Araştırma Makalesi
BibTex RIS Kaynak Göster

INVESTIGATION OF PLEOMORPHIC ADENOMAS IN SALIVARY GLAND, CORRELATION BETWEEN TISSUE BIOPSY AND FINE NEEDLE ASPIRATION CYTOLOGY

Yıl 2020, Cilt: 21 Sayı: 1, 30 - 34, 16.01.2020
https://doi.org/10.18229/kocatepetip.482856

Öz

OBJECTIVE: Pleomorphic adenoma is the most com-mon tumor of the salivary gland but there are very few studies that reflect the characteristics of the tumor. Our aim is to investigate the histopathological and clinico-pathological features of this tumor and to investigate the characteristics of fine needle aspiration cytology and its compatibility with tissue biopsy.

MATERIAL AND METHODS: 85 cases with pleomorphic adenoma were evaluated. The demographic characteris-tics, clinicopathological features and operative data of the patients were recorded retrospectively. The results of fine needle aspiration biopsy (FNAB) before the ope-ration were documented and the compliance of FNAB results with tissue biopsy was evaluated.

RESULTS: The male to female ratio in our patients was 1/1.96 and the mean age was 44.45 (11-87). Most of our cases were in the 40-59 age range (41.57%). The tumor was seen in the parotid gland in the majority (59%) and in the minor salivary glands in the 2nd order (18%). The mean tumor diameter was 3.23 cm (1-9 cm) and the tu-mor diameter was most frequent (57.30%) in the range of 2-4 cm. The classical type was the most common (94.4%) histological type. Recurrence was seen in only 1 (1.40%) of benign cases. Malignant transformation in the tumor was present in 5 (5.61%) cases. The diagnosis of pleo-morphic adenoma was as high as 80.32% with preope-rative FNAB.

CONCLUSIONS: Pleomorphic adenoma is most often seen in the parotid gland and is usually located in the su-perficial lobe. It is more frequent in the 4th to 5th decade and in the female gender. Tumor diameter is more in the range of 2-4 cm. The tumor has a low rate of recurrence and malignant transformation. Preoperative FNAB has a high diagnostic accuracy and FNAB is very important for the correct treatment approach.

Kaynakça

  • Gurung U, Shrestha BL, Sinha BK, et al. Pleomorphic adenoma of salivary glands: An experience at TUTH. Nepalese Journal of ENT Head and Neck Surgery 2010; 1(1): 8-11.
  • Mendenhall WM, Mendenhall CM, Werning JW, et al. Salivary gland pleomorphic adenoma. American journal of clinical oncology 2008; 31(1): 95-9.
  • Al-Khtoum N, Qubilat AR, Al-Zaidaneen S, et al. Clinical characteristics of pleomorphic adenoma of salivary glands among Jordanian patients. J Pak Med Assoc 2013; 63(3): 358-60.
  • Gahine R, Sudarshan V, Hussain N, et al. Pleomorphic adenoma: A diagnostic pitfall in the diagnosis of salivary gland lesions on FNAC: Case reports with review of the literature. Cytojournal 2010; 7.
  • Sathyaki DC, Gayathri R, Roy MS, et al. Pleomorphic Adenoma: An Observational Study. International Journal of Scientific Study 2016; 4(9): 115-8.
  • Valstar M, de Ridder M, van den Broek EC, et al. Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence. Oral Oncology 2017; 66 :93-9.
  • Ito FA, Jorge J, Vargas PA, Lopes, MA. Histopathological findings of pleomorphic adenomas of the salivary glands. Medicina Oral Patologia Oral Y Cirugia Bucal 2009;14(2): 57-61.
  • Fonseca FP, de Vasconcelos Carvalho M, de Almeida OP, et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology 2012; 114(2): 230-9.
  • Fu H, Wang J, Wang L, Zhang Z, He Y. Pleomorphic adenoma of the salivary glands in children and adolescents. Journal of pediatric surgery 2012; 47(4): 715-9.
  • Nezhad MJ, Moghadam SA, Mokhtari S, et al. Different Histolopathologic Features of Pleomorphic Adenoma in Salivary Glands. International Journal of Oral & Maxillofacial Pathology 2013; 4(2): 07-11.
  • Satpathy Y, Spadigam AE, Dhupar A, et al. Epithelial and stromal patterns of pleomorphic adenoma of minor salivary glands: A histopathological and histochemical study. Journal of oral and maxillofacial pathology: JOMFP 2014; 18(3): 379.
  • De Silva MN, Kosgoda KMS, Tilakaratne WM, et al. A case of giant pleomorphic adenoma of the parotid gland. Oral Oncology Extra 2004; 40(3): 43-5.
  • Abu‐Ghanem Y, Mizrachi A, Popovtzer A, et al. Recurrent pleomorphic adenoma of the parotid gland: institutional experience and review of the literature. Journal of surgical oncology 2016; 114(6): 714-8.
  • Bradley PJ. Recurrent salivary gland pleomorphic adenoma: etiology, management, and results. Current Opinion in Otolaryngology & Head and Neck Surgery 2001; 9(2): 100-8.
  • Heaton CM, Chazen JL, Van Zante A, et al. Pleomorphic adenoma of the major salivary glands: diagnostic utility of FNAB and MRI. The Laryngoscope 2013; 123(12): 3056-3060.

TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU

Yıl 2020, Cilt: 21 Sayı: 1, 30 - 34, 16.01.2020
https://doi.org/10.18229/kocatepetip.482856

Öz

AMAÇ: Pleomorfik adenom, tükürük
bezinin en sık görülen tümörüdür fakat 
tümörün özelliklerini yansıtan çok az sayıda çalışma bulunmaktadır.
Amacımız bu tümörün histopatolojik ve klinikopatolojik özelliklerini incelemek
ayrıca ince iğne aspirasyon sitolojisinin özelliklerini ve doku biopsisi ile
uyumunu araştırmak.



GEREÇ VE
YÖNTEM:

Pleomorfik adenom tanısı alan 85 olgu incelendi. Olguların demografik
özellikleri, klinikopatolojik özellikleri ve operatif verileri retrospektif
olarak kaydedildi. Operasyondan önceki 
İİAB sonuçları dökümante edildi ve İİAB sonuçlarının doku biopsisi ile
uyumu değerlendirildi.



BULGULAR: Olgularımızda erkek-kadın oranı: 1/1.96 ve yaş
ortalaması 44.45 idi (11-87). Olgularımızın çoğu 40-59 yaş aralığındaydı
(%41.57). Tümör en fazla (%59) parotis bezinde, 2. sıklıkta (%18) minör tükürük
bezlerinde görüldü. Ortalama tümör çapı 3.23 cm idi (1-9 cm) ve tümör çapı en
sık (%57.30) 2-4 cm aralığındaydı. Klasik tip en fazla görülen (%94.4) histolojik
tipti. Rekürrens benign olguların sadece 1’inde (%1.40) görüldü. Tümörde
malign transformasyon olgularımızın 5’inde (% 5.61) vardı. Operasyondan önce
yapılan İİAB ile %80.32 gibi yüksek oranda PA tanısı verilmişti.



SONUÇ: Pleomorfik adenom en fazla
parotis bezinde görülür ve burada da çoğunlukla yüzeyel  lobda yerleşir. 4.-5. dekadlarda ve kadın cinsiyette
daha sıktır. Tümör çapı 2-4 cm aralığında daha fazla görülür. Tümörün düşük
oranda nüks ve  malign transformasyon
olasılığı vardır. Preoperatif İİAB’nin tanısal doğruluğu oldukça yüksektir ve
İİAB yapılması doğru tedavi yaklaşımı açısından çok önemlidir.



ANAHTAR
KELİMELER:
pleomorfik
adenom, tükürük bezi, tümör, İİAB



 



ABSTRACT



OBJECTIVE: Pleomorphic adenoma is the most
common tumor of the salivary gland but there are very few studies that reflect
the characteristics of the tumor. Our aim is to investigate the histopathological
and clinicopathological features of this tumor and to investigate the
characteristics of fine needle aspiration cytology and its compatibility with
tissue biopsy.



MATERIAL AND
METHODS:

85 cases with pleomorphic adenoma were evaluated. The demographic
characteristics, clinicopathological features and operative data of the
patients were recorded retrospectively. The results of FNAB before the
operation were documented and the compliance of FNAB results with tissue biopsy
was evaluated.



RESULTS: The male to female ratio in our patients was 1/1.96 and the mean age was
44.45 (11-87).
Most of our cases were in the 40-59 age range (41.57%). The tumor was seen in the parotid gland in the majority (59%) and in the
minor salivary glands in the 2nd order (18%). The mean tumor diameter was 3.23
cm (1-9 cm) and the tumor diameter was most frequent (57.30%) in the range of
2-4 cm.

The classical type was the most common (94.4%) histological type.
Recurrence was seen in only 1 (1.40%) of benign cases. Malignant transformation
in the tumor was present in 5 (5.61%) cases.
The diagnosis of PA was as high as 80.32%
with preoperative FNAB.



CONCLUSIONS: Pleomorphic adenoma is most
often seen in the parotid gland and is usually located in the superficial lobe.
It is more frequent in the 4th to 5th decade and in the female gender. Tumor
diameter is more in the range of 2-4 cm. The tumor has a low rate of recurrence
and malignant transformation. Preoperative FNAB has a high diagnostic accuracy
and FNAB is very important for the correct treatment approach.



KEYWORDS: Pleomorphic adenoma, salivary gland, tumor, FNAB



 

Kaynakça

  • Gurung U, Shrestha BL, Sinha BK, et al. Pleomorphic adenoma of salivary glands: An experience at TUTH. Nepalese Journal of ENT Head and Neck Surgery 2010; 1(1): 8-11.
  • Mendenhall WM, Mendenhall CM, Werning JW, et al. Salivary gland pleomorphic adenoma. American journal of clinical oncology 2008; 31(1): 95-9.
  • Al-Khtoum N, Qubilat AR, Al-Zaidaneen S, et al. Clinical characteristics of pleomorphic adenoma of salivary glands among Jordanian patients. J Pak Med Assoc 2013; 63(3): 358-60.
  • Gahine R, Sudarshan V, Hussain N, et al. Pleomorphic adenoma: A diagnostic pitfall in the diagnosis of salivary gland lesions on FNAC: Case reports with review of the literature. Cytojournal 2010; 7.
  • Sathyaki DC, Gayathri R, Roy MS, et al. Pleomorphic Adenoma: An Observational Study. International Journal of Scientific Study 2016; 4(9): 115-8.
  • Valstar M, de Ridder M, van den Broek EC, et al. Salivary gland pleomorphic adenoma in the Netherlands: A nationwide observational study of primary tumor incidence, malignant transformation, recurrence, and risk factors for recurrence. Oral Oncology 2017; 66 :93-9.
  • Ito FA, Jorge J, Vargas PA, Lopes, MA. Histopathological findings of pleomorphic adenomas of the salivary glands. Medicina Oral Patologia Oral Y Cirugia Bucal 2009;14(2): 57-61.
  • Fonseca FP, de Vasconcelos Carvalho M, de Almeida OP, et al. Clinicopathologic analysis of 493 cases of salivary gland tumors in a Southern Brazilian population. Oral surgery, oral medicine, oral pathology and oral radiology 2012; 114(2): 230-9.
  • Fu H, Wang J, Wang L, Zhang Z, He Y. Pleomorphic adenoma of the salivary glands in children and adolescents. Journal of pediatric surgery 2012; 47(4): 715-9.
  • Nezhad MJ, Moghadam SA, Mokhtari S, et al. Different Histolopathologic Features of Pleomorphic Adenoma in Salivary Glands. International Journal of Oral & Maxillofacial Pathology 2013; 4(2): 07-11.
  • Satpathy Y, Spadigam AE, Dhupar A, et al. Epithelial and stromal patterns of pleomorphic adenoma of minor salivary glands: A histopathological and histochemical study. Journal of oral and maxillofacial pathology: JOMFP 2014; 18(3): 379.
  • De Silva MN, Kosgoda KMS, Tilakaratne WM, et al. A case of giant pleomorphic adenoma of the parotid gland. Oral Oncology Extra 2004; 40(3): 43-5.
  • Abu‐Ghanem Y, Mizrachi A, Popovtzer A, et al. Recurrent pleomorphic adenoma of the parotid gland: institutional experience and review of the literature. Journal of surgical oncology 2016; 114(6): 714-8.
  • Bradley PJ. Recurrent salivary gland pleomorphic adenoma: etiology, management, and results. Current Opinion in Otolaryngology & Head and Neck Surgery 2001; 9(2): 100-8.
  • Heaton CM, Chazen JL, Van Zante A, et al. Pleomorphic adenoma of the major salivary glands: diagnostic utility of FNAB and MRI. The Laryngoscope 2013; 123(12): 3056-3060.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Klinik Tıp Bilimleri
Bölüm Makaleler-Araştırma Yazıları
Yazarlar

Figen Aslan 0000-0002-4817-1904

Ülkü Küçük 0000-0003-2916-0123

Yayımlanma Tarihi 16 Ocak 2020
Kabul Tarihi 24 Haziran 2019
Yayımlandığı Sayı Yıl 2020 Cilt: 21 Sayı: 1

Kaynak Göster

APA Aslan, F., & Küçük, Ü. (2020). TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU. Kocatepe Tıp Dergisi, 21(1), 30-34. https://doi.org/10.18229/kocatepetip.482856
AMA Aslan F, Küçük Ü. TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU. KTD. Ocak 2020;21(1):30-34. doi:10.18229/kocatepetip.482856
Chicago Aslan, Figen, ve Ülkü Küçük. “TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU”. Kocatepe Tıp Dergisi 21, sy. 1 (Ocak 2020): 30-34. https://doi.org/10.18229/kocatepetip.482856.
EndNote Aslan F, Küçük Ü (01 Ocak 2020) TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU. Kocatepe Tıp Dergisi 21 1 30–34.
IEEE F. Aslan ve Ü. Küçük, “TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU”, KTD, c. 21, sy. 1, ss. 30–34, 2020, doi: 10.18229/kocatepetip.482856.
ISNAD Aslan, Figen - Küçük, Ülkü. “TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU”. Kocatepe Tıp Dergisi 21/1 (Ocak 2020), 30-34. https://doi.org/10.18229/kocatepetip.482856.
JAMA Aslan F, Küçük Ü. TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU. KTD. 2020;21:30–34.
MLA Aslan, Figen ve Ülkü Küçük. “TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU”. Kocatepe Tıp Dergisi, c. 21, sy. 1, 2020, ss. 30-34, doi:10.18229/kocatepetip.482856.
Vancouver Aslan F, Küçük Ü. TÜKÜRÜK BEZİNDE PLEOMORFİK ADENOMLARIN İNCELENMESİ, İNCE İĞNE ASPİRASYON SİTOLOJİSİNİN DOKU BİYOPSİSİ İLE KORELASYONU. KTD. 2020;21(1):30-4.

88x31.png
Bu Dergi Creative Commons Atıf-GayriTicari-AynıLisanslaPaylaş 4.0 Uluslararası Lisansı ile lisanslanmıştır.