Öz
Ekstramedüller plazmasitom nadir görülem plazma hücreli bir neoplazidir. Sıklıkla üst solunum yollarını tutar, göz tutulumu ise son derece nadirdir. Bu bildiride orbital kaynaklı bir ekstramedüller plazmasitom olgusu sunduk. 55 yaşında erkek hasta, sol gözde şişlik nedeniyle yapılan tetkiklerinde orbital yerleşimli 5x6 cm boyutlarında kitle tespit ediliyor. Kitlenin histopatolojik incelemesinde amiloid arasında bol miktarda plazma hücreleri izlenmiş olup kappa-lamda ile monoklonalite görülmüştür. Olgu plasma hücreli neoplazi olarak rapor edilmiş olup tetkiklerinde başka bir odak tesbit edilmediğinden soliter plasmasitom olarak kabul edilmiştir. Ekstramedüller plazmasitom orbital yerleşimli kitlelerde akılda tutulmalıdır. Prognozu farklılık gösterdiği için tanısında sistemik bir plazma hücre diskrazisinin varlığı mutlaka sorgulanmalıdır.
Anahtar Kelimeler
Destekleyen Kurum
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Proje Numarası
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Teşekkür
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Kaynakça
- Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin. 2012 2012; 62: 10–29
- Matos A, Goulart A, Ribeiro A, et al. Orbital plasmacytoma, an uncommon presentation of advanced multiple myeloma. Eur J Case Rep Intern Med 2020; 7: 001149.
- Wang SSY, Lee MB, George A, et al. Five cases of orbital extramedullary plasmacytoma: diagnosis and management of an aggressive malignancy. Orbit 2019; 38: 218-25.
- Bhadauria BM, Ranjan P, Mishra D. Primary orbital plasmacytoma mimicking lacrimal gland tumor. Orbit 2014; 33: 305–7
- Barmas-Alamdari D, Sodhi GS, Shenouda TA. Bilateral proptosis in a case of recurring multiple myeloma: uncommon orbital presentation of plasmacytoma. Int Med Case Rep J 2020; 13: 297-301.
- Sharma S, Kaur R, Bal A, Mohindra S, et al. Primary orbital plasmacytoma: An unusual presentation in an adolescent. Indian J Pathol Microbiol 2018; 61: 158-9.
- Vatansever M, Bozkurt FM, Dinç E, et al. Orbital metastasis of multiple myeloma: case report. Turk J Ophthalmol 2016; 46: 148-50.
- Bhadauria M, Ranjan P, Mishra D. Primary orbital plasmacytoma mimicking lacrimal gland tumor. Orbit 2014; 33: 305-7.
- Rodriguez T, Bon V. Secondary extramedullary bilateral orbital plasmacytoma in a 65-year-old man. J Fr Ophtalmol 2019; 42: 267-9.
- Hsu VJ, Agarwal MR, Chen CS, et al. IgA orbital plasmacytoma in multiple myeloma. Ophthalmic Plast Reconstr Surg 2010; 26: 126-7.
- Pierre-Filho, Paulo de Tarso P, do Carmo Carvalho F, et al. Orbital extramedullary plasmacytoma leading to exenteration. Can J Ophthalmol 2004; 39: 557.
- Ockrim ZK, Deutch J, Izon J. Bilateral retro-orbital plasmacytoma. Eye (Lond) 2000; 14: 795-7.
- Uceda-Montañés A, Blanco G, Saornil MA, et al. Extramedullary plasmacytoma of the orbit. Acta Ophthalmol Scand 2000; 78: 601-3.
- Liao J, Greenberg A, Shinder R. Relapsed multiple myeloma presenting as an orbital plasmacytoma. Ophthalmic Plast Reconstr Surg 2011; 27: 461.
- Palumbo A, Rajkumar SV, Jesus F, et al. International myeloma working group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation. J Clin Oncol 2014; 32: 587–600
Öz
Extramedullary plasmacytoma is a rare plasma cell neoplasia. It often involves the upper respiratory tract, eye involvement is extremely rare. In this report, we present a case of extramedullary plasmacytoma of orbital origin. A 55-year-old male patient, an orbitally located mass with a size of 5x6 cm was detected in the examinations performed for swelling in the left eye. In the histopathological examination of the mass, abundant plasma cells among amyloid were observed, and monoclonality with kappa-lambda was observed. The case was reported as plasma cell neoplasia and was accepted as a solitary plasmacytoma since no other focus was detected in the tests. Extramedullary plasmacytoma should be kept in mind in orbitally located masses. Since the prognosis is different, the presence of a systemic plasma cell dyscrasia should be questioned in its diagnosis.
Anahtar Kelimeler
Proje Numarası
-
Kaynakça
- Siegel R, Naishadham D, Jemal A. Cancer statistics. CA Cancer J Clin. 2012 2012; 62: 10–29
- Matos A, Goulart A, Ribeiro A, et al. Orbital plasmacytoma, an uncommon presentation of advanced multiple myeloma. Eur J Case Rep Intern Med 2020; 7: 001149.
- Wang SSY, Lee MB, George A, et al. Five cases of orbital extramedullary plasmacytoma: diagnosis and management of an aggressive malignancy. Orbit 2019; 38: 218-25.
- Bhadauria BM, Ranjan P, Mishra D. Primary orbital plasmacytoma mimicking lacrimal gland tumor. Orbit 2014; 33: 305–7
- Barmas-Alamdari D, Sodhi GS, Shenouda TA. Bilateral proptosis in a case of recurring multiple myeloma: uncommon orbital presentation of plasmacytoma. Int Med Case Rep J 2020; 13: 297-301.
- Sharma S, Kaur R, Bal A, Mohindra S, et al. Primary orbital plasmacytoma: An unusual presentation in an adolescent. Indian J Pathol Microbiol 2018; 61: 158-9.
- Vatansever M, Bozkurt FM, Dinç E, et al. Orbital metastasis of multiple myeloma: case report. Turk J Ophthalmol 2016; 46: 148-50.
- Bhadauria M, Ranjan P, Mishra D. Primary orbital plasmacytoma mimicking lacrimal gland tumor. Orbit 2014; 33: 305-7.
- Rodriguez T, Bon V. Secondary extramedullary bilateral orbital plasmacytoma in a 65-year-old man. J Fr Ophtalmol 2019; 42: 267-9.
- Hsu VJ, Agarwal MR, Chen CS, et al. IgA orbital plasmacytoma in multiple myeloma. Ophthalmic Plast Reconstr Surg 2010; 26: 126-7.
- Pierre-Filho, Paulo de Tarso P, do Carmo Carvalho F, et al. Orbital extramedullary plasmacytoma leading to exenteration. Can J Ophthalmol 2004; 39: 557.
- Ockrim ZK, Deutch J, Izon J. Bilateral retro-orbital plasmacytoma. Eye (Lond) 2000; 14: 795-7.
- Uceda-Montañés A, Blanco G, Saornil MA, et al. Extramedullary plasmacytoma of the orbit. Acta Ophthalmol Scand 2000; 78: 601-3.
- Liao J, Greenberg A, Shinder R. Relapsed multiple myeloma presenting as an orbital plasmacytoma. Ophthalmic Plast Reconstr Surg 2011; 27: 461.
- Palumbo A, Rajkumar SV, Jesus F, et al. International myeloma working group consensus statement for the management, treatment, and supportive care of patients with myeloma not eligible for standard autologous stem-cell transplantation. J Clin Oncol 2014; 32: 587–600
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Case Report [en] Olgu Sunumu [tr] |
| Yazarlar | |
| Proje Numarası | - |
| Yayımlanma Tarihi | 8 Eylül 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 2 Sayı: 3 |
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