Diyabetik sıçan overlerindeki glikoz hasarı ve NF-kappa B yolunun etkisi

Pala H G; Erbaş O; Oltulu F; Pala E; Aktuğ H; Yavaşoğlu A

Glucose injury in diabetic rats' ovaries and effect of NF-kappa B way

Year 2013, Volume: 52 Issue: 1, 32 - 36, 01.03.2013

Pala H G Erbaş O Oltulu F Pala E Aktuğ H Yavaşoğlu A

Abstract

Aim: To investigate glucose toxicity for ovarian damage severity and the effect of these by NF-kappa B way in rat models. Materials and Methods: An experimental diabetes mellitus model was created in seven rats. All seven rats, whose blood glucose levels were normal, were included in the control group. After eight weeks; bilateral oophorectomy was performed and the ovaries were researched histologically. The group characteristics were compared by one-way ANOVA and Mann Whitney U test. p values less than 0.05 were accepted as significant. Results: There was a significant increase of follicular degeneration, stromal degeneration, stromal fibrosis and NF-kappa B immune-expression in diabetic rats' ovary when compared to the control group of normal rats (p=0,0001). Conclusion: Our study shows that glucose toxicity occured severely in the ovaries and this injury originated in the NF-kappa B way in diabetes mellitus. Therefore, NF-kappa B inhibitors continue to be promising in preventing diabetic related tissue injury.

Keywords

Diabetes mellitus , premature ovarian failure , advanced glication end products , receptor of advanced glication end products , NF-kappa B.