Coronary artery calcium score is associated with red blood cell distribution width and mean platelet volume
Abstract
Aim: In this paper, it
is aimed to investigate red blood cell
distribution width (RDW), mean platelet volume (MPV) and coronary artery
calcium scores (CACS) in patients with and without coronary artery disease
(CAD) detected by coronary computed tomography angiography (CCTA).
Materials and Methods: Clinical
records of 172 patients who underwent CCTA due to the presence of angina-like
symptoms were retrospectively investigated. Clinical characteristics, risk
factors for CAD, CACS and biochemical parameters including RDW and MPV were
recorded.
Results: Mean MPV (7.95 ±1.57 fL vs.
7.12±1.26 fL, p<0.001) and RDW (15.36±1.15% vs 14.37±2.01%; p<0.001)
levels were significantly higher in patients with CAD (n=85) than in those with
normal coronary arteries (n=87). CACS is positively corralated with age
(r=0.339, p<0.001), fasting glucose (r=0.223, p=0.003), C-reactive protein
(r=0.294, p<0.001), RDW (r=0.157, p=0.04) and MPV (r=0.221, p=0.004). On
multivariate logistic regression analysis, CACS [odds ratio (OR): 1.005; 95%
confidence interval (CI): 1.002-1.008; p=0.001] and MPV [OR: 1.410; 95% CI:
1.069-1.860; p=0.015] were shown to be one of the independent predictors for
CAD detected by CCTA.
Conclusion: RDW and
MPV were increased in patients with CAD detected by CCTA. These parameters were
possitively corralated with CACS which is a well-known indicator for CAD.
Because several factors may affect these parameters further prospective studies
are needed to confirm our results.
Keywords
Red blood cell distribution width mean platelet volume coronary artery calcium score coronary artery disease coronary computed tomography angiography.
References
- Fox R. Trends in cardiovascular mortality in Europe. Circulation 1997; 96 (11): 3817-21.
- Budoff MJ, Gul KM. Expert review on coronary calcium. Vasc Health Risk Manag 2008; 4 (2): 315-24.
- Budoff MJ, Achenbach S, Blumenthal RS, et al. Assessment of Coronary Artery Disease by Cardiac Computed Tomography. Circulation 2006; 114 (6): 1761-91.
- Budoff MJ, Diamond GA, Raggi P, et al. Continuous probabilistic prediction of angiographically significant coronary artery disease using electron beam tomography. Circulation 2002; 105 (15): 1791-6.
- Nieman K, van der Lugt A, Pattymana PM, de Feyter PJ. Noninvasive visualization of atherosclerotic plaque with electron beam and multislice spiral computed tomography. J Interv Cardiol 2003; 16 (2): 123-8.
- Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease. Circulation 2008; 117 (2): 163-8.
- Nabais S, Losa N, Gaspar A, et al. Association between red blood cell distribution width and outcomes at six months in patients with acute coronary syndromes. Rev Port Cardiol 2009; 28 (9): 905-24.
- Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009; 63 (10): 1509-15.
- Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8 (1): 148-56.
- Murat SN, Duran M, Kalay N, et al. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology 2013; 64 (2): 131-6.
- Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15 (4): 827-32.
- Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: Methodological issues. Platelets 2002; 13 (5-6): 301-6.
- Papanas N, Symeonidis G, Maltezos E, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15 (8): 475-8.
- Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Pract 2005; 59 (8): 981-2.
- Karabacak M, Dogan A, Turkdogan AK, Kapci M, Duman A, Akpinar O. Mean platelet volume is increased in patients with hypertensive crises. Platelets 2014; 25 (6): 423-6.
- Erne P, Wardle J, Sanders K, Lewis SM, Maseri A. Mean platelet volume and size distribution and their sensitivity to agonist in patients with coronary artery disease and congestive heart failure. Thromb Haemostas 1988; 59 (2): 259-63.
- Ma FL, Li S, Li XL, et al. Correlation of red cell distribution width with the severity of coronary artery disease: A large Chinese cohort study from a single center. Chin Med J (Engl) 2013; 126 (6): 1053-7.
- Karaçağlar E, Bal U, Hasırcı S, ve ark. Coronary artery disease detected by coronary computed tomography angiography is associated with red cell distribution width. Turk Kardiyol Dern Ars 2016; 44 (7): 570-4.
- Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension. Exp Clin Cardiol 2010; 15 (3): 37-40.
- Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community based prospective cohort. Arch Intern Med 2009; 169 (6): 588-94.
- Zalawadiya SK, Zmily H, Farah J, Daifallah S, Ali O, Ghalİ JK. Red cell distribution width and mortality in predominantly African-American population with decompensated heart failure. J Card Fail 2011; 17 (4): 292-8.
- Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009; 133 (4): 628-32.
- Drakopoulou M, Toutouzas K, Stefanadi E, Tsiamis E, Tousoulis D, Stefanadis C. Association of inflammatory markers with angiographic severity and extent of coronary artery disease. Atherosclerosis 2009; 206 (2): 335-9.
- Karagoz YA, Şahin İ, Karagoz F, Şit D. Evaluation of relationship between uric acid and CRP, RDW, and MPV as cardiovascular risk factors in patients with hypertension. Bezmialem Science 2017; 4 (1): 16-21.
- Bulunmaz M, Demir M, Uysal BB, Erdem S, Polat H, Erguney MH. Comparison of coronary artery calcium scores with platelet volume and uric acid levels in patients who underwent coronary artery Imaging with computed tomography. İstanbul Med J 2015; 16 (1): 5-9.
- Akin F, Ayça B, Köse N, et al. Effect of atorvastatin on hematologic parameters in patients with hypercholesterolemia. Angiology 2013; 64 (8): 621-5.
- Karan A, Güray Y, Güray Ü ve ark. Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease. Turk Kardiyol Dern Ars 2013; 41 (1): 45-50.
Koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ve ortalama trombosit hacmi ile ilişkilidir
Abstract
Amaç: Bu çalışmada, koroner bilgisayarlı
tomografik anjiyografi (KBTA) ile saptanan koroner arter hastalığı (KAH) ve
koroner arter kalsiyum skorunun (KAKS) kırmızı kan hücresi dağılım genişliği
(RDW) ve ortalama trombosit hacmi (MPV) arasındaki ilişkinin değerlendirilmesi amaçlandı.
Gereç ve Yöntem: Anjina veya benzeri semptomlar nedeniyle 64 kesitli KBTA uygulanan 172
hastanın tıbbi kayıtları geriye dönük olarak incelendi. Hastaların klinik
özellikleri, risk faktörleri, KAKS’ı da içeren KBTA sonuçları, RDW, MPV
değerlerini de içeren biyokimyasal ve hematolojik parametreleri kaydedildi.
Bulgular: Çalışma popülasyonu KBTA sonuçlarına göre KAH (n=85) ve normal koroner
arter (NKA) (n=87) olmak üzere iki gruba ayrıldı. Ortalama RDW (%15,36±1,15’e
karşı %14,37±2,01; p<0,001) ve MPV (7,95 ± 1,57 fL’e karşı 7,12±1,26 fL,
p<0,001) seviyeleri KAH grubunda NKA grubuna göre anlamlı olarak yüksek
saptandı. KAKS ile yaş (r=0,339, p<0,001), açlık kan şekeri (r=0,223, p=0,003),
C-reaktif protein (r=0,294, p<0,001), RDW (r=0,157, p=0,04) ve MPV (r=0,221,
p=0,004) arasında pozitif korelasyon saptandı. Yapılan çok değişkenli lojistik
regresyon analizinde KAKS [odds oranı (OR): 1,005; %95 güven aralığı (CI): 1,002-1,008;
p=0,001] ve MPV [OR: 1,410; %95 CI: 1,069-1.860; p=0.015] KBTA ile saptanan
KAH’ın bağımsız risk faktörleri arasında saptandı.
Sonuç: RDW ve MPV KAH grubunda anlamlı olarak daha yüksek saptanmıştır. Koroner
aterosklerozun iyi bir göstergesi olan KAKS ile bu parametreler arasında
pozitif bir korelasyon gösterilmiştir. MPV ve RDW düzeylerinin çok çeşitli
faktörlerden etkilenebileceği de düşünülürse bu konuda geniş kapsamlı ileri prospektif
çalışmalara ihtiyaç duyulmaktadır.
Keywords
Koroner bilgisayarlı tomografik anjiyografi koroner arter hastalığı koroner arter kalsiyum skoru kırmızı kan hücresi dağılım genişliği ortalama trombosit hacmi.
References
- Fox R. Trends in cardiovascular mortality in Europe. Circulation 1997; 96 (11): 3817-21.
- Budoff MJ, Gul KM. Expert review on coronary calcium. Vasc Health Risk Manag 2008; 4 (2): 315-24.
- Budoff MJ, Achenbach S, Blumenthal RS, et al. Assessment of Coronary Artery Disease by Cardiac Computed Tomography. Circulation 2006; 114 (6): 1761-91.
- Budoff MJ, Diamond GA, Raggi P, et al. Continuous probabilistic prediction of angiographically significant coronary artery disease using electron beam tomography. Circulation 2002; 105 (15): 1791-6.
- Nieman K, van der Lugt A, Pattymana PM, de Feyter PJ. Noninvasive visualization of atherosclerotic plaque with electron beam and multislice spiral computed tomography. J Interv Cardiol 2003; 16 (2): 123-8.
- Tonelli M, Sacks F, Arnold M, Moye L, Davis B, Pfeffer M. Relation Between Red Blood Cell Distribution Width and Cardiovascular Event Rate in People With Coronary Disease. Circulation 2008; 117 (2): 163-8.
- Nabais S, Losa N, Gaspar A, et al. Association between red blood cell distribution width and outcomes at six months in patients with acute coronary syndromes. Rev Port Cardiol 2009; 28 (9): 905-24.
- Vizioli L, Muscari S, Muscari A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009; 63 (10): 1509-15.
- Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010; 8 (1): 148-56.
- Murat SN, Duran M, Kalay N, et al. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology 2013; 64 (2): 131-6.
- Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. J Am Coll Cardiol 1990; 15 (4): 827-32.
- Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: Methodological issues. Platelets 2002; 13 (5-6): 301-6.
- Papanas N, Symeonidis G, Maltezos E, et al. Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 2004; 15 (8): 475-8.
- Coban E, Ozdogan M, Yazicioglu G, Akcit F. The mean platelet volume in patients with obesity. Int J Clin Pract 2005; 59 (8): 981-2.
- Karabacak M, Dogan A, Turkdogan AK, Kapci M, Duman A, Akpinar O. Mean platelet volume is increased in patients with hypertensive crises. Platelets 2014; 25 (6): 423-6.
- Erne P, Wardle J, Sanders K, Lewis SM, Maseri A. Mean platelet volume and size distribution and their sensitivity to agonist in patients with coronary artery disease and congestive heart failure. Thromb Haemostas 1988; 59 (2): 259-63.
- Ma FL, Li S, Li XL, et al. Correlation of red cell distribution width with the severity of coronary artery disease: A large Chinese cohort study from a single center. Chin Med J (Engl) 2013; 126 (6): 1053-7.
- Karaçağlar E, Bal U, Hasırcı S, ve ark. Coronary artery disease detected by coronary computed tomography angiography is associated with red cell distribution width. Turk Kardiyol Dern Ars 2016; 44 (7): 570-4.
- Wen Y. High red blood cell distribution width is closely associated with risk of carotid artery atherosclerosis in patients with hypertension. Exp Clin Cardiol 2010; 15 (3): 37-40.
- Perlstein TS, Weuve J, Pfeffer MA, Beckman JA. Red blood cell distribution width and mortality risk in a community based prospective cohort. Arch Intern Med 2009; 169 (6): 588-94.
- Zalawadiya SK, Zmily H, Farah J, Daifallah S, Ali O, Ghalİ JK. Red cell distribution width and mortality in predominantly African-American population with decompensated heart failure. J Card Fail 2011; 17 (4): 292-8.
- Lippi G, Targher G, Montagnana M, Salvagno GL, Zoppini G, Guidi GC. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch Pathol Lab Med 2009; 133 (4): 628-32.
- Drakopoulou M, Toutouzas K, Stefanadi E, Tsiamis E, Tousoulis D, Stefanadis C. Association of inflammatory markers with angiographic severity and extent of coronary artery disease. Atherosclerosis 2009; 206 (2): 335-9.
- Karagoz YA, Şahin İ, Karagoz F, Şit D. Evaluation of relationship between uric acid and CRP, RDW, and MPV as cardiovascular risk factors in patients with hypertension. Bezmialem Science 2017; 4 (1): 16-21.
- Bulunmaz M, Demir M, Uysal BB, Erdem S, Polat H, Erguney MH. Comparison of coronary artery calcium scores with platelet volume and uric acid levels in patients who underwent coronary artery Imaging with computed tomography. İstanbul Med J 2015; 16 (1): 5-9.
- Akin F, Ayça B, Köse N, et al. Effect of atorvastatin on hematologic parameters in patients with hypercholesterolemia. Angiology 2013; 64 (8): 621-5.
- Karan A, Güray Y, Güray Ü ve ark. Mean platelet volume and the extent of coronary atherosclerosis in patients with stable coronary artery disease. Turk Kardiyol Dern Ars 2013; 41 (1): 45-50.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | September 20, 2019 |
| Submission Date | April 20, 2018 |
| Published in Issue | Year 2019 |