The relationship between neutrophil lymphocyte ratio and diabetes control in patients with type 2 diabetes mellitus

Hatice Özışık; Şevki Çetinkalp; Aslı Suner; Gökhan Özgen; Füsun Saygılı; Mehmet Erdoğan

doi:10.19161/etd.1168234

TR EN

Tip 2 diabetes mellituslu hastalarda nötrofil lenfosit oranı ile diyabet kontrolü arasındaki ilişki

Öz

Amaç Diabetik hastalarda Nötrofil lenfosit oranı ve glikoz kontrolü arasındaki ilişkiyi araştırmayı amaçladık. Ortalama Trombosit Hacmi (MPV), Kırmızı kan hücre dağılımı (RDW), mikroalbüminüri ve glikozile hemoglobin (HbA1c) arasındaki korelasyonları ortaya koymayı amaçladık. Yöntem Bu çalışma Ege Üniversitesi Tıp Fakültesi Endokrinoloji Anabilim Dalı'nda gerçekleştirilen retrospektif bir çalışmadır. Tip 2 diabetes mellituslu 198 hastanın tıbbi kayıtlarını aldık ve bunlar iki gruba ayrıldı; Kontrollü diabetes mellituslu hastalar (Hba1c≤%7) (n=82) ve kontrolsüz diabetes mellituslu hastalar (Hba1c>%7) (n=116) Sonuçlar NLR, RDW ve MPV'de iki grupta anlamlı fark yoktu (sırasıyla p=0,123'e karşı p=0,298, p=0,595). İki grup arasında 5 yıl ve altı ve 5 yıl üstü diabetes mellitus süresi istatistiksel olarak anlamlıydı (p=0,002). NLR, kontrolsüz DM'de kontrollü DM'den daha yüksek bulundu, ancak istatistiksel olarak anlamlı değildi. NLR, RDW, MPV, WBC'nin ROC eğrisi analizi istatistiksel olarak anlamlı bulunmadı (p>0.05). Sonuç WBC seviyelerindeki yükselmeler diyabet kontrolü ile ilişkili olabilir. Diabetes mellitusun süresi mikroalbüminüriyi öngörebilir. Çalışmamız diyabetes mellitus süresinin mikroalbüminüriyi öngörebileceğini oarta çıkardı ve çalışmamızda T2DM'li hastalarda NLR, RDW, MPV ve Hba1c, mikroalbüminüri arasındaki ilişkiyi değerlendirdik.

Anahtar Kelimeler

The relationship between neutrophil lymphocyte ratio and diabetes control in patients with type 2 diabetes mellitus

Abstract

Purpose The current study was to investigate the association of NLR and the control of glucose. We also aimed to reveal correlations between Mean Platelet Volume (MPV), Red blood cell distribution (RDW), microalbuminuria and glycosylated hemoglobin (HbA1c). Methods This study was a retrospective study conducted in Ege University Faculty of Medicine Endocrinology Department. We obtained the medical records of 198 patients with type 2 diabetes mellitus and they were divided into two groups; patients with controlled diabetes mellitus (Hba1c≤7 %) (n=82) and patients with uncontrolled diabetes mellitus (Hba1c>7 %) (n=116) Results There were no significant differences in NLR, RDW and MPV in two groups (p=0.123 vs. p=0.298, p=0.595 respectively). Duration of diabetes mellitus 5 years and below and after 5 years between two groups was statistically significant (p=0.002). NLR was found higher in uncontrolled DM than controlled DM, but not statistically significant. Receiver operating characteristic curve analysis of NLR, RDW, MPV, WBC were found not statistically significant (p>0.05). Conclusion Elevations of WBC levels may be related with diabetes control. Duration of diabetes mellitus may predict microalbuminuria. Our study revealed that duration of diabetes mellitus may predict microalbuminuria, and the present study evaluated the relationship between NLR, RDW, MPV and Hba1c, microalbuminuria together in the patients with T2DM.

Keywords

Supporting Institution

yok

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Hatice Özışık ^*
0000-0003-4336-814X
Türkiye

Şevki Çetinkalp
0000-0001-6072-2062
Türkiye

Aslı Suner
0000-0002-6872-9901
Türkiye

Gökhan Özgen
0000-0003-0533-3122
Türkiye

Füsun Saygılı
0000-0002-4451-6530
Türkiye

Mehmet Erdoğan
0000-0002-0300-3923
Türkiye

Publication Date

September 12, 2022

Submission Date

June 8, 2022

Acceptance Date

July 26, 2022

Published in Issue

Year 2022 Volume: 61 Number: 3

DOI

https://doi.org/10.19161/etd.1168234

IZ

https://izlik.org/JA58GX89NW

Cite

RIS / Bibtex

Vancouver

1.Hatice Özışık, Şevki Çetinkalp, Aslı Suner, Gökhan Özgen, Füsun Saygılı, Mehmet Erdoğan. The relationship between neutrophil lymphocyte ratio and diabetes control in patients with type 2 diabetes mellitus. EJM. 2022 Sep. 1;61(3):444-51. doi:10.19161/etd.1168234

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