Ege Üniversitesi hastanesi veri tabanındaki pankreas kanserlerinin epidemiyolojik ve genel sağkalım özellikleri
Abstract
Amaç: Pankreas kanserlerinin epidemiyolojisi ve genel sağkalım (GSK) özelliklerinin araştırılmasıdır.
Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Uygulama ve Araştırma Merkezine (EÜKAM) 1992-2017 yıllarında kayıtlı Ege Üniversitesi Tıp Fakültesi (EÜTF) kanser verileri retrospektif olarak taranmıştır. CANREG özel bilgisayar programına kayıtlı veriler, WHO ve Surveillance, Epidemiology, and End Results (SEER) sistemlerinde gruplanarak analizler yapılmıştır. İstatistiksel analizlerde Ki-kare, General Linear Model (GLM), Kaplan-Meier sağ kalım analizleri kullanılmıştır.
Bulgular: Toplam 117.139 kanser olgusunun 2.507’si pankreas kanseridir. Olgularımızın 1.493’ü (%59,5) erkek, 1.014’ü (%40,5) kadın olup pankreas kanseri iki cinsiyette benzer oranlarda izlenmektedir. Pankreas başı, en sık yerleşim yeridir. Genellikle ileri evrede tanı konulan kuyruk yerleşimli tümörler, erkeklerde daha sıktır (%11,5 vs. %6,2; p=0,047). Erkeklerde en sık 60 69 yaş arasında, kadınlarda ise 70 yaş üzerinde izlenmektedir. Ekzokrin tümörler, endokrin tümörlerden anlamlı oranda fazla karşılaşılmaktadır (%95 vs. %5; p=0,002). 1992 yılından 2014 yılı sonuna kadar kaydedilen pankreas kanseri olgularında doğrusal bir artış mevcuttur ve yıllara göre olan bu artış anlamlıdır (GLM: F=10,91, p<0,001). Artış cinsiyetler arasında farklılık göstermektedir. Erkeklerde daha yüksek ve doğrusal artış olduğu saptanmıştır (GLM: F=4,988, p=0,026). Hastalık prognozu oldukça kötü olup 2-, 5- ve 10-yıllık GSK oranları sırasıyla %15,9, %8,3 ve %6,0; ortanca GSK 7 aydır. Beş yıllık GSK erkeklerde %11,3 iken; kadınlarda %15,4 olup fark anlamlı bulunmuştur (p<0,001).
Sonuç: EÜTF’de EÜKAM tarafından 1992-2017 arasında, 117.139 kanser kaydı gerçekleştirilmiş, bunların 2507’si pankreas kanseridir. Pankreas kanserinde yıllara göre doğrusal artış vardır ve uzak metastatik evrede tanı konulmaktadır. En sık görülme yaş grubu olan 60-69 yaş grubu için 5 yıllık GSK %1,4 olarak bulunmuştur. Kadınlarda GSK erkeklere göre daha iyidir.
References
- Bray, F, Ferlay J, Soerjomataram I, Siegel RL., Torre LA and Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 2018;68(6):394-424.
- Haydaroglu A, Sert F, Caner A. Epidemiological and overall survival characteristics of cancer patients in Ege University Hospital database. Ege Tıp Dergisi / Ege Journal of Medicine 2019; 58: Ek Sayı /Suppl 1-9.
- Rawla P, Sunkara T, Gaduputi V. Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors. World J Oncol 2019 Feb;10(1):10-27. doi: 10.14740/wjon1166.
- Maisonneuve P, Lowenfels AB. Risk factors for pancreatic cancer: a summary review of meta-analytical studies. Int J Epidemiol 2015;44(1):186–98.
- Bosetti C, Bertuccio P, Negri E, La Vecchia C, Zeegers MP, Boffetta P. Pancreatic cancer: overview of descriptive epidemiology. Mol Carcinog 2012 Jan;51(1):3-13. doi: 10.1002/mc.20785.
- Brune KA, Lau B, Palmisano E, et al. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst 2010;102(2):119–26.
- Sun H, Ma H, Hong G, Sun H, Wang J. Survival improvement in patients with pancreatic cancer by decade: a period analysis of the SEER database, 1981-2010. Sci Rep 2014 Oct 23;4:6747. doi: 10.1038/srep06747.
- Minicozzi P, Cassetti T, Vener C, Sant M. Analysis of incidence, mortality and survival for pancreatic and biliary tract cancers across Europe, with assessment of influence of revised European age standardisation on estimates. Cancer Epidemiol. 2018 Aug;55:52-60. doi: 10.1016/j.canep.2018.04.011
Epidemiologic and survival characteristics of pancreatic cancers in Ege University hospital database
Abstract
Aim: To determine epidemiological and overall survival (OS) characteristics of pancreatic cancer patients.
Materials and Methods: Data of Ege University Cancer Control and Research Center between 1992-2017 were screened retrospectively. Data recorded in CANREG program were grouped and analyzed in WHO and Surveillance, Epidemiology, and End Results (SEER) systems. Chi-square test, General Linear Model (GLM) and Kaplan-Meier survival analysis were used for statistical analysis.
Results: Number of pancreatic cancer cases was 2,507 among 117,139 cancer cases. 1,493 (59.5%) of our cases were male and 1,014 (40.5%) were female. Pancreatic head was the most common location. Tail located tumors were more common in males (11.5% vs. 6.2%; p =0.047). It was most common in males between the ages of 60 and 69, in females over the age of 70. Exocrine tumors were significantly higher than endocrine tumors (95% vs. 5%; p=0.002). There was a linear increase in pancreatic cancer cases recorded from 1992 to the end of 2014, and this increase over the years was significant (GLM: F=10.91, p<0.001). A higher and linear increase was found in men (GLM: F=4.988, p=0.026). Disease prognosis was poor and 2, 5 and 10 year OS rates were 15.9%, 8.3% and 6.0%, respectively; median OS was 7monhts. While 5-year OS was 11.3% in men; 15.4% of women and it was found significant (p<0.001).
Conclusion: There was a linear increase in pancreatic cancer over the years and the diagnosis was done in distant metastatic stage. The 5-year OS was 1.4% for the 60-69 years age group. OS was better in women than men.
References
- Bray, F, Ferlay J, Soerjomataram I, Siegel RL., Torre LA and Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 2018;68(6):394-424.
- Haydaroglu A, Sert F, Caner A. Epidemiological and overall survival characteristics of cancer patients in Ege University Hospital database. Ege Tıp Dergisi / Ege Journal of Medicine 2019; 58: Ek Sayı /Suppl 1-9.
- Rawla P, Sunkara T, Gaduputi V. Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors. World J Oncol 2019 Feb;10(1):10-27. doi: 10.14740/wjon1166.
- Maisonneuve P, Lowenfels AB. Risk factors for pancreatic cancer: a summary review of meta-analytical studies. Int J Epidemiol 2015;44(1):186–98.
- Bosetti C, Bertuccio P, Negri E, La Vecchia C, Zeegers MP, Boffetta P. Pancreatic cancer: overview of descriptive epidemiology. Mol Carcinog 2012 Jan;51(1):3-13. doi: 10.1002/mc.20785.
- Brune KA, Lau B, Palmisano E, et al. Importance of age of onset in pancreatic cancer kindreds. J Natl Cancer Inst 2010;102(2):119–26.
- Sun H, Ma H, Hong G, Sun H, Wang J. Survival improvement in patients with pancreatic cancer by decade: a period analysis of the SEER database, 1981-2010. Sci Rep 2014 Oct 23;4:6747. doi: 10.1038/srep06747.
- Minicozzi P, Cassetti T, Vener C, Sant M. Analysis of incidence, mortality and survival for pancreatic and biliary tract cancers across Europe, with assessment of influence of revised European age standardisation on estimates. Cancer Epidemiol. 2018 Aug;55:52-60. doi: 10.1016/j.canep.2018.04.011
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | October 26, 2020 |
| Submission Date | August 28, 2020 |
| Published in Issue | Year 2020 |