Epidemiologic and survival characteristics of patients with colorectal cancer in Ege University medical faculty database
Abstract
Aim: The aim of this study was to determine epidemiological and overall survival (OS) characteristics
of colorectal cancer (CRC) patients.
Materials and Methods: Data of Ege University Cancer Control and Research Center between 1992-
2017 were screened retrospectively. Data recorded in CANREG program were grouped and analyzed
in WHO and SEER systems. Chi-square test, General Linear Model (GLM) and Kaplan-Meier survival
analysis were used for statistical analysis.
Results: Number of CRC cases were 7285 (6.2%) among 117139 cancer cases. CRC ranked 7th
among all the cancer types. Of the CRC patients, 4330 (59%) were male. The most common
localization was rectum (38.4%). CRC increases with age. A significant increase was found at the age
of 60 years and older (p=0.022) among both genders, but the difference between genders was not
significant (p=0.299). Linear increase over the years was significant in total (GLM: F=12,349;
p<0.0001). Adenocarcinoma (86%) was the most common histologic type, 54.2% of patients were
diagnosed at locally advanced stage. The 5-year OS rate was 66.4% in locally advanced cancer and
15.8% in case of distant metastasis (p<0.0001). Median survival was 69 months, 5 and 10-year OS
rates were 53% and 40% respectively. Ten-year OS was significantly higher in women. Five and 10-
year OS rates were significantly lower in ≥70-year-old age group, and subsequently in the 20-29 years
age group if ≥70-year-old age group was not taken into account (p<0.0001).
Conclusion: There is an increase in CRC over the years, and generally the patients were diagnosed
in locally advanced stages. The 5-year OS rate was 54.5% in the 60-69 age group which accounts for
the most common age group, Ten-year OS rate was 43.3% in women which was higher than in men.
Histology and stage were the most important prognostic parameters in prognosis.
References
- Bray, F, Ferlay J, Soerjomataram I, Siegel RL., Torre LA and Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 2018;68:394-424.
- Magalhaes B, Peleteiro B, Lunet N. Dietary patterns and colorectal cancer: systematic review and meta‐ analysis. Eur J Cancer Prev. 2012;21:15‐23.
- Bates B, Cox L, Nicholson S, et al. National Diet and Nutrition Survey: Results from Years 5 and 6 (combined) of the Rolling Programme (2012/2013–2013/2014) London: Public Health England; 2016.
- Bosman, F.T. WHO Classification of Tumours of the Digestive System. World Health Organization Classification of Tumours, 4th Edition, International Agency for Research on Cancer, Lyon.
- Sağlık Bakanlığı, Kanserle Savaş Dairesi Başkanlığı, Türkiye 2010 Kanser İstatistikleri, www.kanser.gov.tr.
- Farinetti A, Zurlo V, Manenti A, Coppi F, Mattioli AV. Mediterranean diet and colorectal cancer: A systematic review. Nutrition. 2017 Nov - Dec;43-44:83-8.
- Jones P, Cade JE, Evans CEL, Hancock N, Greenwood DC. The Mediterranean diet and risk of colorectal cancer in the UK Women's Cohort Study. Int J Epidemiol. 2017 Dec 1;46(6):1786-96.
- Murphy G, Devesa SS, Cross AJ, Inskip PD, McGlynn KA, Cook MB. Sex disparities in colorectal cancer incidence by anatomic subsite, race and age. Int J Cancer. 2011;128(7): 1668-75.
- White A, Ironmonger L, Steele RJC, Ormiston-Smith N, Crawford C, Seims A. A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK. BMC Cancer. 2018;18(1):906.
- EC. The State of Men’s Health in Europe Report (Extended report) Luxembourg: European Commission; 2011.
- Wolf AM, Fontham ET, Church TR, et al. Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society. CA: A Cancer Journal for Clinicians, 2018;68:250-81.
- American Cancer Society. Cancer Facts & Figures 2019. Atlanta, Ga: American Cancer Society; 2019.
- De Angelis R, Sant M, Coleman MP, et al. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5 – a population-based study. LancetOncol 2014;15:23–34.
- Yeole BB, Sunny L, Swaminathan R, Sankaranarayanan R, Parkin DM. Population-based survival from colorectal cancer in Mumbai, (Bombay) India. Eur J Cancer. 2001Jul; 37(11):1402-8.
- Park YJ, Park KJ, Park JG, Lee KU, Choe KJ, Kim JP. Prognostic factors in 2230 Korean colorectal cancer patients: analysis of consecutively operated cases. World J Surg. 1999 Jul; 23(7):721-6.
- Arnold M, Sierra MS, Laversanne M, et al. Global patterns and trends in colorectal cancer incidence and mortality Gut 2017;66:683-91.
Ege Üniversitesi Tıp Fakültesi veri tabanındaki kolorektal kanserli olguların epidemiyolojik ve genel sağ kalım özellikleri
Abstract
Amaç: Kolorektal kanser (KRK) epidemiyolojisi ve genel sağ kalım (GSK) özelliklerinin
araştırılmasıdır.
Gereç ve Yöntem: Ege Üniversitesi Kanserle Savaş Uygulama ve Araştırma Merkezine (EÜKAM)
1992-2017 yıllarında kayıtlı Ege Üniversitesi Tıp Fakültesi kanser verileri retrospektif olarak
taranmıştır. CANREG özel bilgisayar programına kayıtlı veriler, WHO ve SEER sistemlerinde
gruplanarak analizler yapılmıştır. İstatistiksel analizlerde Ki-kare, General Linear Model (GLM),
Kaplan-Meier sağ kalım analizleri kullanılmıştır. Yerel etik kurul onayı alınmıştır.
Bulgular: Toplam 117.139 kanser olgusunun 7.285’i (%6,2) KRK’dir. KRK sıklığı, tüm olgular içinde
yedinci sırada saptanmıştır. Olguların 4.330’u (%59) erkektir. Rektum yerleşimi, %38,4 olguda
saptanmış olup, en sık lokalizasyondur. KRK yaşla artmaktadır; 60 yaş ve üzerinde her iki cinsiyette
de anlamlı artış saptanmıştır (p=0,022); cinsiyetler arası fark anlamlı değildir (p=0,299). KRK’de yıllara
göre doğrusal artış toplamda anlamlıdır (GLM: F=12,349; p<0,0001). Olguların %86’sı
adenokarsinomdur, %54,2’si lokal ileri evrede tanı almıştır. Lokal ileri evrede beş yıllık GSK %66,4
iken, uzak metastaz varlığında %15,8’e düşmektedir (p<0,0001). Medyan sağ kalım 69 ay, beş ve 10
yıllık GSK oranları sırasıyla %53 ve %40’tır. On yıllık GSK oranı kadınlarda istatistiksel olarak anlamlı
yüksektir. Yetmiş yaş ve üstü, beş ve 10 yıllık GSK oranları istatistiksel olarak anlamlı düşüktür, 20-29
yaş olgularda GSK, 70 yaş ve üstü dikkate alınmazsa anlamlı düşük bulunmuştur (p<0,0001).
Sonuç: Hastanemizde yıllara göre KRK’de artış vardır, tanı genellikle lokal ileri evrede konulmuştur.
En sık görülme yaşı olan 60-69 yaş grubunda beş yıllık GSK %54,5’dir. On yıllık GSK kadınlarda
%43,3 olup erkeklerden daha yüksektir. Prognozda histoloji ve evre en belirleyici parametrelerdir.
References
- Bray, F, Ferlay J, Soerjomataram I, Siegel RL., Torre LA and Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 2018;68:394-424.
- Magalhaes B, Peleteiro B, Lunet N. Dietary patterns and colorectal cancer: systematic review and meta‐ analysis. Eur J Cancer Prev. 2012;21:15‐23.
- Bates B, Cox L, Nicholson S, et al. National Diet and Nutrition Survey: Results from Years 5 and 6 (combined) of the Rolling Programme (2012/2013–2013/2014) London: Public Health England; 2016.
- Bosman, F.T. WHO Classification of Tumours of the Digestive System. World Health Organization Classification of Tumours, 4th Edition, International Agency for Research on Cancer, Lyon.
- Sağlık Bakanlığı, Kanserle Savaş Dairesi Başkanlığı, Türkiye 2010 Kanser İstatistikleri, www.kanser.gov.tr.
- Farinetti A, Zurlo V, Manenti A, Coppi F, Mattioli AV. Mediterranean diet and colorectal cancer: A systematic review. Nutrition. 2017 Nov - Dec;43-44:83-8.
- Jones P, Cade JE, Evans CEL, Hancock N, Greenwood DC. The Mediterranean diet and risk of colorectal cancer in the UK Women's Cohort Study. Int J Epidemiol. 2017 Dec 1;46(6):1786-96.
- Murphy G, Devesa SS, Cross AJ, Inskip PD, McGlynn KA, Cook MB. Sex disparities in colorectal cancer incidence by anatomic subsite, race and age. Int J Cancer. 2011;128(7): 1668-75.
- White A, Ironmonger L, Steele RJC, Ormiston-Smith N, Crawford C, Seims A. A review of sex-related differences in colorectal cancer incidence, screening uptake, routes to diagnosis, cancer stage and survival in the UK. BMC Cancer. 2018;18(1):906.
- EC. The State of Men’s Health in Europe Report (Extended report) Luxembourg: European Commission; 2011.
- Wolf AM, Fontham ET, Church TR, et al. Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society. CA: A Cancer Journal for Clinicians, 2018;68:250-81.
- American Cancer Society. Cancer Facts & Figures 2019. Atlanta, Ga: American Cancer Society; 2019.
- De Angelis R, Sant M, Coleman MP, et al. Cancer survival in Europe 1999–2007 by country and age: results of EUROCARE-5 – a population-based study. LancetOncol 2014;15:23–34.
- Yeole BB, Sunny L, Swaminathan R, Sankaranarayanan R, Parkin DM. Population-based survival from colorectal cancer in Mumbai, (Bombay) India. Eur J Cancer. 2001Jul; 37(11):1402-8.
- Park YJ, Park KJ, Park JG, Lee KU, Choe KJ, Kim JP. Prognostic factors in 2230 Korean colorectal cancer patients: analysis of consecutively operated cases. World J Surg. 1999 Jul; 23(7):721-6.
- Arnold M, Sierra MS, Laversanne M, et al. Global patterns and trends in colorectal cancer incidence and mortality Gut 2017;66:683-91.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Supplement |
| Authors | |
| Publication Date | December 31, 2019 |
| Submission Date | February 15, 2019 |
| Published in Issue | Year 2019Volume: 58 Suppl: 2 (Oncology) |
