Research Article
Distal pankreatektomide pankreas güdüğünü kapatma yöntemlerinin postoperatif pankreatik fistül üzerine etkisi
Abstract
Amaç: Çalışmamızda, DP’de pankreas güdüğünü kapatma yöntemleri ile POPF arasındaki ilişkinin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Hastanemizde 2017-2023 yıllarında DP uygulanan hastalar, retrospektif olarak tarandı. Hastalar, ISGPF 2016 tanımlamasına göre POPF gelişen grup ve gelişmeyen grup olmak üzere iki gruba ayrıldı. Güdük kapatma yöntemleri; sütürasyon, stapler kullanımı, stapler kullanımını takiben sütürasyon olmak üzere 3 grupta incelendi. Uygulanan her yöntemin sonucunda POPF görülen ve görülmeyen gruplar karşılaştırılarak yöntemlerin her birinin POPF ile ilişkisi istatistiksel açıdan değerlendirildi.
Bulgular: Çalışmaya 27 hasta dahil edildi. Hastalardan 10’una (%37,1) pankreas tümörü, 11’ine (%40,7) pankreasa invazyon gösteren başka organ tümörü, 5’ine (%18,5) travma, 1’ine (%3,7) kist hidatik nedeniyle DP uygulanmıştı. Hastaların 16’sı (%59,3) erkek, 11’i (%40,7) kadındı. Ortanca yaş 63 (44-70) idi. POPF görülmeyen hasta sayısı 20 (%74) iken POPF görülen hasta sayısı 7 (%26) idi. POPF görülmeyen grupta pankreas güdüğünü kapatma yöntemi sütürasyon olan hasta sayısı 11 (%55), stapler kullanımı olan 8 (%40), stapler kullanımını takiben sütürasyon olan 1 (%5) idi. POPF görülen grupta pankreas güdüğünü kapatma yöntemi sütürasyon olan hasta sayısı 3 (%42,8), stapler kullanımı olan 2 (%28,6), stapler kullanımını takiben sütürasyon olan hasta sayısı 2 (%28,6) idi. Gruplar arasında istatistiksel olarak anlamlı fark saptanmadı (p:0,232).
Sonuç: Çalışmamızda pankreas güdünü kapatma yöntemleri ile POPF arasında anlamlı ilişki saptanmadı. Ancak yöntemlerin birbirinden üstün olduğunu gösteren farklı çalışmalar da literatürde mevcuttur. İlerleyen dönemde konuyla ilgili daha fazla çalışma yapılması konunun aydınlatılmasında oldukça faydalı olacaktır.
References
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- Watanabe, Y., Horiuchi, A., Yoshida, M., Yamamoto, Y., Sugishita, M., Sato, K., Yukumi, S., Doi, T., & Kawachi, K. (2007). Usefulness of linear stapling device in distal pancreatic resection. Hepatogastroenterology, 54(77), 1315–1318.
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- Ecker, B. L., McMillan, M. T., Allegrini, V., Bassi, C., Beane, J. D., Beckman, R. M., Behrman, S. W., Dickson, E. J., Callery, M. P., Christein, J. D., Drebin, J. A., Hollis, R. H., House, M. G., Jamieson, N. B., Javed, A. A., Kent, T. S., Kluger, M. D., Kowalsky, S. J., Maggino, L., Malleo, G., … Vollmer, C. M., Jr (2019). Risk Factors and Mitigation Strategies for Pancreatic Fistula After Distal Pancreatectomy: Analysis of 2026 Resections From the International, Multi-institutional Distal Pancreatectomy Study Group. Annals of surgery, 269(1), 143149. https://doi.org/10.1097/SLA.0000000000002491
- Rozich, N. S., Morris, K. T., Garwe, T., Sarwar, Z., Landmann, A., Siems, C. B., Jones, A., Butler, C. S., McGaha, P. K., Axtman, B. C., Edil, B. H., & Lees, J. S. (2019). Blame it on the injury: Trauma is a risk factor for pancreatic fistula following distal pancreatectomy compared with elective resection. The journal of trauma and acute care surgery, 87(6), 1289–1300. https://doi.org/10.1097/TA.0000000000002495
- Watanabe, N., Yamamoto, Y., Sugiura, T., Okamura, Y., Ito, T., Ashida, R., & Uesaka, K. (2020). The Impact of Stump Closure Techniques on Pancreatic Fistula Stratified by the Thickness of the Pancreas in Distal Pancreatectomy. Digestive surgery, 37(4), 340–347. https://doi.org/10.1159/000505061
- Ban, D., Shimada, K., Konishi, M., Saiura, A., Hashimoto, M., & Uesaka, K. (2012). Stapler and nonstapler closure of the pancreatic remnant after distal pancreatectomy: multicenter retrospective analysis of 388 patients. World journal of surgery, 36(8), 1866–1873. https://doi.org/10.1007/s00268-012-1595-z
- Sa Cunha, A., Carrere, N., Meunier, B., Fabre, J. M., Sauvanet, A., Pessaux, P., Ortega-Deballon, P., Fingerhut, A., Lacaine, F., & French Fédération de Recherche EN Chirurgie (FRENCH) (2015). Stump closure reinforcement with absorbable fibrin collagen sealant sponge (TachoSil) does not prevent pancreatic fistula after distal pancreatectomy: the FIABLE multicenter controlled randomized study. American journal of surgery, 210(4), 739–748. https://doi.org/10.1016/j.amjsurg.2015.04.015
- Harris, L. J., Abdollahi, H., Newhook, T., Sauter, P. K., Crawford, A. G., Chojnacki, K. A., Rosato, E. L., Kennedy, E. P., Yeo, C. J., & Berger, A. C. (2010). Optimal technical management of stump closure following distal pancreatectomy: a retrospective review of 215 cases. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 14(6), 998–1005. https://doi.org/10.1007/s11605-010-1185-z
- Futagawa, Y., Takano, Y., Furukawa, K., Kanehira, M., Onda, S., Sakamoto, T., Gocho, T., Shiba, H., & Yanaga, K. (2017). Comparison of Outcomes with Hand-sewn Versus Stapler Closure of Pancreatic Stump in Distal Pancreatectomy. Anticancer research, 37(5), 2515–2521. https://doi.org/10.21873/anticanres.11593
- Kah Heng, C. A., Salleh, I., San, T. S., Ying, F., & Su-Ming, T. (2010). Pancreatic fistula after distal pancreatectomy: incidence, risk factors and management. ANZ journal of surgery, 80(9), 619–623. https://doi.org/10.1111/j.1445-2197.2010.05337.x
- Ferrone, C. R., Warshaw, A. L., Rattner, D. W., Berger, D., Zheng, H., Rawal, B., Rodriguez, R., Thayer, S. P., & Fernandez-del Castillo, C. (2008). Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 12(10), 1691–1698. https://doi.org/10.1007/s11605-008-0636-2
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- Diener, M. K., Seiler, C. M., Rossion, I., Kleeff, J., Glanemann, M., Butturini, G., Tomazic, A., Bruns, C. J., Busch, O. R., Farkas, S., Belyaev, O., Neoptolemos, J. P., Halloran, C., Keck, T., Niedergethmann, M., Gellert, K., Witzigmann, H., Kollmar, O., Langer, P., Steger, U., … Büchler, M. W. (2011). Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet (London, England), 377(9776), 1514–1522. https://doi.org/10.1016/S0140-6736(11)60237-7
- Hiyoshi, M., Wada, T., Tsuchimochi, Y. et al. Usefulness of Drain Lipase to Predict Postoperative Pancreatic Fistula After Distal Pancreatectomy. Indian J Surg 82, 841–847 (2020). https://doi.org/10.1007/s12262-02002128-8
EFFECT OF PANCREAS STUMP CLOSING METHODS IN DISTAL PANCREATECTOMY ON POSTOPERATIVE PANCREATIC FISTULA
Abstract
Aim: Our study aimed to investigate the relationship between the pancreatic stump closure methods and POPF in DP.
Materials and Methods: Patients who underwent DP in our hospital between 2017 and 2023 were retrospectively scanned. The patients were divided into two groups, the group that developed POPF and the group that did not develop, according to the ISGPF 2016 definition. The stump closure methods used in the operation are; They were examined in 3 groups: suturing, stapler use, and stapler use followed by suturing. By comparing the groups with and without POPF as a result of each method applied, the relationship of each method with POPF was evaluated statistically.
Results: In the study, 27 patients were enrolled. Among the patients who underwent DP, 10 had a pancreatic tumor, 11 had a tumor of another organ that invaded the pancreas, 5 had a trauma, and 1 had a hydatid cyst. 16 (59.3%) of the patients were male and 11 (40.7%) were female. The median age was 63 (44-70). While the number of patients without POPF was 20 (74%), the number of patients with POPF was 7 (26%). In the group without POPF, the number of patients whose method of closing the pancreatic stump was suture was 11 (55%), 8 (40%) had the use of stapler, and 1 (5%) had the use of stapler followed by suture. In the group with POPF, the number of patients whose method of closing the pancreatic stump was suture was 3 (42.8%), 2 (28.6%) had the use of stapler, and 2 (28.6%) had suture following the use of stapler. There was no statistically significant difference between the groups (p:0.232).
Conclusion: No significant relationship was found between the pancreatic stump closure methods and POPF in our study. However, there are also different studies in the literature showing that the methods are superior to each other. Further studies on the subject in the future will be quite beneficial in shedding light on the issue.
References
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- Bassi, C., Marchegiani, G., Dervenis, C., Sarr, M., Abu Hilal, M., Adham, M., Allen, P., Andersson, R., Asbun, H. J., Besselink, M. G., Conlon, K., Del Chiaro, M., Falconi, M., Fernandez-Cruz, L., Fernandez-Del Castillo, C., Fingerhut, A., Friess, H., Gouma, D. J., Hackert, T., Izbicki, J., … International Study Group on Pancreatic Surgery (ISGPS) (2017). The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After. Surgery, 161(3), 584–591.https://doi.org/10.1016/j.surg.2016.11.014
- Miao, Y., Lu, Z., Yeo, C. J., Vollmer, C. M., Jr, Fernandez-Del Castillo, C., Ghaneh, P., Halloran, C. M., Kleeff, J., de Rooij, T., Werner, J., Falconi, M., Friess, H., Zeh, H. J., Izbicki, J. R., He, J., Laukkarinen, J., Dejong, C. H., Lillemoe, K. D., Conlon, K., Takaori, K., … International Study Group of Pancreatic Surgery (ISGPS) (2020). Management of the pancreatic transection plane after left (distal) pancreatectomy: Expert consensus guidelines by the International Study Group of Pancreatic Surgery (ISGPS). Surgery, 168(1), 72–84. https://doi.org/10.1016/j.surg.2020.02.018
- Maggino, L., Malleo, G., Salvia, R., Bassi, C., & Vollmer, C. M., Jr (2019). Defining the practice of distal pancreatectomy around the world. HPB : the official journal of the International Hepato Pancreato Biliary Association, 21(10), 1277–1287. https://doi.org/10.1016/j.hpb.2019.02.016
- Shen, J., Zhang, Y., Hu, J., Wei, R., & Wu, H. (2020). Albumin difference as a new predictor of pancreatic fistula following distal pancreatectomy: a retrospective study of 211 consecutive patients. Langenbeck's archives of surgery, 405(1), 55–62. https://doi.org/10.1007/s00423-019-01849-z
- Okano, K., Kakinoki, K., Yachida, S., Izuishi, K., Wakabayashi, H., & Suzuki, Y. (2008). A simple and safe pancreas transection using a stapling device for a distal pancreatectomy. Journal of hepato-biliary-pancreatic surgery, 15(4), 353–358. https://doi.org/10.1007/s00534-008-1328-8
- Watanabe, Y., Horiuchi, A., Yoshida, M., Yamamoto, Y., Sugishita, M., Sato, K., Yukumi, S., Doi, T., & Kawachi, K. (2007). Usefulness of linear stapling device in distal pancreatic resection. Hepatogastroenterology, 54(77), 1315–1318.
- Chong, E., Ratnayake, B., Lee, S., French, J. J., Wilson, C., Roberts, K. J., Loveday, B. P. T., Manas, D., Windsor, J., White, S., & Pandanaboyana, S. (2021). Systematic review and meta-analysis of risk factors of postoperative pancreatic fistula after distal pancreatectomy in the era of 2016 International Study Group pancreatic fistula definition. HPB : the official journal of the International Hepato Pancreato Biliary Association, 23(8), 1139–1151. https://doi.org/10.1016/j.hpb.2021.02.015
- Zhou, Y., Drake, J., Deneve, J. L., Behrman, S. W., Dickson, P. V., Shibata, D., & Glazer, E. S. (2019). Rising BMI Is Associated with Increased Rate of Clinically Relevant Pancreatic Fistula after Distal Pancreatectomy for Pancreatic Adenocarcinoma. The American surgeon, 85(12), 1376–1380.
- Ecker, B. L., McMillan, M. T., Allegrini, V., Bassi, C., Beane, J. D., Beckman, R. M., Behrman, S. W., Dickson, E. J., Callery, M. P., Christein, J. D., Drebin, J. A., Hollis, R. H., House, M. G., Jamieson, N. B., Javed, A. A., Kent, T. S., Kluger, M. D., Kowalsky, S. J., Maggino, L., Malleo, G., … Vollmer, C. M., Jr (2019). Risk Factors and Mitigation Strategies for Pancreatic Fistula After Distal Pancreatectomy: Analysis of 2026 Resections From the International, Multi-institutional Distal Pancreatectomy Study Group. Annals of surgery, 269(1), 143149. https://doi.org/10.1097/SLA.0000000000002491
- Rozich, N. S., Morris, K. T., Garwe, T., Sarwar, Z., Landmann, A., Siems, C. B., Jones, A., Butler, C. S., McGaha, P. K., Axtman, B. C., Edil, B. H., & Lees, J. S. (2019). Blame it on the injury: Trauma is a risk factor for pancreatic fistula following distal pancreatectomy compared with elective resection. The journal of trauma and acute care surgery, 87(6), 1289–1300. https://doi.org/10.1097/TA.0000000000002495
- Watanabe, N., Yamamoto, Y., Sugiura, T., Okamura, Y., Ito, T., Ashida, R., & Uesaka, K. (2020). The Impact of Stump Closure Techniques on Pancreatic Fistula Stratified by the Thickness of the Pancreas in Distal Pancreatectomy. Digestive surgery, 37(4), 340–347. https://doi.org/10.1159/000505061
- Ban, D., Shimada, K., Konishi, M., Saiura, A., Hashimoto, M., & Uesaka, K. (2012). Stapler and nonstapler closure of the pancreatic remnant after distal pancreatectomy: multicenter retrospective analysis of 388 patients. World journal of surgery, 36(8), 1866–1873. https://doi.org/10.1007/s00268-012-1595-z
- Sa Cunha, A., Carrere, N., Meunier, B., Fabre, J. M., Sauvanet, A., Pessaux, P., Ortega-Deballon, P., Fingerhut, A., Lacaine, F., & French Fédération de Recherche EN Chirurgie (FRENCH) (2015). Stump closure reinforcement with absorbable fibrin collagen sealant sponge (TachoSil) does not prevent pancreatic fistula after distal pancreatectomy: the FIABLE multicenter controlled randomized study. American journal of surgery, 210(4), 739–748. https://doi.org/10.1016/j.amjsurg.2015.04.015
- Harris, L. J., Abdollahi, H., Newhook, T., Sauter, P. K., Crawford, A. G., Chojnacki, K. A., Rosato, E. L., Kennedy, E. P., Yeo, C. J., & Berger, A. C. (2010). Optimal technical management of stump closure following distal pancreatectomy: a retrospective review of 215 cases. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 14(6), 998–1005. https://doi.org/10.1007/s11605-010-1185-z
- Futagawa, Y., Takano, Y., Furukawa, K., Kanehira, M., Onda, S., Sakamoto, T., Gocho, T., Shiba, H., & Yanaga, K. (2017). Comparison of Outcomes with Hand-sewn Versus Stapler Closure of Pancreatic Stump in Distal Pancreatectomy. Anticancer research, 37(5), 2515–2521. https://doi.org/10.21873/anticanres.11593
- Kah Heng, C. A., Salleh, I., San, T. S., Ying, F., & Su-Ming, T. (2010). Pancreatic fistula after distal pancreatectomy: incidence, risk factors and management. ANZ journal of surgery, 80(9), 619–623. https://doi.org/10.1111/j.1445-2197.2010.05337.x
- Ferrone, C. R., Warshaw, A. L., Rattner, D. W., Berger, D., Zheng, H., Rawal, B., Rodriguez, R., Thayer, S. P., & Fernandez-del Castillo, C. (2008). Pancreatic fistula rates after 462 distal pancreatectomies: staplers do not decrease fistula rates. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 12(10), 1691–1698. https://doi.org/10.1007/s11605-008-0636-2
- Klein, F., Glanemann, M., Faber, W., Gül, S., Neuhaus, P., & Bahra, M. (2012). Pancreatoenteral anastomosis or direct closure of the pancreatic remnant after a distal pancreatectomy: a single-centre experience. HPB : the official journal of the International Hepato Pancreato Biliary Association, 14(12), 798–804. https://doi.org/10.1111/j.1477-2574.2012.00538.x
- Zhang, H., Zhu, F., Shen, M., Tian, R., Shi, C. J., Wang, X., Jiang, J. X., Hu, J., Wang, M., & Qin, R. Y. (2015). Systematic review and meta-analysis comparing three techniques for pancreatic remnant closure following distal pancreatectomy. The British journal of surgery, 102(1), 4–15. https://doi.org/10.1002/bjs.9653
- Diener, M. K., Seiler, C. M., Rossion, I., Kleeff, J., Glanemann, M., Butturini, G., Tomazic, A., Bruns, C. J., Busch, O. R., Farkas, S., Belyaev, O., Neoptolemos, J. P., Halloran, C., Keck, T., Niedergethmann, M., Gellert, K., Witzigmann, H., Kollmar, O., Langer, P., Steger, U., … Büchler, M. W. (2011). Efficacy of stapler versus hand-sewn closure after distal pancreatectomy (DISPACT): a randomised, controlled multicentre trial. Lancet (London, England), 377(9776), 1514–1522. https://doi.org/10.1016/S0140-6736(11)60237-7
- Hiyoshi, M., Wada, T., Tsuchimochi, Y. et al. Usefulness of Drain Lipase to Predict Postoperative Pancreatic Fistula After Distal Pancreatectomy. Indian J Surg 82, 841–847 (2020). https://doi.org/10.1007/s12262-02002128-8
There are 22 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | General Surgery |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | September 9, 2024 |
| Submission Date | February 5, 2024 |
| Acceptance Date | April 30, 2024 |
| Published in Issue | Year 2024 |