Effect of preoperative C-reactive protein/albumin ratio on postoperative survial in gastric adenocarcinomas

Kenan İsmayilzade; Erkan Güler; Muhtar Sinan Ersin; Özgür Fırat; Berk Göktepe; Taylan Özgür Sezer

doi:10.19161/etd.1522823

TR EN

Effect of CRP/ Albumin Ratio on Gastric Adenocarcinoma Survival

Öz

Giriş ve Amaç: Son evre mide kanserlerinde sağ kalım süresi hala düşük olduğundan, ek tedavi ve prognostik faktörler araştırılmaktadır. Bu çalışmada, mide adenokarsinomlarında ameliyat öncesi ölçülen C-reaktif protein (CRP)/Albumin oranının önemi ve ameliyat sonrası sağ kalım üzerindeki etkisinin değerlendirilmesi amaçlanmıştır. Hastalar ve Yöntemler: Elektif mide adenokarsinom ameliyatı geçiren toplam 258 hasta retrospektif olarak incelendi. Hastalıksız, genel sağ kalım, takipleri sırasında yapılan son BT, MRI ve PET/BT taramalarına göre değerlendirildi. Hastaların demografik verileri, ameliyat raporları, patoloji raporları ve görüntüleme sonuçları toplandı. Ameliyat öncesi CRP ve albümin değerleri kaydedildi ve CRP/Albumin oranı hesaplandı. Dışlama kriterlerinden sonra, toplam 208 hasta çalışmaya dahil edildi. Sonuçlar: Ameliyat öncesi ölçülen CRP/Albumin oranı ile ameliyat sonrası sağ kalım süresi arasında anlamlı bir ilişki vardı. CRP/Albumin oranının ölümü belirmedeki öngörü gücü %4.7 idi. CRP/Albumin oranının ölümü öngörü gücü, sağkalımı etkileyen diğer parametrelerle birlikte %42.5'e kadar yükseldi. Sonuç: Ameliyat öncesi ölçülen yüksek CRP/Albumin oranı, küratif cerrahi geçiren gastrik adenokarsinomlu hastalarda postoperatif dönemde düşük sağkalımla ilişkiliydi. CRP yüksekliğinin tümör dokusu nedeniyle düşük tutulamayabileceği gerçeği göz önüne alındığında, ameliyat öncesi dönemde hastaların beslenme durumunun iyileşmesiyle albumin düzeyinin sabitlenmesi bu oranı yönetmenin en önemli yoludur.

Anahtar Kelimeler

Effect of preoperative C-reactive protein/albumin ratio on postoperative survial in gastric adenocarcinomas

Abstract

Background and Aim: Since the survival time is still low in end-stage gastric cancers, additional treatment and prognostic factors are being investigated. This study aimed to evaluate significance of preoperatively measured C-reactive protein (CRP)/ Albumin ratio in gastric adenocarcinomas and effect on postoperative survival. Patients and Methods: A total of 258 patients underwent elective gastric adenocarcinoma surgery were investigated retrospectively. Disease-free, overall survival were evaluated according to the last CT, MRI and PET/CT scans performed during their follow-up. Demographic data, operation reports, pathology reports and imaging results of thepatients were collected. The preoperative values of CRP and albumin were recorded and CRP/ Albumin ratio was calculated . After exclusion criteria, a total of 208 patients were included in the study. Results: There was a significant relationship between the preoperatively measured CRP/Albumin ratio and postoperative survival time. The predictive power of the CRP/Albumin ratio on the exitus was 4.7%. The predictive power of CRP/Albumin ratio on the exitus increased up to 42.5% together with the other parameters affecting survival. Conclusion: High CRP/Albumin ratio measured preoperatively was associated with the low survival in the postoperative period in the patients with gastric adenocarcinomas who underwent curative surgery. Considering the fact that elevation of CRP may not be kept down due to the tumoral tissue, fixing albumin level by the healing of nutritional status of the patients in the preoperative period is the most important way to manage this rate.

Keywords

References

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Details

Primary Language

English

Subjects

Oncologic Surgery , General Surgery

Journal Section

Research Article

Authors

Kenan İsmayilzade
0000-0003-1863-0011
Türkiye

Erkan Güler ^*
0000-0003-0881-1003
Türkiye

Muhtar Sinan Ersin
0000-0003-4263-1727
Türkiye

Özgür Fırat
0000-0002-9683-8945
Türkiye

Berk Göktepe
0000-0002-0863-3297
Türkiye

Taylan Özgür Sezer
0000-0001-9030-6561
Türkiye

Publication Date

December 9, 2024

Submission Date

July 26, 2024

Acceptance Date

July 30, 2024

Published in Issue

Year 2024 Volume: 63 Number: 4

DOI

https://doi.org/10.19161/etd.1522823

IZ

https://izlik.org/JA35UE37LL

Cite

RIS / Bibtex

Vancouver

1.Kenan İsmayilzade, Erkan Güler, Muhtar Sinan Ersin, Özgür Fırat, Berk Göktepe, Taylan Özgür Sezer. Effect of preoperative C-reactive protein/albumin ratio on postoperative survial in gastric adenocarcinomas. EJM. 2024 Dec. 1;63(4):536-42. doi:10.19161/etd.1522823