Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line

Kubilay Doğan Kılıç; Ayşenur Kayabaş Avşar; Cemre Özkanca; Dila Hatun Sal; Fatih Karabey; Zeynep Simge Yılmaz; Yiğit Uyanıkgil

doi:10.19161/etd.1441204

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Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line

Abstract

Objective: The aim of this study was to investigate the cytotoxic effect of Helianthem germanicopolitanum Bornm., a rare endemic plant in Turkey, against colon cancer. Materials and Methods: After the extraction of Helianthemum germanicopolitanum Bornm. plant, the phytochemical profile of the plant was analyzed by High Performance Liquid Chromatography (HPLC). Cytotoxicity analysis on HT-29 human colon cancer cell line was performed by WST 1 assay. The results were compared with other studies on similar plant species in the literature. Results: H. germanicopolitanum plant contains various flavonoids and these flavonoids have cytotoxic effects on colorectal cancer cells. These cytotoxic effects provide anticarcinogenic effects by activating cell death pathways at certain concentrations. These findings provide an important insight into the therapeutic potential of the plant. Conclusion: Cytotoxicity studies of flavonoids in extracts obtained from extraction procedures on colorectal cancer cell lines show that flavonoids offer anticarcinogenic effects by activating cell death pathways at certain concentrations.

Keywords

References

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Details

Primary Language

English

Subjects

Cancer Cell Biology , Cancer Therapy (Excl. Chemotherapy and Radiation Therapy)

Journal Section

Research Article

Authors

Kubilay Doğan Kılıç ^*
0000-0002-9484-0777
Türkiye

Ayşenur Kayabaş Avşar
0000-0003-3555-4399
Türkiye

Cemre Özkanca
0000-0002-0342-2060
Türkiye

Dila Hatun Sal
0009-0007-3840-6347
United Kingdom

Fatih Karabey
0000-0003-0305-6192
Türkiye

Zeynep Simge Yılmaz
0000-0002-1460-8530
Türkiye

Yiğit Uyanıkgil
0000-0002-4016-0522
Türkiye

Publication Date

September 9, 2024

Submission Date

February 26, 2024

Acceptance Date

May 30, 2024

Published in Issue

Year 1970 Volume: 63 Number: 3

DOI

https://doi.org/10.19161/etd.1441204

IZ

https://izlik.org/JA85FL59BA

Cite

RIS / Bibtex

Vancouver

1.Kubilay Doğan Kılıç, Ayşenur Kayabaş Avşar, Cemre Özkanca, Dila Hatun Sal, Fatih Karabey, Zeynep Simge Yılmaz, Yiğit Uyanıkgil. Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line. EJM. 2024 Sep. 1;63(3):441-8. doi:10.19161/etd.1441204

Cited By

Endemic Plant Helianthemum germanicopolitanum Bornm. (Cistaceae) in Gypsum Habitats: Exploring its Elemental Composition and Antioxidant Properties

European Journal of Biology

https://doi.org/10.26650/EurJBiol.2026.1794863

Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line

Cytotoxicity assay of Turkish rare endemic Helianthemum germanicopolitanum Bornm. plant extract on HT-29 cell line

Abstract

Keywords

Türkiye’nin Nadir Endemiği Helianthemum germanicopolitanum Bornm. Bitki Ekstraktının HT-29 Hücre Hattı Üzerindeki Sitotoksisite Analizi

Öz

Anahtar Kelimeler

References

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Subjects

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Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

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IZ

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Cited By

Endemic Plant Helianthemum germanicopolitanum Bornm. (Cistaceae) in Gypsum Habitats: Exploring its Elemental Composition and Antioxidant Properties