Treatment results of our patients with acute viral hepatitis C

Abdullah Umut Pekok; Ahmet Yabalak; Sedef Tavukçu Özkan; Metin Kement; Mehmet Pekok; Berfin Sude Pekok

doi:10.19161/etd.1307217

TR EN

Akut Hepatit C hastalarımızın tedavi sonuçları

Öz

Amaç: Akut hepatit C virüs (HCV) enfeksiyonu tanısı, çoğunlukla asemptomatik seyrettiği için genel olarak bilinen bir risk teması olan hastalarda takip sırasında konulabilmektedir. Akut HCV enfeksiyonunun en erken göstergesi artmış HCV-RNA'dır. Anti-HCV serokonversiyonu da akut enfeksiyonun en güçlü kanıtıdır. Kronikleşme riski en az %80'dir. Akut HCV enfeksiyonunun tedavisi, yüksek kronikleşme oranı nedeniyle önerilmektedir. Akut viral hepatit C'de 8-12 hafta sonra spontan iyileşme görülebilmektdir. Bu nedenle spesifik tedaviye başlamak için 8-12 hafta beklenmesi önerilmektedir. Bu çalışmada kendi kliniğimizde akut HCV tanısı ile takip ettiğimiz hastaların verilerini değerlendirerek akut viral hepatit C’de en uygun tedavi başlama zamanını saptamak ve Peg-interferon alfa 2a’nın akut viral hepatit C vakaları üzerindeki etkisini değerlendirmek amacıyla yapılmıştır. Gereç ve Yöntem: 2005 ile 2015 yılları arasında kliniğimizde akut viral hepatit C tanısı almış olan hastaların verileri değerlendirildi. Bulgular: Akut viral hepatit C'li 12 hasta kliniğimizde takip edildi. Olguların 12'si de erkek olup, yaş ortalaması 38,83 ±6,75 (aralık, 25-50) yıl idi. Üçüncü ayda üç hastada spontan klirens gözlendi. Akut HCV tanısından üç ay sonra, spontan düzelme olmayan dokuz hastaya pegile interferon alfa 2a 180 mcg (1x1/hafta sc) başlandı ve altı ay tedavi uygulandı. 6 aylık ve 2 yıllık takiplerinde tedavi yanıtı %100’dü. Sonuç: Akut viral hepatit C, tanısı atlanmaması gereken bir hastalıktır. Tanı konulduktan sonra spontan viral klerens için 8-12 hafta beklenmelidir. 8-12 hafta sonra spontan viral klerens gelişmeyen hastalar, interferon alfa 2a tedavisi ile büyük ölçüde tedavi edilebilmektedirler. 8-12 haftalık takip sonrasında üç hastamızda spontan düzelme gözlendi (HCV-RNA PCR ile negatif, AST-ALT değerleri normaldi).

Anahtar Kelimeler

Treatment results of our patients with acute viral hepatitis C

Abstract

Aim: The diagnosis of acute hepatitis C virus (HCV) infection can be made during follow-up in patients with a generally known risk contact, as it is mostly asymptomatic. The earliest indicator of acute HCV infection is increased HCV-RNA. Anti-HCV seroconversion is also the strongest evidence of acute infection. The risk of chronicity is at least 80%. Treatment of acute HCV infection is recommended because of the high rate of chronicity. Spontaneous recovery can be seen after 8-12 weeks in acute viral hepatitis C. Therefore, 8-12 weeks should be waited to start specific treatment. The aim of this study is to evaluate the data of the patients we follow up with the diagnosis of acute HCV in our clinic, to determine the most appropriate time to start treatment in acute viral hepatitis C and to evaluate the effectiveness of Peg-interferon alfa 2a treatment. Materials and Methods: The data of patients diagnosed with acute viral hepatitis C in our clinic between 2005 and 2015 were evaluated. Results: Twelve patients with acute viral hepatitis C were followed in our clinic. Twelve of the cases were male, and the mean age was 38.83 ± 6.75 (range, 25-50) years. Spontaneous clearance was observed in three patients at the third month. Three months after the acute diagnosis of HCV, pegylated-interferon alpha 2a 180 mcg (1x1 / week sc) was started in nine patients without spontaneous improvement and treatment was performed for six months. Treatment response was 100% at 6-month and 2-year follow-ups. Conclusion: Acute viral hepatitis C is a disease that should not be overlooked. After diagnosis, 8-12 weeks should be waited for spontaneous viral clearance. Patients who do not develop spontaneous viral clearance after 8-12 weeks can be largely treated with interferon alfa 2a therapy. Spontaneous recovery was observed in three of our patients after 8-12 weeks of follow-up (HCV-RNA was negative by PCR, AST-ALT values were normal).

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Abdullah Umut Pekok ^*
0000-0002-5031-7298
Türkiye

Ahmet Yabalak
0000-0002-3317-9567
Türkiye

Sedef Tavukçu Özkan
0000-0003-3573-7902
Türkiye

Metin Kement
0000-0003-4724-4945
Türkiye

Mehmet Pekok
0000-0002-2751-8921
Türkiye

Berfin Sude Pekok
0000-0003-4927-3440
Türkiye

Publication Date

March 19, 2024

Submission Date

May 30, 2023

Acceptance Date

August 8, 2023

Published in Issue

Year 2024 Volume: 63 Number: 1

DOI

https://doi.org/10.19161/etd.1307217

IZ

https://izlik.org/JA43RB36ML

Cite

RIS / Bibtex

Vancouver

1.Abdullah Umut Pekok, Ahmet Yabalak, Sedef Tavukçu Özkan, Metin Kement, Mehmet Pekok, Berfin Sude Pekok. Treatment results of our patients with acute viral hepatitis C. EJM. 2024 Mar. 1;63(1):71-7. doi:10.19161/etd.1307217