Could diabetes mellitus be a risk factor for postoperative hypoparathyroidism?

Bülent Can; Zubeyr Said Agaç; Zeynep Çetin

doi:10.19161/etd.1127370

EN TR

Could diabetes mellitus be a risk factor for postoperative hypoparathyroidism?

Abstract

Aim: Postoperative hypoparathyroidism (postop hypoPT) is usually seen after aggressive neck surgery, and can be fatal if left untreated. To the best our knowledge there is no study in literature that directly investigates the association between diabetes mellitus (DM) and postop hypoPT. In this study, we aimed to determine whether DM increases the risk of permanent postop hypoPT.

Materials and Methods: Patients presenting to endocrinology outpatient clinic with a diagnosis of permanent postoperative hypoparathyroidism, were studied retrospectively. Patients older than 18 years of age were included in the study if one year had passed after the neck operation.

Results: The average age of 131 patients who met the inclusion criteria was 49 ± 12. 93.9% of the patients were women and the patients were generally obese or overweight (mean body mass index= 30±5.29 kg/m2). While 14.5% of the patients were diabetic and 32.8% prediabetic (47.3% had impaired carbohydrate tolerance), 52.7% had normal glucose metabolism.

Conclusion: The rate of DM / prediabetes (preDM) in patients diagnosed with postop hypoPT and the prevalence of DM / preDM in Turkish population were similar. Even though DM is associated with endothelial dysfunction, our findings suggest that DM is not a risk factor for postop hypoPT.

Keywords

Diabetes mellitus postoperatif hipoparatiroidizm için bir risk faktörü olabilir mi?

Öz

Amaç: Postoperatif hipoparatiroidizm (postop hipoPT) genellikle agresif boyun cerrahisinden sonra görülür ve tedavi edilmezse ölümcül olabilir. Bildiğimiz kadarıyla literatürde diabetes mellitus (DM) ile postop hipoPT arasındaki ilişkiyi doğrudan araştıran bir çalışma bulunmamaktadır. Bu çalışmada DM'nin kalıcı postop hipoPT riskini artırıp artırmadığını belirlemeyi amaçladık.

Gereç ve Yöntem: Endokrinoloji polikliniğine postoperatif kalıcı hipoparatiroidizm tanısı ile başvuran hastalar retrospektif olarak incelendi. Boyun ameliyatının üzerinden en az bir yıl geçmiş olan 18 yaş üstü hastalar çalışmaya dâhil edildi.

Bulgular: Dâhil edilme kriterlerine uyan 131 hastanın yaş ortalaması 49 ± 12 idi. Hastaların %93,9'u kadındı ve hastalar genel olarak obez veya fazla kiloluydu (ortalama vücut kitle indeksi= 30±5,29 kg/m2). Hastaların %14,5'i diyabetik ve %32,8'i prediyabetik (%47,3'ü bozulmuş karbonhidrat toleransına sahipti), %52,7'si normal glukoz metabolizmasına sahipti.

Sonuç: Postop hipoPT tanısı alan hastalarda DM / prediyabet (preDM) sıklığı ile Türk popülasyonunda DM / preDM prevalansı benzerdi. Diyabet, endotel disfonksiyonu ile ilişkili olmasına rağmen, çalışmamızdaki bulgular DM'nin postop hipoPT için bir risk faktörü olmadığını düşündürmektedir.

Anahtar Kelimeler

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Bülent Can ^*
0000-0001-6382-1306
Türkiye

Zubeyr Said Agaç
0000-0001-8470-7502
Türkiye

Zeynep Çetin
0000-0001-7824-4644
Türkiye

Publication Date

June 13, 2022

Submission Date

September 22, 2021

Acceptance Date

January 16, 2022

Published in Issue

Year 2022 Volume: 61 Number: 2

DOI

https://doi.org/10.19161/etd.1127370

IZ

https://izlik.org/JA79TA65UF

Cite

RIS / Bibtex

Vancouver

1.Bülent Can, Zubeyr Said Agaç, Zeynep Çetin. Could diabetes mellitus be a risk factor for postoperative hypoparathyroidism? EJM. 2022 Jun. 1;61(2):269-75. doi:10.19161/etd.1127370