Öz
Nöroendokrin tümörler, sıklıkla gastrointestinal
sistem, akciğer ve pankreas gibi organlarda görülmektedir. Primer testiküler
nöroendokrin tümörler son derece nadir olup, tüm testis tümörlerinin %0.23’ünü
oluşturur. 35 yaşındaki hasta, sol skrotumda ağrısız şişlik şikayeti ile
üroloji kliniğine başvurdu. Hastada travma hikayesi bulunmamaktaydı. Skrotal
Doppler ultrasonograsinde sol testis alt polde 2x1.5 cm boyutlarında düzgün
sınırlı solid kitle izlendi. Tümör markerları ve bilgisayar tomografi taramaları
normaldi ve hastada metastaz izlenmedi. Hastaya sol radikal orşiektomi
uygulandı. Orşiektomi materyali, makroskobik olarak 1.4x1.2 cm boyutlarda
düzgün sınırlı, sarı solid kitle olarak izlendi. Histopatolojik incelemede
primer testiküler karsinoid tümör, iyi diferansiye nöroendokrin karsinomdan
ayırt edilemedi. Primer testiküler karsinoid tümör tanısı, klinik ve radyolojik
olarak ekstratestiküler nöroendokrin tümör dışlanarak yapıldı. Bu nadir olgu,
morfolojik ve immunhistokimyasal özellikleri ile sunulmuştur.
Anahtar Kelimeler
Kaynakça
- Langhans T. Ueber einen drusenpolyp im ileum. Virchows Arch 1867;38:559-60.
- Simon HB, McDonald JR, Culp OS. Argentaffin tumor (carcinoid) occurring in a benign cystic teratoma of the testicle. J Urol 1954;72(5):892-4.
- Lubana SS, Singh N, Chan HC, Heimann D. Primary neuroendocrine tumor (carcinoid tumor) of the testis: A case report with review of literature. Am J Case Rep 2015;31(16):328-32.
- Abbosh PH, Zhang S, Maclennan GT, et al. Germ cell origin of testicular carcinoid tumors. Clin Cancer Res 2008;14(5):1393-6.
- Mai K, Park P, Yazdi H, Carlier M. Leydig cell origin of testicular carcinoid tumor: immunohistochemical and electron microscopic evidence. Histopathology 2006;49(5):548-9.
- Davidoff MS, Schulze W, Middendorff R, Holstein AF. The Leydig cell of the human testis--a new member of the diffuse neuroendocrine system. Cell Tissue Res 1993;271(3):429-39.
- Rindi G, Klöppel G, Alhman H, et al. TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Arch 2006;449(4):395-401.
- Bosman FT CF, Hruban RH, Theise ND. World Health Organization (WHO) Classification of Tumours of the Digestive System. 4th ed. Geneva; WHO Press; 2010:102-107.
- Wang WP, Guo C, Berney DM, et al. Primary carcinoid tumors of the testis: A clinicopathologic study of 29 cases. Am J Surg Pathol 2010;34(4):519-24.
- Neely D, Gray S: Primary carcinoid tumour of the testis. Ulster Med J 2011;80(2):79-81.
Öz
Neuroendocrine tumors most commonly occur in the
gastrointestinal tract, lungs and pancreas. Primary testicular neuroendocrine
tumors are rare, constituting 0.23% of all testicular tumors. A 35-year-old man
presented to urology department with a painless left scrotal mass. He had no
history of trauma. Scrotal Doppler ultrasonography
revealed a 2×1.5 cm, well-circumscribed, solid lesion. Tumor marker levels were
normal and staging computed tomography demonstrated no evidence of metastasis.
The patient subsequently underwent left radical orchiectomy. The orchiectomy
material, grossly showed a 1.4x1.2 cm, well-circumscribed, yellow, solid mass.
On histopathologic examination, primary testicular carcinoid tumors cannot be
distinguished from well-differentiated neuroendocrine carcinoma. The diagnosis
of a primary testicular carcinoid tumor was made after ruling out an
extratesticular neuroendocrine tumor using clinical and radiological data. This
rare case is presented with clinical, morphological and immunohistochemical
features.
Anahtar Kelimeler
Kaynakça
- Langhans T. Ueber einen drusenpolyp im ileum. Virchows Arch 1867;38:559-60.
- Simon HB, McDonald JR, Culp OS. Argentaffin tumor (carcinoid) occurring in a benign cystic teratoma of the testicle. J Urol 1954;72(5):892-4.
- Lubana SS, Singh N, Chan HC, Heimann D. Primary neuroendocrine tumor (carcinoid tumor) of the testis: A case report with review of literature. Am J Case Rep 2015;31(16):328-32.
- Abbosh PH, Zhang S, Maclennan GT, et al. Germ cell origin of testicular carcinoid tumors. Clin Cancer Res 2008;14(5):1393-6.
- Mai K, Park P, Yazdi H, Carlier M. Leydig cell origin of testicular carcinoid tumor: immunohistochemical and electron microscopic evidence. Histopathology 2006;49(5):548-9.
- Davidoff MS, Schulze W, Middendorff R, Holstein AF. The Leydig cell of the human testis--a new member of the diffuse neuroendocrine system. Cell Tissue Res 1993;271(3):429-39.
- Rindi G, Klöppel G, Alhman H, et al. TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Arch 2006;449(4):395-401.
- Bosman FT CF, Hruban RH, Theise ND. World Health Organization (WHO) Classification of Tumours of the Digestive System. 4th ed. Geneva; WHO Press; 2010:102-107.
- Wang WP, Guo C, Berney DM, et al. Primary carcinoid tumors of the testis: A clinicopathologic study of 29 cases. Am J Surg Pathol 2010;34(4):519-24.
- Neely D, Gray S: Primary carcinoid tumour of the testis. Ulster Med J 2011;80(2):79-81.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Olgu Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 14 Eylül 2018 |
| Gönderilme Tarihi | 2 Ekim 2017 |
| Yayımlandığı Sayı | Yıl 2018 |