Prognostic factors in patients with recurrent squamous cell carcinoma of the vulva and the ınfluence of recurrence to the overall survival
Öz
Aim: The effects of many factors have been investigated in vulvar cancer patients with recurrence. In our study, we aimed to compare clinical and pathological factors and investigate the effect of recurrence on overall survival in patients with recurrent and non-recurrent squamous cell vulvar cancer.
Materials and Methods: The files of vulvar cancer patients who were operated in İzmir Tepecik Education and Research Hospital Gynecological Oncology Clinic between 1995 and 2018 and were followed up in our hospital were retrospectively reviewed. Patients were divided into two groups, with and without recurrence. The groups were compared in terms of age, stage, tumor size, midline status of the tumor, localization of the tumor, operation, surgical margin, depth of tumor invasion, presence of metastatic lymph node, adjuvant therapy variables and the effect of recurrence on survival was investigated.
Results: Variables such as age, stage, tumor size, midline status of the tumor, localization of the tumor, operation, surgical margin, tumor invasion depth, presence of metastatic lymph node, adjuvant therapy were not found to be statistically significant in terms of recurrent patients with vulvar cancer. There was also no correlation between recurrence and overall survival.
Conclusion: Many prognostic factors mentioned in the literature were not found to be significant in terms of recurrence in our study, and no difference was found between the groups with and without recurrence in terms of overall survival.
Anahtar Kelimeler
Kaynakça
- de Hullu JA, van der Zee AG. Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 2006; 60 (1): 38–58.
- Hacker NF, Eifel PJ, van dV. Cancer of the vulva. Int J Gynaecol Obstet 2012; 119 (2): 90-6.
- Baiocchi G, Silva Cestari FM, Rocha RM, Lavorato-Rocha A, Maia MB, Cestari LA, et al. Prognostic value of the number and laterality of metastatic inguinal lymph nodes in vulvar cancer: revisiting the FIGO staging system. Eur J Surg Oncol 2013; 39 (7): 780–5.
- Chan JK, Sugiyama V, Pham H, Gu M, Rutgers J, Osann K, et al. Margin distance and other clinico-pathologic prognostic factors in vulvar carcinoma: a multivariate analysis. Gynecol Oncol 2007; 104 (3): 636-41.
- Viswanathan AN, Pinto AP, Schultz D, Berkowitz R, Crum CP. Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma. Gynecol Oncol sept 2013; 130 (3): 545-9.
- Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol 2012; 83 (1): 71-83.
- Te Grootenhuis NC, Pouwer AFW, de Bock GH, Hollema H, Bulten J, et al. Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review. Gynecol Oncol. 2018; 148 (3): 622–31.
- Maggino T, Landoni F, Sartori E, Zola P, Gadducci A, Alessi C, et al. Patterns of recurrence in patients with squamous cell carcinoma of the vulva. A multicenter CTF Study. Cancer. 2000; 89 (1): 116–22.
- Woelber L, Eulenburg C, Choschzick M, Kruell A, Peterson C, Gieseking F, et al. Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment. Int J Gynecol Cancer. 2012; 22 (3): 503–8.
- Woelber L, Kock L, Gieseking F, Peterson C, Trillsch F, Choschzick M, et al. Clinical management of primary vulvar cancer. Eur J Cancer. 2011; 47 (15): 2315–21
- Heaps JM, Fu YS, Montz FJ, Hacker F, Berek JS. Surgicale pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990; 38: 309–14.
- de Hullu JA, Hollema H, Lolkema S, Boezen M, Boonstra H, Burger MP, et al. Vulvar carcinoma. The price of less radical surgery. Cancer 2002; 95: 2331–8.
- Baiocchi G, Mantoan H, de Brot L, Badiglian-Filho L, Kumagai LY, Faloppa CC, et al. How important is the pathological margin distance in vulvar cancer? Eur J Surg Oncol. 2015; 41 (12): 1653-8.
- National Dutch guideline gynaecologic tumors; Vulvar carcinoma. 2015. http://www.oncoline.nl.
- National Cancer Institute. Vulvar cancer treatment. 2015. http://www.cancer.gov/types/vulvar/h.
- Minar L, Felsinger M, Cihalova M, Zlamal F, Bienertova-Vasku J. Vulvar cancer recurrence an analysis of prognostic factors in tumour free pathological margins patients group. Ginekol Pol. 2018; 89 (8): 424-31
- Groenen SM, Timmers PJ, Burger CW. Recurrence rate in vulvar carcinoma in relation to pathological margin distance. Int J Gynecol Cancer 2010; 20: 869–73.
- Woelber L, Choschzick M, Eulenburg C, Hager M, Jaenicke F, Gieseking F, et al. Prognostic value of pathological resection margin distance in squamous cell cancer of the vulva. Ann Surg Oncol 2011; 18 (13): 3811–8.
- Karataşlı V, Erkılınç S, Çakır İ, Can B, Karadeniz T, Gökçü M, et al. The effect of lymph node metastasis onoverall survival and diseasefree survival in vulvar cancer patients. Ginekol Pol. 2020; 91 (2): 62-7.
- Podratz KC, Symmonds RE, Taylor WF. Carcinoma of the vulva: analysis of treatment failures. Am J Obstet Gynecol. 1982; 143: 340–51.
- Boyce J, Fruchter RG, Kasambilides E, Nicastri AD, Sedlis A, Remy JC. Prognostic factors in carcinoma of the vulva. Gynecol Oncol. 1985;20:364–377. doi: 10.1016/0090-8258(85)90218-5.
Nüks gelişen vulvar skuamöz hücreli kanser hastalarında prognostik faktörler ve nüksün toplam sağ kalıma etkisi
Öz
Amaç: Nüks gelişmiş olan vulvar kanser hastalarında birçok faktörün etkisi araştırılmıştır. Çalışmamızda nüks gelişen ve gelişmeyen skuamöz hücreli vulvar kanserli hastalarda klinik ve patolojik faktörlerin karşılaştırılması ve nüksün toplam sağ kalıma olan etkisini araştırmayı hedefledik.
Gereç ve Yöntem: İzmir Tepecik Eğitim ve Araştırma Hastanesi Jinekolojik Onkoloji Kliniği’nde 1995 - 2018 yılları arasında opere olmuş ve takipleri hastanemizde olan vulvar kanserli hastaların dosyaları retrospektif olarak tarandı. Hastalar nüks gelişmiş ve gelişmemiş olarak iki gruba ayrıldı. Yaş, evre, tümör boyutu, tümörün orta hat durumu, tümörün lokalizasyonu, yapılan operasyon, cerrahi sınır, tümörün invazyon derinliği, metastatik lenf nodu varlığı, adjuvan tedavi değişkenleri açısından gruplar karşılaştırıldı ve nüksün sağ kalıma olan etkisi araştırıldı.
Bulgular: Yaş, evre, tümör boyutu, tümörün orta hat durumu, tümörün lokalizasyonu, yapılan operasyon, cerrahi sınır, tümörün invazyon derinliği, metastatik lenf nodu varlığı, adjuvan tedavi gibi değişkenler vulvar kanserli hastalarda nüks gelişimi açısından istatiksel olarak anlamlı bulunmadı. Nüks ile toplam sağ kalım arasında da bir korelasyon bulunmadı.
Sonuç: Literatürde belirtilen birçok prognostik faktör çalışmamızda nüks açısından anlamlı bulunmamış olup, toplam sağ kalım açısından da nüks olan ve olmayan grup arasında bir fark saptanmamıştır.
Anahtar Kelimeler
Kaynakça
- de Hullu JA, van der Zee AG. Surgery and radiotherapy in vulvar cancer. Crit Rev Oncol Hematol 2006; 60 (1): 38–58.
- Hacker NF, Eifel PJ, van dV. Cancer of the vulva. Int J Gynaecol Obstet 2012; 119 (2): 90-6.
- Baiocchi G, Silva Cestari FM, Rocha RM, Lavorato-Rocha A, Maia MB, Cestari LA, et al. Prognostic value of the number and laterality of metastatic inguinal lymph nodes in vulvar cancer: revisiting the FIGO staging system. Eur J Surg Oncol 2013; 39 (7): 780–5.
- Chan JK, Sugiyama V, Pham H, Gu M, Rutgers J, Osann K, et al. Margin distance and other clinico-pathologic prognostic factors in vulvar carcinoma: a multivariate analysis. Gynecol Oncol 2007; 104 (3): 636-41.
- Viswanathan AN, Pinto AP, Schultz D, Berkowitz R, Crum CP. Relationship of margin status and radiation dose to recurrence in post-operative vulvar carcinoma. Gynecol Oncol sept 2013; 130 (3): 545-9.
- Gadducci A, Tana R, Barsotti C, Guerrieri ME, Genazzani AR. Clinico-pathological and biological prognostic variables in squamous cell carcinoma of the vulva. Crit Rev Oncol Hematol 2012; 83 (1): 71-83.
- Te Grootenhuis NC, Pouwer AFW, de Bock GH, Hollema H, Bulten J, et al. Prognostic factors for local recurrence of squamous cell carcinoma of the vulva: A systematic review. Gynecol Oncol. 2018; 148 (3): 622–31.
- Maggino T, Landoni F, Sartori E, Zola P, Gadducci A, Alessi C, et al. Patterns of recurrence in patients with squamous cell carcinoma of the vulva. A multicenter CTF Study. Cancer. 2000; 89 (1): 116–22.
- Woelber L, Eulenburg C, Choschzick M, Kruell A, Peterson C, Gieseking F, et al. Prognostic role of lymph node metastases in vulvar cancer and implications for adjuvant treatment. Int J Gynecol Cancer. 2012; 22 (3): 503–8.
- Woelber L, Kock L, Gieseking F, Peterson C, Trillsch F, Choschzick M, et al. Clinical management of primary vulvar cancer. Eur J Cancer. 2011; 47 (15): 2315–21
- Heaps JM, Fu YS, Montz FJ, Hacker F, Berek JS. Surgicale pathologic variables predictive of local recurrence in squamous cell carcinoma of the vulva. Gynecol Oncol 1990; 38: 309–14.
- de Hullu JA, Hollema H, Lolkema S, Boezen M, Boonstra H, Burger MP, et al. Vulvar carcinoma. The price of less radical surgery. Cancer 2002; 95: 2331–8.
- Baiocchi G, Mantoan H, de Brot L, Badiglian-Filho L, Kumagai LY, Faloppa CC, et al. How important is the pathological margin distance in vulvar cancer? Eur J Surg Oncol. 2015; 41 (12): 1653-8.
- National Dutch guideline gynaecologic tumors; Vulvar carcinoma. 2015. http://www.oncoline.nl.
- National Cancer Institute. Vulvar cancer treatment. 2015. http://www.cancer.gov/types/vulvar/h.
- Minar L, Felsinger M, Cihalova M, Zlamal F, Bienertova-Vasku J. Vulvar cancer recurrence an analysis of prognostic factors in tumour free pathological margins patients group. Ginekol Pol. 2018; 89 (8): 424-31
- Groenen SM, Timmers PJ, Burger CW. Recurrence rate in vulvar carcinoma in relation to pathological margin distance. Int J Gynecol Cancer 2010; 20: 869–73.
- Woelber L, Choschzick M, Eulenburg C, Hager M, Jaenicke F, Gieseking F, et al. Prognostic value of pathological resection margin distance in squamous cell cancer of the vulva. Ann Surg Oncol 2011; 18 (13): 3811–8.
- Karataşlı V, Erkılınç S, Çakır İ, Can B, Karadeniz T, Gökçü M, et al. The effect of lymph node metastasis onoverall survival and diseasefree survival in vulvar cancer patients. Ginekol Pol. 2020; 91 (2): 62-7.
- Podratz KC, Symmonds RE, Taylor WF. Carcinoma of the vulva: analysis of treatment failures. Am J Obstet Gynecol. 1982; 143: 340–51.
- Boyce J, Fruchter RG, Kasambilides E, Nicastri AD, Sedlis A, Remy JC. Prognostic factors in carcinoma of the vulva. Gynecol Oncol. 1985;20:364–377. doi: 10.1016/0090-8258(85)90218-5.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Yayımlanma Tarihi | 13 Haziran 2022 |
| Gönderilme Tarihi | 20 Mayıs 2021 |
| Yayımlandığı Sayı | Yıl 2022Cilt: 61 Sayı: 2 |
