Prevalence of metabolic syndrome patıents with systemic sclerosis

Ümit Özmen; Elif Er Gülbezer; Burcu Barutcuoğlu; Figen Yargucu Zihni

doi:10.19161/etd.1532789

EN TR

Prevalence of metabolic syndrome patıents with systemic sclerosis

Abstract

Objective: To determine the prevalence of metabolic syndrome (MetS) in Turkish systemic sclerosis (SSc) patients. Materials and Methods: In this cross-sectional, single-centre study, 76 SSc patients admitted to the outpatient clinic of our tertiary care hospital between July and September 2021 were included. The National Cholesterol Education Programme's Adult Treatment Panel (NCEP-ATP III) criteria were used to define metabolic syndrome (MetS). The relationship between MetS and SSc organ involvement and disease characteristics was investigated. Results: According to the ATP III criteria, 37 cases (48.7%) were identified as having MetS. The prevalance of MetS increased with advancing age (40-45 years: 25%, 46-60 years: 48.4%, >60 years: 62.9%). The cases were divided into two groups according to the presence or absence of MetS. Patients with MetS had higher mean age (58.2±9.4 vs. 51.6±13.5, p=0.015) and lower modified Rodnan skin scores (14 vs. 22, p=0.019). The groups were comparable regarding disease subtype, duration and activity, organs/systems involved and disease-related damage. Conclusion: Although the prevalence of MetS in SSc patients in our study was higher than that observed in the general population of our country, the prevalence of MetS did not increase when compared to the similar age group. MetS was thought to be related to age and gender predominance rather than the disease itself. Although mRSS was found to be significantly lower in patients with MetS, its sensitivity to predict MetS was found to be low. Nevertheless, our data suggest that the risk of MetS should be considered in SSc patients.

Keywords

SİSTEMİK SKLEROZ HASTALARINDA METABOLİK SENDROM SIKLIĞI

Öz

Amaç: Türk sistemik skleroz (SSc) hastalarında metabolik sendrom (MetS) prevalansının saptanması amaçlamıştır. Gereç ve Yöntem: Kesitsel ve tek merkezli çalışmaya, Temmuz-Eylül 2021 tarihleri arasında üçüncü basamak hastanemizin polikliniğinde başvuran 76 SSc olgusu alındı. MetS, National Cholesterol Education Program’s Adult Treatment Panel (NCEP-ATP III) kriterlerine göre tanımlandı. MetS’in SSc organ tutulumu ve hastalık özellikleri ile ilişkisi incelendi. Bulgular: ATP III kriterlerine göre MetS, 37 olguda (%48.7) saptandı. MetS sıklığının ilerleyen yaşla birlikte arttığı (40-45 yaşta: %25, 46-60 yaşta: %48.4, >60 yaşta: %62.9) görüldü. Olgular MetS olup olmamasına göre 2 gruba ayrılarak karşılaştırıldı. MetS olan olguların yaşlarının daha yüksek (58.2±9.4’e karşı 51.6±13.5, p=0.015) ve modifiye Rodnan deri skorlarının daha düşük olduğu görüldü. (14’e karşı 22, p=0,019). Hastalık tipi, süresi, aktivitesi, tutulan organlar/sistemler ve hastalık ilişkili hasar bakımından da grupların benzer nitelikte oldukları görüldü. Sonuç: Çalışmamızda SSc hastalarında saptanan Mets sıklığı ülkemiz genel popülasyonuna göre daha yüksek olsa da benzer yaş grubuna göre değerlendirildiğinde MetS sıklığının artmamış olduğu görülmektedir. MetS’in hastalığın kendisinden ziyade yaş ve cinsiyet baskınlığına bağlı olduğu düşünülmüştür. MetS'li hastalarda mRSS anlamlı olarak düşük saptanmasına rağmen, MetS'i öngörme duyarlılığı düşük bulunmuştur. Yine de verilerimiz SSc hastalarında MetS riskinin dikkate alınması gerektiğini ve daha geniş hasta gruplarında ileri çalışmalara ihtiyaç olduğunu ortaya koymaktadır.

Anahtar Kelimeler

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Details

Primary Language

English

Subjects

Internal Diseases , Rheumatology and Arthritis

Journal Section

Research Article

Authors

Ümit Özmen
0000-0002-2564-393X
Türkiye

Elif Er Gülbezer
0000-0003-4617-7760
Türkiye

Burcu Barutcuoğlu
0000-0001-6570-5229
Türkiye

Figen Yargucu Zihni ^*
0000-0001-7479-3582
Türkiye

Publication Date

September 9, 2024

Submission Date

August 14, 2024

Acceptance Date

August 16, 2024

Published in Issue

Year 2024 Volume: 63 Number: 3

DOI

https://doi.org/10.19161/etd.1532789

IZ

https://izlik.org/JA92MA98NM

Cite

RIS / Bibtex

Vancouver

1.Ümit Özmen, Elif Er Gülbezer, Burcu Barutcuoğlu, Figen Yargucu Zihni. Prevalence of metabolic syndrome patıents with systemic sclerosis. EJM. 2024 Sep. 1;63(3):474-83. doi:10.19161/etd.1532789