Öz
Aim: To evaluate cornea and corneal biomechanical properties of patients with Fuchs heterochromic iridocylitis.
Materials and Methods: Fourteen FHI positive eyes (Group 1) and the contralateral healthy eyes (Group 2) were included. All patients underwent a detailed ophthalmic examination was performed. Also, Ocular Response Analyzer was used to detect corneal biomechanical properties, and specular microscopic evaluation for corneal endothelial cells count was performed.
Results: The mean best corrected visual acuity and intraocular pressure were statistically similar. (p values were 0.077 and 0.557, respectively). Corneal biomechanical properties including corneal hysteresis, corneal resistance factor, IOPcc and IOPg were not statistically significant. (p values were 0.521, 0.817, 0.980 and 0.980, respectively).
Mean central corneal thickness in Group 1 and 2 were 555.57±42.95 (467-626), 556.5±37.04 (480-623) micrometer, respectively. The difference was not statistically significant (p=0.959). Mean corneal endothelial cell density of Group 1 and Group 2 were 2313±420.22 (1271-2717) and 2404.42±326.75 (1566-2834) cells/mm2, respectively. The difference was not statistically significant (p=0.626).
Conclusion: Conflicting with the literature, no differences were detected in corneal biomechanical properties, central corneal thickness and corneal endothelial cell density in Fuchs Heterochromic Iridocyclitis positive eyes. However, more studies with increasing number of patients are still needed.
Kaynakça
- Monteiro LG, Orefice F. Fuchs heterochromic cyclitis. Rio de Janeiro: Cultura Médica; 2000: 796-806.
- Nalcacioglu P, Cakar Ozdal P, Simsek M. Clinical Characteristics of Fuchs' Uveitis Syndrome. Turk J Ophthalmol 2016; 46: 52-7.
- Yang P, Fang W, Jin H, Li B, Chen X, Kijlstra A. Clinical features of Chinese patients with Fuchs' syndrome. Ophthalmology 2006; 113: 473-80.
- Jones NP. Fuchs' Heterochromic Uveitis: a reappraisal of the clinical spectrum. Eye 1991; 5: 649-661.
- ElMallah MK, Asrani SG. New ways to measure intraocular pressure. Current opinion in ophthalmology 2008; 19: 122-6.
- Kotecha A. What biomechanical properties of the cornea are relevant for the clinician? Survey of ophthalmology 2007; 52: 109-14.
- Shah S, Laiquzzaman M, Bhojwani R, Mantry S, Cunliffe I. Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci 2007; 48: 3026-31.
- Gobeka H, Barut Selver Ö, Palamar Onay M, Egrilmez S, Yagci A. Corneal Biomechanical Properties Of Keratoconic Eyes Following Penetrating Keratoplasty. Turk J Ophthalmol 2018; 48: 171-7.
- Kara N, Baz Ö, Bozkurt E, Yazici AT, Demirok A, Yilmaz ÖF. Evaluation of Corneal Biomechanical Properties Measured By Ocular Response Analyzer in Eyes with Pterygium. Turk J Ophthalmol 2011;41:94-7.
- Lau W, Pye D. A clinical description of Ocular Response Analyzer measurements. Invest Ophthalmol Vis Sci 2011; 52: 2911-6.
- Küçümen RB, Sahan B, Yildirim CA, Çiftçi F. Evaluation of Corneal Biomechanical Changes After Collagen Crosslinking in Patients with Progressive Keratoconus by Ocular Response Analyzer. Turk J Ophthalmol 2018; 48: 160-5.
- Kanavi MR, Soheilian M, Yazdani S, Peyman GA. Confocal scan features of keratic precipitates in Fuchs heterochromic iridocyclitis. Cornea 2010; 29: 39-42.
- Mocan MC, Kadayifcilar S, Irkec M. In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs' uveitis syndrome. Eye 2012; 26: 119-25.
- Alanko HI, Vuorre I, Saari KM. Characteristics of corneal endothelial cells in Fuchs' heterochromic cyclitis. Acta Ophthalmol 1986; 64: 623-31.
- Szepessy Z, Toth G, Barsi A, Kranitz K, Nagy ZZ. Anterior Segment Characteristics of Fuchs Uveitis Syndrome. Ocul Immunol Inflamm 2016; 24: 594-8.
- Sen E, Ozdal P, Balikoglu-Yilmaz M et al. Are There Any Changes in Corneal Biomechanics and Central Corneal Thickness in Fuchs' Uveitis? Ocul Immunol Inflamm 2016; 24: 561-7.
- Özdal PÇ, Yazıcı A, Elgin U, Öztürk F. Central corneal thickness in Fuchs’ uveitis syndrome. Turk J Ophthalmol 2013; 43: 225-8.
- Shah S, Laiquzzaman M, Mantry S, Cunliffe I. Ocular response analyser to assess hysteresis and corneal resistance factor in low tension, open angle glaucoma and ocular hypertension. Clinical & Experimental Ophthalmology 2008; 36: 508-13.
- Tugal-Tutkun I, Guney-Tefekli E, Kamaci-Duman F, Corum I. A cross-sectional and longitudinal study of Fuchs uveitis syndrome in Turkish patients. Am J Ophthalmol 2009; 148: 510-5.
- Esfandiari H, Loewen NA, Hassanpour K, Fatourechi A, Yazdani S, Wang C. Fuchs heterochromic iridocyclitis-associated glaucoma: a retrospective comparison of primary Ahmed glaucoma valve implantation and trabeculectomy with mitomycin C. F1000Research 2018; 7: 876.
- Cankaya C, Kalayci BN. Corneal Biomechanical Characteristics in Patients with Behcet Disease. Semin Ophthalmol 2016; 31: 439-45.
- Turan-Vural E, Torun Acar B, Sevim MS, Buttanri IB, Acar S. Corneal biomechanical properties in patients with recurrent anterior uveitis. Ocul Immunol Inflamm 2012; 20: 349-53.
Öz
Amaç: Bu çalışmanın amacı Fuchs heterokromik iridosiklit (FHİ) tanılı gözler ile sağlıklı diğer gözlerin kornealarının ve kornea biyomekanik özelliklerinin karşılaştırılmasıdır.
Gereç ve Yöntem: Fuchs heterokromik iridosiklit tanılı 14 göz (Grup 1) ve sağlıklı diğer gözler (Grup 2) çalışmaya dâhil edildi. Tüm hastalara detaylı bir oftalmolojik bakıyı takiben Ocular Response Analyzer korneal biyomekanik özellikler ve speküler mikroskobi ile santral korneal kalınlık (SKK), korneal endotelyal hücre dansitesi (KEHD) değerlendirildi.
Bulgular: En iyi düzeltilmiş görme keskinliği ve intraoküler basınç istatistiksel olarak benzerdi (p değerleri sırasıyla 0,077 ve 0,557). Korneal biyomekanik parametreleri olan korneal histerezis, korneal resiztans faktör, IOPcc ve IOPg değerleri her iki grupta istatistiksel olarak benzerdi (p değerleri sırasıyla; 0,521, 0,817, 0,980 ve 0,980 idi). Ortalama santral korneal kalınlık Grup 1’de 555,57±42,95 (467-626) mikron ve Grup 2’de 556,5±37,04 (480-623) mikron olarak saptandı (p=0,959). Ortalama korneal endotel hücre dansitesi Grup 1’de 2313±420,22 (1271-2717) ve Grup 2’de 2404,42±326,75 (1566-2834) hücre/mm2 saptandı (p=0,626).
Sonuç: Sağlıklı gözler ile Fuchs Heterokromik İridosiklit tanılı gözler karşılaştırıldığında kornea biyomekanik parametreleri ve korneal endotel hücre dansitesi arasında anlamlı fark saptanmamıştır. Bu sonuçlar literatürdeki birçok çalışma ile çelişmekte olup daha geniş vaka serileri ile yeni çalışmalara ihtiyaç vardır.
Kaynakça
- Monteiro LG, Orefice F. Fuchs heterochromic cyclitis. Rio de Janeiro: Cultura Médica; 2000: 796-806.
- Nalcacioglu P, Cakar Ozdal P, Simsek M. Clinical Characteristics of Fuchs' Uveitis Syndrome. Turk J Ophthalmol 2016; 46: 52-7.
- Yang P, Fang W, Jin H, Li B, Chen X, Kijlstra A. Clinical features of Chinese patients with Fuchs' syndrome. Ophthalmology 2006; 113: 473-80.
- Jones NP. Fuchs' Heterochromic Uveitis: a reappraisal of the clinical spectrum. Eye 1991; 5: 649-661.
- ElMallah MK, Asrani SG. New ways to measure intraocular pressure. Current opinion in ophthalmology 2008; 19: 122-6.
- Kotecha A. What biomechanical properties of the cornea are relevant for the clinician? Survey of ophthalmology 2007; 52: 109-14.
- Shah S, Laiquzzaman M, Bhojwani R, Mantry S, Cunliffe I. Assessment of the biomechanical properties of the cornea with the ocular response analyzer in normal and keratoconic eyes. Invest Ophthalmol Vis Sci 2007; 48: 3026-31.
- Gobeka H, Barut Selver Ö, Palamar Onay M, Egrilmez S, Yagci A. Corneal Biomechanical Properties Of Keratoconic Eyes Following Penetrating Keratoplasty. Turk J Ophthalmol 2018; 48: 171-7.
- Kara N, Baz Ö, Bozkurt E, Yazici AT, Demirok A, Yilmaz ÖF. Evaluation of Corneal Biomechanical Properties Measured By Ocular Response Analyzer in Eyes with Pterygium. Turk J Ophthalmol 2011;41:94-7.
- Lau W, Pye D. A clinical description of Ocular Response Analyzer measurements. Invest Ophthalmol Vis Sci 2011; 52: 2911-6.
- Küçümen RB, Sahan B, Yildirim CA, Çiftçi F. Evaluation of Corneal Biomechanical Changes After Collagen Crosslinking in Patients with Progressive Keratoconus by Ocular Response Analyzer. Turk J Ophthalmol 2018; 48: 160-5.
- Kanavi MR, Soheilian M, Yazdani S, Peyman GA. Confocal scan features of keratic precipitates in Fuchs heterochromic iridocyclitis. Cornea 2010; 29: 39-42.
- Mocan MC, Kadayifcilar S, Irkec M. In vivo confocal microscopic evaluation of keratic precipitates and endothelial morphology in Fuchs' uveitis syndrome. Eye 2012; 26: 119-25.
- Alanko HI, Vuorre I, Saari KM. Characteristics of corneal endothelial cells in Fuchs' heterochromic cyclitis. Acta Ophthalmol 1986; 64: 623-31.
- Szepessy Z, Toth G, Barsi A, Kranitz K, Nagy ZZ. Anterior Segment Characteristics of Fuchs Uveitis Syndrome. Ocul Immunol Inflamm 2016; 24: 594-8.
- Sen E, Ozdal P, Balikoglu-Yilmaz M et al. Are There Any Changes in Corneal Biomechanics and Central Corneal Thickness in Fuchs' Uveitis? Ocul Immunol Inflamm 2016; 24: 561-7.
- Özdal PÇ, Yazıcı A, Elgin U, Öztürk F. Central corneal thickness in Fuchs’ uveitis syndrome. Turk J Ophthalmol 2013; 43: 225-8.
- Shah S, Laiquzzaman M, Mantry S, Cunliffe I. Ocular response analyser to assess hysteresis and corneal resistance factor in low tension, open angle glaucoma and ocular hypertension. Clinical & Experimental Ophthalmology 2008; 36: 508-13.
- Tugal-Tutkun I, Guney-Tefekli E, Kamaci-Duman F, Corum I. A cross-sectional and longitudinal study of Fuchs uveitis syndrome in Turkish patients. Am J Ophthalmol 2009; 148: 510-5.
- Esfandiari H, Loewen NA, Hassanpour K, Fatourechi A, Yazdani S, Wang C. Fuchs heterochromic iridocyclitis-associated glaucoma: a retrospective comparison of primary Ahmed glaucoma valve implantation and trabeculectomy with mitomycin C. F1000Research 2018; 7: 876.
- Cankaya C, Kalayci BN. Corneal Biomechanical Characteristics in Patients with Behcet Disease. Semin Ophthalmol 2016; 31: 439-45.
- Turan-Vural E, Torun Acar B, Sevim MS, Buttanri IB, Acar S. Corneal biomechanical properties in patients with recurrent anterior uveitis. Ocul Immunol Inflamm 2012; 20: 349-53.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 13 Haziran 2022 |
| Gönderilme Tarihi | 19 Eylül 2021 |
| Yayımlandığı Sayı | Yıl 2022 |