
high and the relationship between the long diameter of the pseudocyst and serum
amphiregulin level is statistically significant in such patient groups.
Anahtar Kelimeler
Kaynakça
- 1- Kaur S. Baine MJ. Jain M. Sasson AR. Batra SK. Early diagnosis of pancreatic cancer: challenges and new developments. Biomark Med 2012; 6: 597-612.
- 2- Steer ML, Waxman I, Freedman S. Chronic pancreatitis. N Engl J Med 1995; 332: 1482-90.
- 3- Yeo TP, Lowenfels AB. Demographics and epidemiology of pancreatic cancer. Cancer J 2012 ;18: 477-84.
- 4- Dítě P, Hermanová M, Trna J, et al.The role of chronic inflammation: chronic pancreatitis as a risk factor of pancreatic cancer. Dig Dis 2012;30: 277-83.
- 5- Kuramochi H, Nakajima G, Kaneko Y,et al. Amphiregulin and Epiregulin mRNA expression in primary colorectal cancer and corresponding liver metastases. BMC Cancer 2012; 12: 88.
- 6- Busser B, Sancey L, Brambilla E, Coll JL, Hurbin A .The multiple roles of amphiregulin in human cancer. Biochi Biophys Acta 2011; 1816: 119-31.
- 7- Yadav D, Hawes RH, Brand RE, et al. North American Pancreatic Study Group. Alcohol cosumption, cigarette smoking, and the risk of recurrent acute end chronic pancreatitis. Arch Intern Med 2009 ; 169 : 1035-45.
- 8- Hirota M, Shimosegawa T, Masamune A , et al. The sixth nationwide epidemiological survey of chronic pancreatitis in Japan. Pancreatology 2012 ;12: 79-84.
- 9- Herreros-Villanueva M, Hijona E, Banales JM, Cosme A. Bujande L. Alcohol consumption on pancreatic diseases.Worl J Gastroenterol 2012; 19 : 638- 47.
- 10- DiMango MJ, DiMango EP. Chronic pancreatitis. Curr Opin Gastroenterol 2012; 28 : 523-31.
- 11- Wang W, Guo Y, Liao Z. Occurrence of an risk factors for diabetes mellitus in Chinese patients with chronic pancreatitis. Pancreas 2011; 40: 206-12.
- 12- Lai HC, Tsai IJ, Chen PC, et al. Gallstones, a cholecystectomy, chronic pancreatitis, and the risk of subsequent pancreatic cancer in diabetic patients: a population-based cohort study. J Gastroenterol. 2013; 48: 721-7.
- 13- Michalopoulos G, Khan Z. Liver Regeneretion, Growth Factors, and amphiregulin. Gastroenterology 2005; 128 : 503-6.
- 14- Pei R, Chen H, Lu L, et al.Hepatitis C virüs infection induces the expression of amphiregulin, a factor related to the activation of cellular survival pathway and requared for efficient viral assembly. J Gen Virol 2011; 92: 2237–48.
- 15- Johansson CC, Yndestad A, Enserink JM, et al. The epidermal growth factor-like growth factor amphiregulin is strongly induced by the adenosine 3’5’-monophosphate pathway in various cell types. Endocrinology 2004 ;145: 5177-84.
- 16- Tun MT, Pai RK, Kwok S, et al. Diagnostic accuracy of cyst fluid amphiregulin in pancreatic cysts. BMC Gastroenterol 2012; 12: 15.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Orijinal Makale |
| Yazarlar | |
| Yayımlanma Tarihi | 22 Eylül 2019 |
| Yayımlandığı Sayı | Yıl 2019 Cilt: 2 Sayı: 4 |
Üniversitelerarası Kurul (ÜAK) Eşdeğerliği: Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN]
Dahil olduğumuz İndeksler (Dizinler) ve Platformlar sayfanın en altındadır.
Not: Dergimiz WOS indeksli değildir ve bu nedenle Q olarak sınıflandırılmamıştır.
Yüksek Öğretim Kurumu (YÖK) kriterlerine göre yağmacı/şüpheli dergiler hakkındaki kararları ile yazar aydınlatma metni ve dergi ücretlendirme politikasını tarayıcınızdan indirebilirsiniz. https://dergipark.org.tr/tr/journal/2316/file/4905/show
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