The predictive role of preoperative full blood count markers and the De-Ritis ratio in the diagnosis of testicular tumor

Hakan Bahadır Haberal Haberal; Kubilay Sarıkaya; Fahri Erkan Sadioğlu; Muhammed Arif İbiş; Çağrı Şenocak; Ömer Faruk Bozkurt

doi:10.19161/etd.1125252

TR EN

Preoperatif tam kan sayımı belirteçleri ve De-Ritis oranının testis tümörünün tanısındaki prediktif yeri

Öz

Amaç: Preoperatif tam kan ve biyokimyasal parametrelerden nötrofil-lenfosit oranı (NLO), trombosit-lenfosit oranı (TLO), lenfosit-monosit oranı (LMO), sistemik immün-inflamasyon (SII) indeksi ve De-Ritis oranının testis tümörü tanısındaki yerinin belirlenmesi.

Gereç ve Yöntem: Ekim 2010 ile Aralık 2019 tarihleri arasında kliniğimizde testis tümörü nedeniyle inguinal orşiektomi yapılan hastaların ve kontrol grubu olarak varikoselektomi yapılan hastaların verileri retrospektif olarak incelendi. Verileri eksik olan, 18 yaşın altında olan veya ek morbiditesi olan hastalar çalışma dışında bırakıldı. NLO, TLO, LMO, SII indeksi ve De-Ritis oranı için kestirim değerleri belirlendi ve bu parametrelerin testis tümörü tanısındaki yeri incelendi.

Bulgular: Çalışmaya dahil edilen hastaların 34’ünü (%14,1) testis tümörlü hastalar, 207’sini (%85,9) varikoselektomi yapılan hastalar oluşturmaktaydı. Hastaların ameliyat esnasındaki ortanca yaşlarının 27 (23-32) yıl olduğu görüldü. Testis tümörlü hastaların 18’inde (%52,9) seminom, 12’sinde (%35,3) mikst germ hücreli tümör, 3’ünde (%8,8) yolk sac tümörü ve 1’inde (%2.9) embriyonel karsinom izlendi. Testis tümörlü hastaların %61,8’inin T2 evresinde ve %35,3’ünde metastaz olduğu belirlendi. NLO, TLO, LMO ve SII indeksi için sırasıyla kestirim değerleri 1,76, 133,43, 7,81 ve 571,63 olarak belirlendi. De-Ritis oranı için istatistiksel olarak anlamlı bir kestirim değeri bulunamadı (p=0.183). Çok değişkenli analiz yapıldığında, sadece SII indeksinin testis tümörünün öngörülmesinde anlamlı olduğu görüldü (p<0.001).

Sonuç: SII indeksi testis tümörü tanısında kullanılabilecek prediktif bir faktördür.

Anahtar Kelimeler

The predictive role of preoperative full blood count markers and the De-Ritis ratio in the diagnosis of testicular tumor

Abstract

Aim: To determine the value of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), systemic immune-inflammation (SII) index and De-Ritis ratio, which are among preoperative whole blood and biochemical parameters, in the diagnosis of testicular tumor.

Materials and Methods: The data of patients who underwent inguinal orchiectomy for testicular tumor in our clinic between October 2010 and December 2019 and patients who underwent varicocelectomy, as a control group, were retrospectively analyzed. Patients with missing data, under 18 years of age or with additional morbidity were excluded from the present study. Prediction values for NLR, PLR, LMR, SII index and De-Ritis ratio were determined and the value of these parameters in the diagnosis of testicular tumor was examined.

Results: Thirty-four (14.1%) patients underwent inguinal orchiectomy while 207 (85.9%) patients underwent varicocelectomy in the present study. The median age of the patients during surgery was 27 (23-32) years. The number of patients with seminoma, mixt germ cell tumor, yolk sac tumor and embryonal carcinoma was 18 (52.9%), 12 (35.3%), 3 (8.8%) and 1 (2.9%), respectively. It was determined that 61.8% of the patients with testicular tumors were in the T2 stage and 35.3% had metastasis. The cut-off values for NLR, PLR, LMR and SII index were determined as 1.76, 133.43, 7.81 and 571.63, respectively. There was no statistically significant cut-off value for De-Ritis ratio (p = 0.183). The only significant factor for predicting testicular tumor was SII index in multivariate analysis (p <0.001).

Conclusion: SII index is a predictive factor that can be used in the diagnosis of testicular tumor.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Hakan Bahadır Haberal Haberal ^*
0000-0001-9774-2040
Türkiye

Kubilay Sarıkaya
0000-0003-1734-2392
Türkiye

Fahri Erkan Sadioğlu
0000-0002-4454-0274
Türkiye

Muhammed Arif İbiş
0000-0001-8581-2101
Türkiye

Çağrı Şenocak
0000-0001-5696-6320
Türkiye

Ömer Faruk Bozkurt
0000-0002-6684-5431
Türkiye

Publication Date

June 13, 2022

Submission Date

August 18, 2021

Acceptance Date

November 11, 2021

Published in Issue

Year 2022 Volume: 61 Number: 2

DOI

https://doi.org/10.19161/etd.1125252

IZ

https://izlik.org/JA76NC98GG

Cite

RIS / Bibtex

Vancouver

1.Hakan Bahadır Haberal Haberal, Kubilay Sarıkaya, Fahri Erkan Sadioğlu, Muhammed Arif İbiş, Çağrı Şenocak, Ömer Faruk Bozkurt. The predictive role of preoperative full blood count markers and the De-Ritis ratio in the diagnosis of testicular tumor. EJM. 2022 Jun. 1;61(2):145-50. doi:10.19161/etd.1125252

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