Abstract
Aim: In this study, clinical features of a rare ovarian tumor, Brenner tumor was emphasized.
Materials and Methods: Patients who were operated in Ege University Faculty of Medicine, Department of
Obstetrics and Gynecology and diagnosed with Brenner tumor were included. In this retrospective research, age of
the patient, tumor size, tumor localization, indication for operation, type of operation, coincident histopathological
findings and the behavior of the tumor (benign, malignant) were recorded.
Results: Mean age of the 26 patients whom included into the study was 54. In only one patient, malignant Brenner
tumor was detected; others were benign. Except two patients, all of the diagnosis were incidental and the tumor size
equal to or less than 1 cm in these patients.
Conclusion: Generally, Brenner tumors are benign and incidental neoplasms. They are detected in small sizes
especially in patients operated for other gynecological pathologies. Malignant Brenner tumors behave as other
malignant epithelial ovarian neoplasms.
Keywords
References
- Brenner F. Das Oophoroma folliculare. Frankf Z Path 1907;1:150-71.
- Lang SM, Mills AM, Cantrell LA. Malignant Brenner tumor of the ovary: Review and case report. Gynecol Oncol Rep 2017;3(22):26-31.
- Seidman JD, Khedmati F. Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with walthard cell nest. Arch Pathol Lab Med 2008;132(11):1753-60.
- Yamamoto R, Fujita M, Kuwabara M, et al. Malignant Brenner tumors of the ovary and tumor markers: Case reports. Jpn J Clin Oncol 1999;29(6):308-13.
- Silverberg SG. Brenner tumor of the ovary. A clinicopathologic study of 60 tumors in 54 women. Cancer 1971;28(3):588-96.
- Jorgensen EO, Dockerty MB, Wilson RB, Welch JS. Clinicopathologic study of 53 cases of Brenner’s tumors of the ovary. Am J Obstet Gynecol 1970;108(1):122-7.
- Yoonessi M, Abell MR. Brenner tumors of the ovary. Obstet Gynecol 1979;54(1):90-6.
- Turgay B, Koyuncu K, TaĢkın S, Ortaç UF. Features of ovarian Brenner tumors: Experience of a single tertiary center. Turk J Obstet Gynecol 2017;14(2):133-7.
- Yue Z, Si T, Pan Z, et al. Malignant Brenner tumor of the ovary: Clinical, pathological and demographic analyses of 10 cases. Int J Clin Exp Pathol 2016;9(5):5642-6.
- Austin RM and Norris HJ. Malignant Brenner tumor and transitional cell carcinoma of the ovary: A comparison. Int J Gynecol Pathol 1987;6(1):29-39.
- Nasioudis D, Sisti G, Holcomb K, Kanninen T, Witkin SS. Malignant Brenner tumors of the ovary; a population-based analysis. Gynecol Oncol 2016;142(1):44-9.
- Dada GM, Kebat TA, Dilek GB, Benzer ES, Pak I. Brenner tumor: A 2 case report; distinct macrocystic change and extraovarian localization. Ege Tıp Dergisi 2010;49(2):135-8.
- Weinberger V, Minář L, Felsinger M, et al. Brenner tumor of the ovary - ultrasound features and clinical management of a rare ovarian tumor mimicking ovarian cancer. Ginekol Pol 2018;89(7):357-63.
Abstract
Amaç: Bu çalıĢmada nadir görülen bir over tümörü olan Brenner tümörlerinin klinik özellikleri vurgulanmaya
çalıĢılmıĢtır.
Gereç ve Yöntem: ÇalıĢmaya Ege Üniversitesi Kadın Hastalıkları ve Doğum Anabilim Dalı’nda opere edilmiĢ ve
Brenner tümörü tanısı almıĢ hastalar dahil edildi. Hastaların geriye dönük incelemelerinde, yaĢı, tümör boyutu, tümör
lokalizasyonu, operasyon endikasyonları ve yapılan operasyonun tipi, eĢlik eden histopatolojik bulgular ve tümörün
malignite durumu gibi bilgiler kaydedildi.
Bulgular: ÇalıĢmaya alınan 26 hastanın ortalama yaĢı 54’tü. Bir hastada malign Brenner tanısı konulurken diğer
hastalarda tümör benign karakterde idi. Ġki hasta dıĢında, kalan tüm olgularda tanı insidental olarak kondu ve bu
olgularda tümör boyutu 1 cm ve altındaydı.
Sonuç: Brenner tümörleri, çoğunlukla benign karakterde ve insidental olarak saptanan neoplazilerdir. Genellikle diğer
jinekolojik patolojiler nedeniyle opere edilen hastalarda, küçük boyutlarda saptanmaktadır. Malign Brenner tümörleri
ise, diğer malign epitelyal over tümörleri gibi davranmaktadır.
References
- Brenner F. Das Oophoroma folliculare. Frankf Z Path 1907;1:150-71.
- Lang SM, Mills AM, Cantrell LA. Malignant Brenner tumor of the ovary: Review and case report. Gynecol Oncol Rep 2017;3(22):26-31.
- Seidman JD, Khedmati F. Exploring the histogenesis of ovarian mucinous and transitional cell (Brenner) neoplasms and their relationship with walthard cell nest. Arch Pathol Lab Med 2008;132(11):1753-60.
- Yamamoto R, Fujita M, Kuwabara M, et al. Malignant Brenner tumors of the ovary and tumor markers: Case reports. Jpn J Clin Oncol 1999;29(6):308-13.
- Silverberg SG. Brenner tumor of the ovary. A clinicopathologic study of 60 tumors in 54 women. Cancer 1971;28(3):588-96.
- Jorgensen EO, Dockerty MB, Wilson RB, Welch JS. Clinicopathologic study of 53 cases of Brenner’s tumors of the ovary. Am J Obstet Gynecol 1970;108(1):122-7.
- Yoonessi M, Abell MR. Brenner tumors of the ovary. Obstet Gynecol 1979;54(1):90-6.
- Turgay B, Koyuncu K, TaĢkın S, Ortaç UF. Features of ovarian Brenner tumors: Experience of a single tertiary center. Turk J Obstet Gynecol 2017;14(2):133-7.
- Yue Z, Si T, Pan Z, et al. Malignant Brenner tumor of the ovary: Clinical, pathological and demographic analyses of 10 cases. Int J Clin Exp Pathol 2016;9(5):5642-6.
- Austin RM and Norris HJ. Malignant Brenner tumor and transitional cell carcinoma of the ovary: A comparison. Int J Gynecol Pathol 1987;6(1):29-39.
- Nasioudis D, Sisti G, Holcomb K, Kanninen T, Witkin SS. Malignant Brenner tumors of the ovary; a population-based analysis. Gynecol Oncol 2016;142(1):44-9.
- Dada GM, Kebat TA, Dilek GB, Benzer ES, Pak I. Brenner tumor: A 2 case report; distinct macrocystic change and extraovarian localization. Ege Tıp Dergisi 2010;49(2):135-8.
- Weinberger V, Minář L, Felsinger M, et al. Brenner tumor of the ovary - ultrasound features and clinical management of a rare ovarian tumor mimicking ovarian cancer. Ginekol Pol 2018;89(7):357-63.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | March 14, 2019 |
| Submission Date | September 8, 2018 |
| Published in Issue | Year 2019Volume: 58 Issue: 1 |
