Prognostic factors and 10 years survival analysis that operated early stage non-small cell lung carcinoma
Öz
Aim: Lung cancer is at the beginning causes of deaths from cancer in the world. Despite recent advances in diagnostic methods, advanced surgical techniques, and non-surgical methods of treatment, overall 5-year cumulative survival of lung cancer is still 14%.
Materials and Methods: As a result of postoperative histopathological examination, the records of 207 patients who were evaluated as early stage (stage I and II) were retrospectively reviewed. We investigated the age, gender, respiratory functions, complaints, and postoperative complications, prognosis of the tumor stage and histopathologic type and the effects of survival in our study.
Results: Low grade tumors, gender, presence / absence of complaints during diagnosis, chest pain, hemoptysis, sputum, dyspnea and smoking history did not affect survival statistically. TNM stage and postoperative complications significantly affected the survival time.
Conclusion: Curative therapy in non-small cell lung cancer is surgery. The most important criteria
determining the prognosis of patients is stage.
Anahtar Kelimeler
Kaynakça
- Anthony B Miller. Lung Cancer, Epidemiology in Thoracic Surgery, Churchill Livingstone Inc.ed. F.G.Pearson 1995; 27: 648-60.
- Lynn T, Tanoue and Richard A Matthay. Lung Cancer, Epidemiology and carcinogenesis in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000; 93: 1215-28.
- Gail Darling and Carolyn M Dresler. Clinical Presentation of Lung Cancer in Thoracic Surgery, Churchill Livingstone Inc.ed. F.G.Pearson; 96: 1269-71.
- Cicero JL, Ponn RB, Daly DT. Surgical Treatment of nonsmall cell lung cancer in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000;99: 1311-41.
- Darling G, Dresler CM. Clinical presentation of lung cancer in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000; 96: 1269-82.
- Ginsberg RJ, Rubinstein L. For the Lung Cancer Study Group. Randomized trial of lobectomy versus limited resection for patients with T1N0 nonsmall cell lung cancer. Ann.Thorac Surg 1995; 60: 615-23.
- Steinbaum SS, Uretzky ID, McAdams HP. Exploratory thoracotomy for nonresectable lung cancer. Chest 1995 Apr; 107 (4): 1058-61.
- Watanabe Y, Tsubota M, Shimizu J et al. Aggressive surgical intervention in N2 nonsmall cell carcinoma of the lung with mediastinal lymph node metastasis. Ann Thorac Surg 1991; 51: 253.
- Myrdal G, Gustafsson G, Lambe M. Outcome after lung cancer surgery. Factors predicting early mortality and major morbidity. European Journal of Cardio-thoracic Surgery 2001; 20: 694-9.
- Fang D, Zhang D, Guojun H. Results of surgical resection of patients with primary lung cancer: T a retrospective analysis of 1905 cases. Ann Thorac Surg. 2001; 72: 1155-9.
- Tanaka F, Yanagihara K, Otake Y, et al. Prognostic factors in patients with resected pathologic (p-) T1- 2N1M0 non-small cell lung cancer. European Journal of cardio-thoracic surgery 2001; 19: 555-61.
- Cicero L, Ponn RB, Daly DT. Surgical Treatment of nonsmall cell lung cancer in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000;99: 1321-41.
- Ratto GB, Fabiano F, Rovida S. Survival after incomplete resection or exploratory thoracotomy in patients with advanced non small cell lung cancer. Ital J. Surg Sci. 1988; 18 (4): 377-83.
- Hara N, Ohta M, Tanaka K, Ichinose Y. Assessment of the role of surgery for stage III bronchogenic carcinoma. J. of surgical oncology 1984 Mar; 25 (3): 153-8.
- Bosch Den Van JM et al. Failure of preoperative staging to asssess unresectability in M0 bronchogenic carcinoma CANCER 1989; 63.
- Steinbaum SS, Uretzky ID, McAdams HP. Exploratory thoracotomy for nonresectable lung cancer. Chest 1995 Apr; 107 (4): 1058-61.
- TNM classification of malignant tumors. 5th ed. Willey-Liss, New York: 1997; 93-7.
- Travis WD, Colby TV, et al. World Health Organization International Histological Classification of Tumours. 2nd ed. Berlin-Heidelberg,1999.
- Watanabe Y, Hayashi, Shimizu J, Oda M, Iwa T. Mediastinal nodal involvement and the prognosis of nonsmall cell lung cancer. Chest 1991; 100: 423-8.
- Çıkrıkçıoğlu S, Kıyık M, S.Altın, Gürses A. Akciğer kanserinde prognostik faktörler ve tedavi öncesi değerlendirme. Akciğer kanseri multidisipliner yaklaşım, Toraks Derneği Ankara 1999; 80-96.
Rezeke edilen erken evre küçük hücreli dışı akciğer karsinomunda prognostik faktörler ve 10 yıllık sağ kalım
Öz
Amaç: Akciğer kanseri dünyada kanserden ölümlerin ilk sırasında yer almaktadır. Günümüzde yeni gelişen tanısal metotlara, ilerlemiş cerrahi tekniklere ve cerrahi dışı tedavi yöntemlerindeki gelişmelere rağmen, genel olarak akciğer kanserinin beş yıllık kümülatif sağ kalımı hala %14’tür.
Gereç ve Yöntem: Postoperatif histopatolojik inceleme sonucunda erken evre (Evre I - II) olarak değerlendirilen 207 olgunun kayıtları retrospektif olarak gözden geçirildi. Çalışmamızda olgularımızın yaş, cins, solunum fonksiyonları, şikayetleri, postoperatif komplikasyonlar, tümörün evresi ve histopatolojik tipinin prognoza ve sağ kalıma olan etkileri araştırılmıştır.
Bulgular: Çalışmamızda düşük evre tümörlerde cinsiyet, tanı sırasında şikâyeti olma/olmama durumu, göğüs ağrısı, hemoptizi, balgam, dispne ve sigara anamnezi sağ kalımı istatistiksel olarak etkilememiştir. TNM evresi ve postoperatif komplikasyon varlığı sağ kalım süresini anlamlı olarak etkilemiştir.
Sonuç: Küçük hücreli dışı akciğer kanserinde (KHDAK) küratif tedavi şekli cerrahidir. KHDAK’li hastaların prognozunu belirleyen en önemli kriter evredir.
Anahtar Kelimeler
Kaynakça
- Anthony B Miller. Lung Cancer, Epidemiology in Thoracic Surgery, Churchill Livingstone Inc.ed. F.G.Pearson 1995; 27: 648-60.
- Lynn T, Tanoue and Richard A Matthay. Lung Cancer, Epidemiology and carcinogenesis in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000; 93: 1215-28.
- Gail Darling and Carolyn M Dresler. Clinical Presentation of Lung Cancer in Thoracic Surgery, Churchill Livingstone Inc.ed. F.G.Pearson; 96: 1269-71.
- Cicero JL, Ponn RB, Daly DT. Surgical Treatment of nonsmall cell lung cancer in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000;99: 1311-41.
- Darling G, Dresler CM. Clinical presentation of lung cancer in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000; 96: 1269-82.
- Ginsberg RJ, Rubinstein L. For the Lung Cancer Study Group. Randomized trial of lobectomy versus limited resection for patients with T1N0 nonsmall cell lung cancer. Ann.Thorac Surg 1995; 60: 615-23.
- Steinbaum SS, Uretzky ID, McAdams HP. Exploratory thoracotomy for nonresectable lung cancer. Chest 1995 Apr; 107 (4): 1058-61.
- Watanabe Y, Tsubota M, Shimizu J et al. Aggressive surgical intervention in N2 nonsmall cell carcinoma of the lung with mediastinal lymph node metastasis. Ann Thorac Surg 1991; 51: 253.
- Myrdal G, Gustafsson G, Lambe M. Outcome after lung cancer surgery. Factors predicting early mortality and major morbidity. European Journal of Cardio-thoracic Surgery 2001; 20: 694-9.
- Fang D, Zhang D, Guojun H. Results of surgical resection of patients with primary lung cancer: T a retrospective analysis of 1905 cases. Ann Thorac Surg. 2001; 72: 1155-9.
- Tanaka F, Yanagihara K, Otake Y, et al. Prognostic factors in patients with resected pathologic (p-) T1- 2N1M0 non-small cell lung cancer. European Journal of cardio-thoracic surgery 2001; 19: 555-61.
- Cicero L, Ponn RB, Daly DT. Surgical Treatment of nonsmall cell lung cancer in General Thoracic Surgery, 5 th ed. Philadelphia: Lippincott Williams & Wilkins ed T.W.Shields; 2000;99: 1321-41.
- Ratto GB, Fabiano F, Rovida S. Survival after incomplete resection or exploratory thoracotomy in patients with advanced non small cell lung cancer. Ital J. Surg Sci. 1988; 18 (4): 377-83.
- Hara N, Ohta M, Tanaka K, Ichinose Y. Assessment of the role of surgery for stage III bronchogenic carcinoma. J. of surgical oncology 1984 Mar; 25 (3): 153-8.
- Bosch Den Van JM et al. Failure of preoperative staging to asssess unresectability in M0 bronchogenic carcinoma CANCER 1989; 63.
- Steinbaum SS, Uretzky ID, McAdams HP. Exploratory thoracotomy for nonresectable lung cancer. Chest 1995 Apr; 107 (4): 1058-61.
- TNM classification of malignant tumors. 5th ed. Willey-Liss, New York: 1997; 93-7.
- Travis WD, Colby TV, et al. World Health Organization International Histological Classification of Tumours. 2nd ed. Berlin-Heidelberg,1999.
- Watanabe Y, Hayashi, Shimizu J, Oda M, Iwa T. Mediastinal nodal involvement and the prognosis of nonsmall cell lung cancer. Chest 1991; 100: 423-8.
- Çıkrıkçıoğlu S, Kıyık M, S.Altın, Gürses A. Akciğer kanserinde prognostik faktörler ve tedavi öncesi değerlendirme. Akciğer kanseri multidisipliner yaklaşım, Toraks Derneği Ankara 1999; 80-96.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 30 Haziran 2020 |
| Gönderilme Tarihi | 23 Temmuz 2019 |
| Yayımlandığı Sayı | Yıl 2020 |