Abstract
Amaç: Alopesi areata (AA), saçlı deride skar bırakmayan kıl kaybı ile karakterize, inflamatuar bir hastalıktır. Son dönemlerde inflamatuar ve otoimmun hastalıkların patogenezinde düşük antioksidan düzeyleri ve oksidatif stresin rol oynadığını gösteren çalışmalar bulunmaktadır. Çalışmadaki amacımız, vücuttaki antioksidan durumu yansıtan serum bilirubin, albümin (Alb) ve ürik asit (ÜA) düzeylerinin alopesi areata etiyopatogenezinde rolünü değerlendirmektir.
Gereç ve Yöntem: Çalışmaya dermatoloji kliniğine başvuran 62 AA hastası ile yaş ve cinsiyet olarak benzer 61 sağlıklı kontrol grubu alındı. Her iki grupta, serum total bilirubin (Tbil), direkt bilirubin (Dbil), indirekt bilirubin (İbil), ÜA ve Alb düzeyleri ölçüldü.
Bulgular: Çalışmaya 62 alopesi areata hastası (50 erkek, 12 kadın) ve 61 kontrol hastası (48 erkek, 13 kadın) dahil edildi. İki grup arasında yaş ve cinsiyet açısından istatistiksel olarak anlamlı bir fark yoktu. Alopesi areatalı hastalarda serum Tbil, İbil, ÜA ve Alb değerleri kontrol grubuna göre daha düşüktü, fakat istatistiksel olarak anlamlı bir fark yoktu.
Sonuç: Alopesi areatalı hastalarda serum Tbil, İbil, ÜA ve Alb değerlerinin kontrol grubuna göre daha düşük olması bize vücuttaki antioksidan durumu yansıtan serum bilirubin, albümin ve ürik asit düzeylerinin alopesi areata etiyopatogenezinde rolü olabileceğini düşündürmektedir. Bununla birlikte istatistiksel olarak anlamlı düzeyde düşüklük saptanmaması nedeniyle daha geniş olgu serileri içeren çalışmalara ihtiyaç olduğuna inanmaktayız.
References
- Oğuz O. Alopecia areata. Turkderm-Archives of the Turkish Dermatology and Venerology 2014; 48 (1): 40-4.
- Heıdarloo KA, Adışen E. Oxidative stress in alopecia areata and its association with disease severity, treatment and autoimmunity. Turkiye Klinikleri J Med Sci 2015; 35 (4): 268-78.
- Kılınç F, Akbaş A, Yorulmaz A, Şener S, Neşelioğlu S, Erel Ö et al. Etiyopathogenesis and oxidative stress relationship in mild severe alopecia areata. Turk J Dermatol 2017; 11 (3): 114-8.
- Motor S, Ozturk S, Ozcan O, Gurpinar AB, Can Y, Yuksel R et al. Evaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areata. Int J Clin Exp Med 2014; 7 (4): 1089-93.
- Prie BE, Voiculescu VM, Ionescu-Bozdog OB, Petrutescu B, Iosif L, Gaman LE et al. Oxidative stress and alopecia areata. J Med Life 2015; (8): 43-6.
- Karaca Ş, Güder H. Antioxidant system in dermatology. Turkish J Dermatology 2009; 3 (2): 32-9.
- Çavdar C, Sifil A, Çamsarı T. Reactive oxygen particles and antioxidant defence. Office Journal of the Turkish Nephrology, Association 1997; 3 (4): 92-5.
- Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235 (4792): 1043–6.
- Liu Y, Li P, Lu J, Xiong W, Oger J, Tetzlaff W et al. Bilirubin possesses powerful immunomodulatory activity and suppresses experimental autoimmune encephalomyelitis. J Immunol 2008; 81 (3): 1887–97.
- Kumar AN, Aruna P, Naidu JN, Kumar R, Srivastava AK. Review of concepts and controversies of uric acid as antioxidant and pro-oxidant. Archives Medical Review Journal 2015; 24 (1): 19-40.
- Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett 2008; 582 (13): 1783–7.
- Li WC, Mo LJ, Shi X, Lin ZY, Li YY, Yang Z et al. Antioxidant status of serum bilirubin, uric acid and albumin in pemphigus vulgaris. Clin Exp Dermatol 2018; 43 (2): 158-63.
- Kavak A, Baykal C, Ozarmagan G, Akar U. HLA in alopecia areata. Int J Dermatol 2000; 39 (8): 589-92.
- Naziroglu M, Kokcam I. Antioxidants and lipid peroxidation status in the blood of patients with alopecia.Cell Biochem Funct 2000;18 (3): 169-73.
- Kılıç A, Erdoğan S, Yorulmaz A, Doğan S, Ergin M, Artüz F et al. The oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus. Turkderm - Arch Turk Dermatol Venerology 2015; 49: (1): 7-12.
- Addor FAS. Antioxidants in dermatology. An Bras Dermatol. 2017; 92 (3): 356-62.
- Fuhua P, Xuhui D, Zhiyang Z, Ying J, Yu Y, Feng T et al. Antioxidant status of bilirubin and uric acid in patients with myasthenia gravis. Neuroimmunomodulation 2012; 19 (1): 43–9.
- Chen Z, Su Z, Pang W, Huang Y, Lin J, Ding Z et al. Antioxidant status of serum bilirubin and uric acid in patients with polymyositis and dermatomyositis. Int J Neurosci 2017; 127 (7): 617–23.
- Peng F, Yang Y, Liu J, Jiang Y, Zhu C, Deng X et al. Low antioxidant status of serum uric acid, bilirubin and albumin in patients with neuromyelitis optica. Eur J Neurol 2012; 19 (2): 277–83.
- Türkmen D, Altunışık N. Serum bilirubin, uric acid and albumin antioxidant levels in patients with vitiligo. Turkiye Klinikleri J Dermatol 2018; 28 (2): 63-8.
Abstract
Aim: Alopecia areata (AA) is an inflammatory disease, characterized by hair loss with no scar on the scalp. Recently, there have been studies which show that low antioxidant levels and oxidative stress play a role in the pathogenesis of inflammatory and autoimmune diseases. The aim of this study is to assess the role of serum bilirubin, albumin (Alb) and uric acid (UA) levels, which reflect the antioxidant state in the body, on the etiopathogenesis of alopecia areata.
Materials and Methods: Sixty-two AA patients who had admitted to the dermatology clinic, and 61 control subjects with similar age and sex were included in the study. Serum total bilirubin (Tbil), direct bilirubin (Dbil), indirect bilirubin (Ibil), UA and Alb levels were measured in both groups.
Results: Sixty-two alopecia areata patients (50 male, 12 female) and 61 control patients (48 male, 13 female) were included in the study. There was no statistically significant difference between the two groups in terms of age and gender. In patients with AA, serum Tbil, Ibil, UA and Alb values were lower than the control group, but there was no statistically significant difference.
Conclusion: Serum Tbil, Ibil, UA and Alb values were lower in patients with AA compared to the
control group, suggesting that the serum bilirubin, UA and Alb levels reflecting the antioxidant status in
the body may play a role in the etiopathogenesis of AA. However, we believe that there is a need for
studies involving larger case series because there is no statistically significant decrease.
References
- Oğuz O. Alopecia areata. Turkderm-Archives of the Turkish Dermatology and Venerology 2014; 48 (1): 40-4.
- Heıdarloo KA, Adışen E. Oxidative stress in alopecia areata and its association with disease severity, treatment and autoimmunity. Turkiye Klinikleri J Med Sci 2015; 35 (4): 268-78.
- Kılınç F, Akbaş A, Yorulmaz A, Şener S, Neşelioğlu S, Erel Ö et al. Etiyopathogenesis and oxidative stress relationship in mild severe alopecia areata. Turk J Dermatol 2017; 11 (3): 114-8.
- Motor S, Ozturk S, Ozcan O, Gurpinar AB, Can Y, Yuksel R et al. Evaluation of total antioxidant status, total oxidant status and oxidative stress index in patients with alopecia areata. Int J Clin Exp Med 2014; 7 (4): 1089-93.
- Prie BE, Voiculescu VM, Ionescu-Bozdog OB, Petrutescu B, Iosif L, Gaman LE et al. Oxidative stress and alopecia areata. J Med Life 2015; (8): 43-6.
- Karaca Ş, Güder H. Antioxidant system in dermatology. Turkish J Dermatology 2009; 3 (2): 32-9.
- Çavdar C, Sifil A, Çamsarı T. Reactive oxygen particles and antioxidant defence. Office Journal of the Turkish Nephrology, Association 1997; 3 (4): 92-5.
- Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235 (4792): 1043–6.
- Liu Y, Li P, Lu J, Xiong W, Oger J, Tetzlaff W et al. Bilirubin possesses powerful immunomodulatory activity and suppresses experimental autoimmune encephalomyelitis. J Immunol 2008; 81 (3): 1887–97.
- Kumar AN, Aruna P, Naidu JN, Kumar R, Srivastava AK. Review of concepts and controversies of uric acid as antioxidant and pro-oxidant. Archives Medical Review Journal 2015; 24 (1): 19-40.
- Roche M, Rondeau P, Singh NR, Tarnus E, Bourdon E. The antioxidant properties of serum albumin. FEBS Lett 2008; 582 (13): 1783–7.
- Li WC, Mo LJ, Shi X, Lin ZY, Li YY, Yang Z et al. Antioxidant status of serum bilirubin, uric acid and albumin in pemphigus vulgaris. Clin Exp Dermatol 2018; 43 (2): 158-63.
- Kavak A, Baykal C, Ozarmagan G, Akar U. HLA in alopecia areata. Int J Dermatol 2000; 39 (8): 589-92.
- Naziroglu M, Kokcam I. Antioxidants and lipid peroxidation status in the blood of patients with alopecia.Cell Biochem Funct 2000;18 (3): 169-73.
- Kılıç A, Erdoğan S, Yorulmaz A, Doğan S, Ergin M, Artüz F et al. The oxidative stress parameters and the effect of dyslipidemia on the parameters of oxidative stress in lichen planus. Turkderm - Arch Turk Dermatol Venerology 2015; 49: (1): 7-12.
- Addor FAS. Antioxidants in dermatology. An Bras Dermatol. 2017; 92 (3): 356-62.
- Fuhua P, Xuhui D, Zhiyang Z, Ying J, Yu Y, Feng T et al. Antioxidant status of bilirubin and uric acid in patients with myasthenia gravis. Neuroimmunomodulation 2012; 19 (1): 43–9.
- Chen Z, Su Z, Pang W, Huang Y, Lin J, Ding Z et al. Antioxidant status of serum bilirubin and uric acid in patients with polymyositis and dermatomyositis. Int J Neurosci 2017; 127 (7): 617–23.
- Peng F, Yang Y, Liu J, Jiang Y, Zhu C, Deng X et al. Low antioxidant status of serum uric acid, bilirubin and albumin in patients with neuromyelitis optica. Eur J Neurol 2012; 19 (2): 277–83.
- Türkmen D, Altunışık N. Serum bilirubin, uric acid and albumin antioxidant levels in patients with vitiligo. Turkiye Klinikleri J Dermatol 2018; 28 (2): 63-8.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | March 13, 2020 |
| Submission Date | November 26, 2018 |
| Published in Issue | Year 2020 |