Abstract
Fifty six years old male patient admitted to our clinic with cholangitis due to anastomosis stricture after liver transplantation. Percutaneous transhepatic cholangiography (PTK) was performed and imipenem was started. Teicoplanin was added to treatment at 10th day because of fewer and elevated WBC. Tonic clonic epileptic seizures was developed 1 day after the teicoplanin was started. Cranial CT, MRI and EEG is performed. Only chronic ischemic changes was seen in MRI. At laboratory analysis, serum sodium level was 124 mEq/L and was corrected. Levetiracetam was started. The patient was entubated because of metabolic asidosis due to repeated epileptic seizures. Because of seizures started after teikoplanin and that we could not find any etiologic factor, we thought that seizure was induced by teicoplain. The drug was stopped and seizures ended. But the patient died due to ventilator associated pneumonia. Teicoplanin induced seizure must be kept in mind in infected patients with seizures.
References
- Takechi K, Fujiwara A, Watanabe Y, Kamei C. Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice. Epilepsy Rres 2009;84(2-3):127-34.
- Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci 2008;107(4):428-33.
- Rahman MA, Ago J, Matsumoto N, Ishikawa T, Kamei C. Epileptogenic activity of methicillin-resistant Staphylococcus aureus (MRSA) antibiotics in rats. Bio and Pharm Bul 2006;29(10):2035-40.
- Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: A practical clinical definition of epilepsy. Epilepsia 2014;55(4):475-82.
- Beghi E, Carpio A, Forsgren L, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010;51(4):671-5.
- Pesola GR, Avasarala J. Bupropion seizure proportion among new-onset generalized seizures and drug related seizures presenting to an emergency department. J Emerg Med 2002;22(3):235-9.
Abstract
References
- Takechi K, Fujiwara A, Watanabe Y, Kamei C. Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice. Epilepsy Rres 2009;84(2-3):127-34.
- Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci 2008;107(4):428-33.
- Rahman MA, Ago J, Matsumoto N, Ishikawa T, Kamei C. Epileptogenic activity of methicillin-resistant Staphylococcus aureus (MRSA) antibiotics in rats. Bio and Pharm Bul 2006;29(10):2035-40.
- Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: A practical clinical definition of epilepsy. Epilepsia 2014;55(4):475-82.
- Beghi E, Carpio A, Forsgren L, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010;51(4):671-5.
- Pesola GR, Avasarala J. Bupropion seizure proportion among new-onset generalized seizures and drug related seizures presenting to an emergency department. J Emerg Med 2002;22(3):235-9.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | December 1, 2017 |
| Submission Date | January 16, 2017 |
| Published in Issue | Year 2017 |