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Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage

Yıl 2016, Cilt: 20 Sayı: 3, 243 - 251, 14.03.2016

Şehkar Oktay Burcin Alev Leyla Koc Ozturk Sevim Tunali Sezin Demirel Ebru Emekli Alturfan Tugba Tunali-akbay Serap Akyuz Refiye Yanardag Aysen Yarat

Öz

Valproic acid (2-n-propylpentanoic acid, VPA),the most widely used antiepileptic drug, has potential adverse effects and it can disrupt the oxidant and antioxidant balance. Edaravone (3-methyl-1-phenyl-2-pyrazoline-5-one, EDA) is a potent free radical scavenger. In this study, the effect of EDA on gingiva in VPA induced toxicity was investigated. Female Sprague Dawley rats were randomly divided into four groups: control group, EDA (30 mg/kg/day) given group, VPA (0.5 g/kg/day) given group,  and VPA+EDA (in same dose and time) given group. EDA and VPA were given intraperitoneally for seven days. Total protein, lipid peroxidation (LPO), sialic acid (SA) and reduced glutathione (GSH) levels and catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), superoxide dismutase (SOD), myeloperoxidase (MPO), alkaline phosphatase (ALP), acid phosphatase (ACP), sodium potassium ATPase (Na+/K+-ATPase) and tissue factor (TF) activities were determined in gingiva homogenates. The VPA-induced increases were statistically significant for MPO (p<0.01), ACP (p<0.01), Na+/K+-ATPase (p<0.05) and TF (p<0.01) activities, but not for LPO level and ALP activities.  EDA treatment markedly blunted all such elevated anomalies. Conclusively: VPA induced oxidative- and inflammatory-gingival tissue damage, reactions that were appreciably reversed by concurrent administration of EDA.

 

Key words: Gingiva, valproic acid, edaravone,  oxidative stress, inflammation

Anahtar Kelimeler

Gingiva valproic acid edaravone oxidative stress inflammation

Yıl 2016, Cilt: 20 Sayı: 3, 243 - 251, 14.03.2016

Şehkar Oktay Burcin Alev Leyla Koc Ozturk Sevim Tunali Sezin Demirel Ebru Emekli Alturfan Tugba Tunali-akbay Serap Akyuz Refiye Yanardag Aysen Yarat

Öz

Toplam 0 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Makaleler
Yazarlar

Şehkar Oktay

Burcin Alev Bu kişi benim

Leyla Koc Ozturk Bu kişi benim

Sevim Tunali Bu kişi benim

Sezin Demirel Bu kişi benim

Ebru Emekli Alturfan

Tugba Tunali-akbay

Serap Akyuz Bu kişi benim

Refiye Yanardag

Aysen Yarat

Yayımlanma Tarihi 14 Mart 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 20 Sayı: 3

Kaynak Göster

APA Oktay, Ş., Alev, B., Koc Ozturk, L., Tunali, S., vd. (2016). Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. Marmara Pharmaceutical Journal, 20(3), 243-251. https://doi.org/10.12991/mpj.20162096267
AMA Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A. Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. mpj. Mayıs 2016;20(3):243-251. doi:10.12991/mpj.20162096267
Chicago Oktay, Şehkar, Burcin Alev, Leyla Koc Ozturk, Sevim Tunali, Sezin Demirel, Ebru Emekli Alturfan, Tugba Tunali-akbay, Serap Akyuz, Refiye Yanardag, ve Aysen Yarat. “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”. Marmara Pharmaceutical Journal 20, sy. 3 (Mayıs 2016): 243-51. https://doi.org/10.12991/mpj.20162096267.
EndNote Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A (01 Mayıs 2016) Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. Marmara Pharmaceutical Journal 20 3 243–251.
IEEE Ş. Oktay, “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”, mpj, c. 20, sy. 3, ss. 243–251, 2016, doi: 10.12991/mpj.20162096267.
ISNAD Oktay, Şehkar vd. “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”. Marmara Pharmaceutical Journal 20/3 (Mayıs 2016), 243-251. https://doi.org/10.12991/mpj.20162096267.
JAMA Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A. Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. mpj. 2016;20:243–251.
MLA Oktay, Şehkar vd. “Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage”. Marmara Pharmaceutical Journal, c. 20, sy. 3, 2016, ss. 243-51, doi:10.12991/mpj.20162096267.
Vancouver Oktay Ş, Alev B, Koc Ozturk L, Tunali S, Demirel S, Emekli Alturfan E, Tunali-akbay T, Akyuz S, Yanardag R, Yarat A. Edaravone Ameliorates Valproate-Induced Gingival Toxicity by Reducing Oxidative-Stress, Inflammation and Tissue Damage. mpj. 2016;20(3):243-51.