A case of parathyroid carcinoma mimicking parathyroid adenoma

Semra Demirli Atıcı; Değercan Yeşilyurt; Dudu Solakoğlu Kahraman; Emre Dikmeer; Hakan Öğücü; Halit Batuhan Demir; Gökhan Akbulut

doi:10.28982/josam.473603

Olgu Sunumu

Paratiroid adenomunu taklit eden paratiroid karsinomu olgusu

Yıl 2019, Cilt: 3 Sayı: 3, 265 - 267, 15.03.2019

Semra Demirli Atıcı Değercan Yeşilyurt Dudu Solakoğlu Kahraman Emre Dikmeer Hakan Öğücü Halit Batuhan Demir Gökhan Akbulut

https://doi.org/10.28982/josam.473603

Öz

Paratiroid karsinomu nadir görülen endokrin tümörlerden biri olup primer hiperparatiroidizmli olgularının %1'ini oluşturmaktadır. Benzer görüntüleme yöntemleri ve benzer klinik bulgular nedeniyle preoperatif paratiroid adenomları ve paratiroid karsinomu ayırt etmek zordur. 70 yaşında kadın hasta, yorgunluk ve yaygın kemik ağrısı şikayeti ile başvurdu. Laboratuvar testleri, artmış parathormon düzeyi, boyun ultrasonografisi ve paratiroid sintigrafisi, primer hiperparatiroidizm ile uyumluydu. Paratiroid adenomunu destekleyen görüntüleme yöntemleri ile hasta paratiroid adenomuna bağlı primer hiperparatiroidi ön tanısı ile opere edildi. Ameliyat sonrası problem saptanmayan hasta, postoperatif beşinci günde sorunsuz bir şekilde taburcu edildi. Postoperatif patoloji paratiroid adenomunda gelişen paratiroid karsinomu olarak rapor edildi. Paratiroid karsinomu ve paratiroid adenomu benzer klinik ve görüntüleme yöntemlerine sahiptir, preoperatif tanı koymak zordur.

Anahtar Kelimeler

Hiperkalsemi, Primer hiperparatiroidizm, Paratiroid adenomu, Paratiroid karsinomu

Kaynakça

1. Shane E. Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab. 2001 Feb;86(2),:485-93.
2. Haven CJ, van Puijenbroek M, Tan MH, Teh BT, Fleuren GJ, van Wezel T, et al. Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroidcarcinomas. Clin Endocrinol. 2007;67:370-6.
3. Wassif WS, Moniz CF, Friedman E, Wong S, Weber G, Nordenskjöld M, Peters TJ, Larsson C. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993 Dec;77(6):1485-9.
4. Tamler R, Lewis MS, LiVolsi VA, Genden EM. Parathyroid carcinoma: ultrasonographic and histologic features. Thyroid. 2005 Jul;15(7):744-5.
5. Fernandes JMP, Paiva C, Correia R, Polónia J, Moreira da Costa A. Parathyroid carcinoma: From a case report to a review of the literature. Int J Surg Case Rep. 2018;42:214-217. doi: 10.1016/j.ijscr.2017.11.030.
6. Marcocci C, Cetani F, Rubin MR, Silverberg SJ, Pinchera A, Bilezikian JP. Parathyroidcarcinoma. J Bone MinerRes. 2008;23:1869-80.
7. Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P. Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest. 2000 Apr;23(4):255-7.
8. Chiofalo MG, Scognamiglio F, Losito S, Lastoria S, Marone U, Pezzullo L. Huge parathyroid carcinoma: clinical considerations and literature review. World J Surg Oncol. 2005 Jun 23;3:39.
9. Koea JB, Shaw JH. Parathyroid cancer: biology and management. Surg Oncol. 1999 Nov;8(3):155-65.
10. Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO. Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg. 1992 Jul-Aug;16(4):724-31.
11. Givi B, Shah JP. Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 2010 Aug;22(6):498-507.
12. Munson ND, Foote RL, Northcutt RC, Tiegs RD, Fitzpatrick LA, Grant CS, et al. Parathyroid carcinoma: is there a role for adjuvant radiation therapy? Cancer. 2003;98(11):2378–84.

A case of parathyroid carcinoma mimicking parathyroid adenoma

Yıl 2019, Cilt: 3 Sayı: 3, 265 - 267, 15.03.2019

Semra Demirli Atıcı Değercan Yeşilyurt Dudu Solakoğlu Kahraman Emre Dikmeer Hakan Öğücü Halit Batuhan Demir Gökhan Akbulut

https://doi.org/10.28982/josam.473603

Öz

Parathyroid carcinoma is one of the rare endocrine tumors and constitutes 1% of the cases with primary hyperparathyroidism. Because of similar imaging modalities and similar clinical findings, it is difficult to distinguish between preoperative parathyroid adenomas and parathyroid carcinoma. A 70-year-old female patient presented with fatigue and generalized bone pain. Her laboratory tests, neck and parathyroid scintigraphy were compatible with primary hyperparathyroidism with a significantly elevated level of parathormone. With the imaging methods which supported parathyroid adenoma, the patient was operated with a presumptive diagnosis of primary hyperparathyroidism due to parathyroid adenoma. The postoperative course was unremarkable and she was discharged on the postoperative fifth day. Postoperative pathology was reported as parathyroid carcinoma developed in a parathyroid adenoma. Parathyroid carcinoma and parathyroid adenoma have similar clinically and imaging methods, it is difficult to diagnose preoperatively.

Anahtar Kelimeler

Hypercalcemia, Primary hyperparathyroidism, Parathyroid adenoma, Parathyroid carcinoma

Kaynakça

1. Shane E. Clinical review 122: Parathyroid carcinoma. J Clin Endocrinol Metab. 2001 Feb;86(2),:485-93.
2. Haven CJ, van Puijenbroek M, Tan MH, Teh BT, Fleuren GJ, van Wezel T, et al. Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroidcarcinomas. Clin Endocrinol. 2007;67:370-6.
3. Wassif WS, Moniz CF, Friedman E, Wong S, Weber G, Nordenskjöld M, Peters TJ, Larsson C. Familial isolated hyperparathyroidism: a distinct genetic entity with an increased risk of parathyroid cancer. J Clin Endocrinol Metab. 1993 Dec;77(6):1485-9.
4. Tamler R, Lewis MS, LiVolsi VA, Genden EM. Parathyroid carcinoma: ultrasonographic and histologic features. Thyroid. 2005 Jul;15(7):744-5.
5. Fernandes JMP, Paiva C, Correia R, Polónia J, Moreira da Costa A. Parathyroid carcinoma: From a case report to a review of the literature. Int J Surg Case Rep. 2018;42:214-217. doi: 10.1016/j.ijscr.2017.11.030.
6. Marcocci C, Cetani F, Rubin MR, Silverberg SJ, Pinchera A, Bilezikian JP. Parathyroidcarcinoma. J Bone MinerRes. 2008;23:1869-80.
7. Spinelli C, Bonadio AG, Berti P, Materazzi G, Miccoli P. Cutaneous spreading of parathyroid carcinoma after fine needle aspiration cytology. J Endocrinol Invest. 2000 Apr;23(4):255-7.
8. Chiofalo MG, Scognamiglio F, Losito S, Lastoria S, Marone U, Pezzullo L. Huge parathyroid carcinoma: clinical considerations and literature review. World J Surg Oncol. 2005 Jun 23;3:39.
9. Koea JB, Shaw JH. Parathyroid cancer: biology and management. Surg Oncol. 1999 Nov;8(3):155-65.
10. Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO. Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg. 1992 Jul-Aug;16(4):724-31.
11. Givi B, Shah JP. Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 2010 Aug;22(6):498-507.
12. Munson ND, Foote RL, Northcutt RC, Tiegs RD, Fitzpatrick LA, Grant CS, et al. Parathyroid carcinoma: is there a role for adjuvant radiation therapy? Cancer. 2003;98(11):2378–84.

Toplam 12 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Cerrahi
Bölüm	Olgu sunumu
Yazarlar	Semra Demirli Atıcı 0000-0002-8287-067X Değercan Yeşilyurt Bu kişi benim 0000-0001-6938-2076 Dudu Solakoğlu Kahraman Bu kişi benim 0000-0002-4126-5326 Emre Dikmeer Bu kişi benim 0000-0001-9442-0273 Hakan Öğücü Bu kişi benim 0000-0003-4089-1162 Halit Batuhan Demir 0000-0002-2746-7941 Gökhan Akbulut
Yayımlanma Tarihi	15 Mart 2019
Yayımlandığı Sayı	Yıl 2019 Cilt: 3 Sayı: 3

Kaynak Göster

APA	Demirli Atıcı, S., Yeşilyurt, D., Solakoğlu Kahraman, D., Dikmeer, E., vd. (2019). A case of parathyroid carcinoma mimicking parathyroid adenoma. Journal of Surgery and Medicine, 3(3), 265-267. https://doi.org/10.28982/josam.473603
AMA	Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G. A case of parathyroid carcinoma mimicking parathyroid adenoma. J Surg Med. Mart 2019;3(3):265-267. doi:10.28982/josam.473603
Chicago	Demirli Atıcı, Semra, Değercan Yeşilyurt, Dudu Solakoğlu Kahraman, Emre Dikmeer, Hakan Öğücü, Halit Batuhan Demir, ve Gökhan Akbulut. “A Case of Parathyroid Carcinoma Mimicking Parathyroid Adenoma”. Journal of Surgery and Medicine 3, sy. 3 (Mart 2019): 265-67. https://doi.org/10.28982/josam.473603.
EndNote	Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G (01 Mart 2019) A case of parathyroid carcinoma mimicking parathyroid adenoma. Journal of Surgery and Medicine 3 3 265–267.
IEEE	S. Demirli Atıcı, “A case of parathyroid carcinoma mimicking parathyroid adenoma”, J Surg Med, c. 3, sy. 3, ss. 265–267, 2019, doi: 10.28982/josam.473603.
ISNAD	Demirli Atıcı, Semra vd. “A Case of Parathyroid Carcinoma Mimicking Parathyroid Adenoma”. Journal of Surgery and Medicine 3/3 (Mart 2019), 265-267. https://doi.org/10.28982/josam.473603.
JAMA	Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G. A case of parathyroid carcinoma mimicking parathyroid adenoma. J Surg Med. 2019;3:265–267.
MLA	Demirli Atıcı, Semra vd. “A Case of Parathyroid Carcinoma Mimicking Parathyroid Adenoma”. Journal of Surgery and Medicine, c. 3, sy. 3, 2019, ss. 265-7, doi:10.28982/josam.473603.
Vancouver	Demirli Atıcı S, Yeşilyurt D, Solakoğlu Kahraman D, Dikmeer E, Öğücü H, Demir HB, Akbulut G. A case of parathyroid carcinoma mimicking parathyroid adenoma. J Surg Med. 2019;3(3):265-7.

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