Evaluation of cardiovascular disease risk factors, inflammatory markers and subclinical atherosclerosis in patients with hemophilia

Sukriye Miray Kilincer Bozgul; Fatoş Dilan Atilla; Güneş Ak; Uğur Önsel Türk; Burcu Barutcuoğlu; Güray Saydam; Fahri Şahin

doi:10.19161/etd.1208982

TR EN

Hemofili hastalarında kardiyovasküler hastalık risk faktörlerinin, inflamatuar belirteçlerin ve subklinik aterosklerozun değerlendirilmesi

Öz

Amaç: Türkiye'de tek merkezli bir çalışmada hemofili hastaları ile sağlıklı kontroller arasında kardiyovasküler hastalık (KVH) risk faktörlerini değerlendirmek ve karşılaştırmak. Gereç ve Yöntem: Boy, kilo ve vücut kitle indeksi gibi antropometrik parametreler kaydedildi. Açlık glukozu, HbA1c, yüksek duyarlıklı C-Reaktif Protein (hs-CRP), adiponektin, lipid parametreleri (total kolesterol, HDL-kolesterol, LDL-kolesterol, trigliserit) değerlendirildi. Uluslararası Fiziksel Aktivite Anketi (IPAQ) ve karotis intima media kalınlık (KIMK) ölçümleri yapıldı. Hemofili (n=80) ve sağlıklı kontrollerden (n=36) elde edilen veriler karşılaştırıldı. KIMK değerinin bağımsız değişkenleri analiz edildi. Bulgular: Hipertansiyon, diabetes mellitus, metabolik sendrom ve sigara içme sıklığı hemofili hastalarında dikkat çekiciydi. Ailede KVH öyküsü anlamlı olarak daha sıktı ( p=0,005) ve IPAQ skorları ile değerlendirildiğinde; hemofili hastaları, kontrollere göre daha sedantardi (p<0,001). Total kolesterol, LDL-kolesterol kontrol grubunda anlamlı olarak daha yüksekti (p =0.003,=0.003), hs-CRP seviyeleri ise hemofili hastalarında daha yüksekti (p=0.009). Yaş ve IPAQ skoru KIMK'nin anlamlı bağımsız belirleyicileri (sırasıyla p=0,004 ve 0,003). Sonuç: Yaşlanma sonucunda; hemofili hastaları genel popülasyonla aynı KVH risk faktörlerine maruz kalmaktadır. Hemofili değerlendirmesi dışında; KVH risk faktörlerinin taranması da gerekli olacaktır.

Anahtar Kelimeler

Evaluation of cardiovascular disease risk factors, inflammatory markers and subclinical atherosclerosis in patients with hemophilia

Abstract

Aim: To assess and compare the risk factors of cardiovascular disease (CVD) between patients with hemophilia (PwH) and healthy controls in a single center cohort in Türkiye.

Materials and Methods: Anthropometric parameters including height, weight, and body mass index were recorded. Fasting glucose, HbA1c, high sensitive C-Reactive Protein (hs-CRP), adiponectin, lipid parameters (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) were assessed. International Physical Activity Questionnaires (IPAQ) and carotid intima media thickness (CIMT) measurements were performed. The data from PwH (n=80) and healthy controls (n=36) were compared. Independent associates of CIMT value were analyzed.

Results: Hypertension, diabetes mellitus, metabolic syndrome and smoking frequencies were remarkable in PwH. Family history of CVD was significantly more frequent ( p=0.005) and when considered with IPAQ scores; PwH was much more sedentary than controls (p<0.001). Total cholesterol, LDL-cholesterol were significantly higher in the control group (p =0.003,=0.003) while hs-CRP levels were higher in PwH (p=0.009). Age and IPAQ score were significant independent predictors of CIMT (p=0.004 and 0.003, respectively).

Conclusion: As a result of aging; PwH exposure to the same CVD risk factors as the general population. Screening for CVD risk factors in PwH other than hemophilia evaluation will be essential.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Sukriye Miray Kilincer Bozgul ^*
0000-0002-3995-5096
Türkiye

Fatoş Dilan Atilla
0000-0002-3947-0355
Türkiye

Güneş Ak
0000-0001-6780-1812
Türkiye

Uğur Önsel Türk
0000-0001-6348-6616
Türkiye

Burcu Barutcuoğlu
0000-0001-6570-5229
Türkiye

Güray Saydam
0000-0001-8646-1673
Türkiye

Fahri Şahin
0000-0001-9315-8891
Türkiye

Publication Date

December 12, 2022

Submission Date

April 1, 2022

Acceptance Date

May 9, 2022

Published in Issue

Year 2022 Volume: 61 Number: 4

DOI

https://doi.org/10.19161/etd.1208982

IZ

https://izlik.org/JA78CR36EZ

Cite

RIS / Bibtex

Vancouver

1.Sukriye Miray Kilincer Bozgul, Fatoş Dilan Atilla, Güneş Ak, Uğur Önsel Türk, Burcu Barutcuoğlu, Güray Saydam, Fahri Şahin. Evaluation of cardiovascular disease risk factors, inflammatory markers and subclinical atherosclerosis in patients with hemophilia. EJM. 2022 Dec. 1;61(4):549-57. doi:10.19161/etd.1208982