COVID-19 hastalarında kırmızı hücre dağılım genişliği / albümin oranı ve laktat dehidrogenaz düzeyinin prognostik rolü

Burhan Sami Kalın; İhsan Solmaz

doi:10.19161/etd.1085634

EN TR

The prognostic role of red cell distribution width / albumin ratio and lactate dehydrogenase level in patients with COVID-19

Abstract

Aim: COVID-19 is an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 and one of the deadliest pandemic situation. Prognostic factors for the COVID-19 are not clearly established. Our primary objective is to evaluate the association between the mortality of COVID-19 and red cell distribution width (RDW)/albumin ratio and lactate dehydrogenase level (LDH).

Materials and Methods: The patients with laboratory or clinical and radiological confirmed COVID-19 infection from March to September 2020 were included. Patients were divided into two groups as the survivors and non-survivors and the differences between two groups were analysed for all parameters. Logistic regression analysis was performed to assign the independent risk factors for mortality.

Results: The study was performed in 1900 cases confirmed by COVID-19 infection. Mortality rate was 5%. Non-survivors had higher LDH and RDW/albumin ratio as compared to survivors (387 [270-545] vs. 236[194-292], p=0.001 and 8.3 [6.5-9.2] vs. 3.4 [3.1-3.9], p=0.001), respectively). In the binary logistic regression analysis, RDW/albumin ratio, LDH, cerebrovascular disease, congestive heart failure and coronary artery disease were found to be independent risk factors for mortality.

Conclusion: LDH and RDW/albumin ratio can be favorable prognostic biomarkers for predicting in hospital mortality in patients with COVID-19 but more studies need to confirm the clinical value associated with illness.

Keywords

COVID-19 hastalarında kırmızı hücre dağılım genişliği / albümin oranı ve laktat dehidrogenaz düzeyinin prognostik rolü

Öz

Amaç: COVID-19, şiddetli akut solunum sendromu koronavirüs 2'nin neden olduğu bulaşıcı bir hastalıktır ve en ölümcül pandemik durumlardan birisidir. COVID-19 için prognostik faktörler net olarak belirlenmemiştir. Bu çalışmada, COVID-19 mortalitesi ile kırmızı hücre dağılım genişliği (RDW) / albümin oranı ve laktat dehidrogenaz seviyesi (LDH) arasındaki ilişkinin değerlendirilmesi amaçlanmıştır.

Gereç ve Yöntem: Mart - Eylül 2020 tarihleri arasında laboratuvar veya klinik ve radyolojik olarak doğrulanmış COVID-19 enfeksiyonu olan hastalar çalışmaya dâhil edildi. Hastalar, sağ kalanlar ve ölenler olarak iki gruba ayrıldı ve iki grup arasındaki farklılıklar tüm parametreler için analiz edildi. Mortalite açısından bağımsız risk faktörlerini belirlemek için lojistik regresyon analizi yapıldı.

Bulgular: Çalışma, COVID-19 enfeksiyonu doğrulanan 1900 vaka üzerinde gerçekleştirildi. Ölüm oranı %5’idi. Ölen hastalar, sağ kalanlara kıyasla daha yüksek LDH ve RDW / albümin oranına sahipti (387 [270-545] ve 236 [194-292], p=0.001 ve 8,3 [6,5-9,2] ve 3,4 [3,1-3,9], p=0,001), sırası ile). Lojistik regresyon analizinde RDW/albümin oranı, LDH, serebrovasküler hastalık, konjestif kalp yetmezliği ve koroner arter hastalığı mortalite açısından bağımsız risk faktörleri olarak bulundu.

Sonuç: LDH ve RDW / albümin oranı, COVID-19 hastalarında hastane mortalitesini tahmin etmek için prognostik biyobelirteçler olabilir ancak bu parametrelerin klinik değerlerinin daha fazla çalışma ile doğrulanması gerekir.

Anahtar Kelimeler

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Burhan Sami Kalın ^*
0000-0003-2624-6175
Türkiye

İhsan Solmaz
0000-0002-6624-8063
Türkiye

Publication Date

March 15, 2022

Submission Date

April 30, 2021

Acceptance Date

August 3, 2021

Published in Issue

Year 2022 Volume: 61 Number: 1

DOI

https://doi.org/10.19161/etd.1085634

IZ

https://izlik.org/JA43TM74AM

Cite

RIS / Bibtex

Vancouver

1.Burhan Sami Kalın, İhsan Solmaz. COVID-19 hastalarında kırmızı hücre dağılım genişliği / albümin oranı ve laktat dehidrogenaz düzeyinin prognostik rolü. EJM. 2022 Mar. 1;61(1):38-43. doi:10.19161/etd.1085634