Research Article
Year 2018,
Volume: 57 Issue: 3, 163 - 166, 14.09.2018
Abstract
Amaç: Ortalama trombosit hacmi (mean platelet volume-MPV), platelet büyüklüğünü ve aktivitesi gösteren bir belirteçtir. MPV’nin, proinflamatuvar ve protrombik durumları yansıttığı bilinmektedir. Bazı çalışmalarda, MPV seviyelerinin, sinovitli hastalarda inflamasyon ve eritrosit sedimentasyon hızı (ESH) ile negatif ilişkili olduğu saptanmıştır. Bu bilgiler doğrultusunda, çalışmamızda dizde osteoartrit (OA) bulunan hastalarda MPV düzeyinin, radyolojik evre, klinik durum ve inflamatuvar belirteçler ile ilişkisinin araştırılması planlanmıştır.
Gereç ve Yöntem: Çalışmamıza Ocak 2016-Mart 2016 tarihleri arasında polikliniğimize başvuran ve diz OA tanısı ile takip edilen 160 hasta dahil edildi. Hastaların MPV, ESH ve C-reaktif protein (CRP) değerleri kaydedildi. Hastaların ağrı şiddetini ölçmek için vizüel anolog skala (VAS), fonksiyonel durumlarını değerlendirmek için Western Ontario ve McMaster Üniversiteleri Osteoartrit İndeksi (WOMAC) formu kullanıldı. Anteroposterior diz radyografilerinde Kellgren-Lawrence (KL) yöntemine göre radyolojik evreleme yapıldı.
Bulgular: MPV değeri ile ESH, CRP, total WOMAC skoru ve vizüel anolog skala (VAS) arasında korelasyon saptanmazken, MPV ile platelet sayımı negatif korele idi (r=-0.374). MPV seviyeleri, KL gruplarına (KL 1-4) göre analiz edildiğinde, gruplar arasında fark gözlenmedi (p=0.090). Hastalar hafif (KL 1-2) ve orta-ileri evre (KL 3-4) OA olarak değerlendirildiğinde, gruplar arasında MPV seviyeleri açısından anlamlı fark saptanmadı (p=0.066).
Sonuç: Diz OA’lı hastalarda, MPV seviyesi; radyolojik evreden bağımsız olup, klinik durum, ESH ve CRP düzeyleri ile de ilişkili bulunmamıştır. MPV’nin osteoartrit aktivitesindeki olası rolünün değerlendirilebilmesi için daha kapsamlı çalışmalara ihtiyaç vardır.
References
- Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets 2014;25(2):81-5.
- Tezcan ME, Demir Ş, Sargın M, Aliustaoğlu M, Göker B. Sjögren's syndrome and mean platelet volume. Reumatismo 2015;67(1):33-4.
- Soydinc S, Turkbeyler IH, Pehlivan Y, et al. AM. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation 2014;37(1):100-6.
- Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdoğan A, Ozturk MA. Mean platelet volume (MPV) as an inflammatory marker in anklosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75(3):291-4.
- Yazici S, Yazici M, Erer B, Calik Y, Ozhan H, Ataoğlu S. The platelet incides in patients with rheumatoid arthritis: Mean platelet volume reflects disease activity. Platelets 2010;21(2):122-5.
- Gasparyan AY, Ayvazyan L, Mikhailidis DM, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011;17(1):47-58.
- Karabulut M. To the Editor. Pediatr Cardiol 2015;36(6):1314-5.
- Voudoukis E, Karmiris K, Koutroubakis IE. Multipotent role of platelets in inflammatory bowel diseases: A clinical approach. World J Gastroenterol 2014:20(12):3180-90.
- Vakili M, Ziaee V, Moradinejad MH, Raeeskarami SR, Kompani F, Rahamooz T. Changes of platelet indices in juvenile idiopathic arthritis in acute phase and after two months treatment. Iran J Pediatr 2016;11;26(3):e5006.
- Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96(3):776-81.
- Balta S, Demirkol S, Cakar M, Celik T. Mean platelet volume as a surrogate marker of low-grade inflammation in osteoarthritis. Platelets 2014;25(8):643-4.
- Basaran S, Guzel R, Seydaoglu G, Guler Uysal F. Validity, reliability and comparison of the WOMAC osteoarthritis index and lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis. Clin Rheumatol 2010;29(7):749-56.
- Bucland-Wright JC, Macfarlane DG, Williams SA, Ward RJ. Accuracy and precision of joint space width measurements in standart and macroradiographs of osteoarthritic knees. Ann Rheum Dis 1995;54(11):872-80.
- Özdemir O. Medikal İstatistik. 1. Baskı. İstanbul: İstanbul Medikal Yayıncılık; 2006.
- Akbal A, Gökmen F, Reşorlu H. The importance of synovitis diagnosis in osteoarthritis patients in the evaluation of mean platelet volume. Platelets 2015;26(3):277.
- Taşoğlu Ö, Şahin A, Karataş G, et al. Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity. Medicine 2017;96(6):6073.
- Gasparyan AY, Sandoo A, Kalinoglou AS, Kitas GD. Mean platelet volume in patients with rheumatoid arthritis: The effect of anti-TNF-alfa therapy. Rheumatol Int 2010;30(8):1125-29.
- Zareifar S, Farahmand Far MR, Golfeshan F, Cohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal 2014;28(3):245-8.
- Sert A, Aypar E, Odabas D. Mean platelet volume in acute rheumatic fever. Platelets 2013;24(5):378-82.
Year 2018,
Volume: 57 Issue: 3, 163 - 166, 14.09.2018
Abstract
Aim: Mean platelet volume (MPV) is a marker that indicates platelet volume and activation as well as inflammatory conditions such as osteoarthritis with synovitis, rheumatoid arthritis and ankylosing spondylitis. The aim of the present study was to investigate the relationship between MPV level and the variables of physical examination, laboratory tests, and radiographic measurements in patients with knee osteoarthritis (OA).
Material and Methods: In this cross-sectional study, 160 patients with knee OA admitted to the Physical Medicine and Rehabilitation Department between January 2013 and November 2015 were included. MPV levels, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of patients were obtained from electronic database of the hospital. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate patients’ symptoms and disability. Also, patients’ pain was scored by visual analog scale (VAS). Knee OA was graded according to the Kellgren-Lawrence (KL) classification system on plain anteroposterior knee radiographs.
Results: No correlation was found between MPV and the parameters including ESR, CRP, visual analog scale score and WOMAC score. MPV was negatively correlated with platelet count (r=-0.374). When MPV level was analyzed with regard to the KL grades, no difference was found among groups (p=0.090). When patients were divided into two groups as mild OA (KL grade 1-2) and moderate-severe OA (KL grade 3-4), there was no difference between the groups in terms of MPV level (p=0.066).
Conclusion: No association was detected between MPV level and the parameters. Further studies are needed to evaluate the role of MPV level in disease activity among patients with knee osteoarthritis.
References
- Balbaloglu O, Korkmaz M, Yolcu S, Karaaslan F, Beceren NG. Evaluation of mean platelet volume (MPV) levels in patients with synovitis associated with knee osteoarthritis. Platelets 2014;25(2):81-5.
- Tezcan ME, Demir Ş, Sargın M, Aliustaoğlu M, Göker B. Sjögren's syndrome and mean platelet volume. Reumatismo 2015;67(1):33-4.
- Soydinc S, Turkbeyler IH, Pehlivan Y, et al. AM. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation 2014;37(1):100-6.
- Kisacik B, Tufan A, Kalyoncu U, Karadag O, Akdoğan A, Ozturk MA. Mean platelet volume (MPV) as an inflammatory marker in anklosing spondylitis and rheumatoid arthritis. Joint Bone Spine 2008;75(3):291-4.
- Yazici S, Yazici M, Erer B, Calik Y, Ozhan H, Ataoğlu S. The platelet incides in patients with rheumatoid arthritis: Mean platelet volume reflects disease activity. Platelets 2010;21(2):122-5.
- Gasparyan AY, Ayvazyan L, Mikhailidis DM, Kitas GD. Mean platelet volume: A link between thrombosis and inflammation? Curr Pharm Des 2011;17(1):47-58.
- Karabulut M. To the Editor. Pediatr Cardiol 2015;36(6):1314-5.
- Voudoukis E, Karmiris K, Koutroubakis IE. Multipotent role of platelets in inflammatory bowel diseases: A clinical approach. World J Gastroenterol 2014:20(12):3180-90.
- Vakili M, Ziaee V, Moradinejad MH, Raeeskarami SR, Kompani F, Rahamooz T. Changes of platelet indices in juvenile idiopathic arthritis in acute phase and after two months treatment. Iran J Pediatr 2016;11;26(3):e5006.
- Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96(3):776-81.
- Balta S, Demirkol S, Cakar M, Celik T. Mean platelet volume as a surrogate marker of low-grade inflammation in osteoarthritis. Platelets 2014;25(8):643-4.
- Basaran S, Guzel R, Seydaoglu G, Guler Uysal F. Validity, reliability and comparison of the WOMAC osteoarthritis index and lequesne algofunctional index in Turkish patients with hip or knee osteoarthritis. Clin Rheumatol 2010;29(7):749-56.
- Bucland-Wright JC, Macfarlane DG, Williams SA, Ward RJ. Accuracy and precision of joint space width measurements in standart and macroradiographs of osteoarthritic knees. Ann Rheum Dis 1995;54(11):872-80.
- Özdemir O. Medikal İstatistik. 1. Baskı. İstanbul: İstanbul Medikal Yayıncılık; 2006.
- Akbal A, Gökmen F, Reşorlu H. The importance of synovitis diagnosis in osteoarthritis patients in the evaluation of mean platelet volume. Platelets 2015;26(3):277.
- Taşoğlu Ö, Şahin A, Karataş G, et al. Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity. Medicine 2017;96(6):6073.
- Gasparyan AY, Sandoo A, Kalinoglou AS, Kitas GD. Mean platelet volume in patients with rheumatoid arthritis: The effect of anti-TNF-alfa therapy. Rheumatol Int 2010;30(8):1125-29.
- Zareifar S, Farahmand Far MR, Golfeshan F, Cohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal 2014;28(3):245-8.
- Sert A, Aypar E, Odabas D. Mean platelet volume in acute rheumatic fever. Platelets 2013;24(5):378-82.
There are 19 citations in total.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | September 14, 2018 |
| Submission Date | July 24, 2017 |
| Published in Issue | Year 2018Volume: 57 Issue: 3 |
