The relationship of pregnancy losses with frequently-used hematologic parameters

Atakan Turgutkaya; Ayşe Hilal Eroğlu Küçükdiler; Alper Seyhan; Ali Bolaman; Zehra Manav Yiğit; Gökay Bozkurt; İrfan Yavaşoğlu

doi:10.19161/etd.1549581

TR EN

Gebelik kayıplarının sık kullanılan hematolojik parametrelerle ilişkisi

Öz

Amaç: Tekrarlayan gebelik kaybı (TGK), hematoloji ve obstetrik alanında sık karşılaşılan ve endişe verici bir konudur; patogenezi belirsizdir. Bu çalışma, TGK ile potansiyel olarak ilişkili hematolojik faktörleri, özellikle trombofiliyi araştırmayı amaçlamaktadır. Gereç ve Yöntem: 2012-2024 yılları arasında en az bir gebelik kaybı yaşamış 170 kadın hastayı retrospektif olarak analiz ettik; antiphospholipid antikorları veya tanımlanabilir nedenleri olanlar dışlandı. Hastalar, bir veya iki düşük yapmış olanlar (grup A) ve ikiden fazla düşük yapmış olanlar (grup B) şeklinde iki gruba ayrıldı. Trombofili tarama testleri, hemogram ve koagülasyon parametrelerini değerlendirdik; analiz için SPSS 25.0 sürümü kullanıldı ve p < 0,05 değeri anlamlı kabul edildi. Bulgular: Dokuz hastanın (%5,3) bir, 71 hastanın (%41,8) iki, 60 hastanın (%35,3) üç, 21 hastanın (%12,4) dört, dört hastanın (%2.4) beş ve beş hastanın (%2.9) altı düşük öyküsü mevcuttu. Trombofili, protein C, S ve antitrombin seviyeleri açısından araştırılan genetik mutasyonlar ile her iki gruptaki gebelik kaybı sayısı arasında anlamlı bir fark bulunamadı. Hemogram parametreleri ve koagülasyon parametreleri arasında, her iki grup için aPTT dışında anlamlı bir fark yoktu. Grup B'nin aPTT değeri, grup A'nınkinden anlamlı derecede düşük bulundu (p = 0,04). Sonuç: TGK durumunda hematolojik parametrelerde çelişkili sonuçlar yaygındır ve homojen sonuçlar elde etmek kolay değildir. Kolay ve hızlı bir şekilde ölçülebilen düşük bir aPTT değeri, TGK'nın öngörülmesine yardımcı olabilecek bir parametre olabilir.

Anahtar Kelimeler

The relationship of pregnancy losses with frequently-used hematologic parameters

Abstract

Aim: Recurrent pregnancy loss (RPL) is a common and undesirable condition in hematology and obstetrics practice. Pathogenesis for most cases remains undetermined. Thrombophilia may be a potential factor for these patients. Here, we aimed to investigate hematological parameters that have the potential to contribute to or predict RPL and to present our data as a single-center experience. Materials and Methods: One hundred seventy female patients with at least one pregnancy loss between the years 2012 and 2024 were included retrospectively. The mean age of the patients was 34.48 ± 6.02. Patients with antiphospholipid antibodies and miscarriage due to an identifiable etiology (maternal anatomic and endocrine abnormalities, infectious causes, trauma, chromosomal abnormalities) were excluded from the study. Patients were divided into two groups, defined as patients with one or two miscarriages and more than two miscarriages, respectively. Thrombophilia screening tests (mutations and protein C/S/antithrombin levels), blood count and coagulation parameters were recorded and investigated whether there was a significant correlation in terms of miscarriage in the two groups. Results: Nine patients (5.3%), 71 patients (41.8%), 60 patients (35.3%), 21 patients (12.4%), four patients (2.4%), and five patients (2.9%) had a history of one, two, three, four, five, and six miscarriages, respectively. No significant difference was found between the genetic mutations investigated in terms of thrombophilia, protein C, S, and antithrombin levels, and the number of pregnancy losses in both groups. There was no significant difference between hemogram parameters and coagulation parameters except aPTT for both groups. The aPTT value of group B was found to be significantly lower than that of group A (p=0.04). Conclusion: Conflicting results in hematologic parameters in case of RPL are common and it is not easy to obtain homogeneous results. However, a low aPTT value, a parameter that can be easily and quickly measured, may be a parameter that can help predict RPL.

Keywords

Supporting Institution

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Ethical Statement

Ethical committee approval has been obtained (Aydın Adnan Menderes University Date: 20.11.2023-Number: 453317)

Thanks

Thanks to Dr Kübra Ecem Turgutkaya from Aydın Adnan Menderes University Public Health Department for making statistical analysis of the study.

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Details

Primary Language

English

Subjects

Clinical Sciences (Other) , Obstetrics and Gynaecology

Journal Section

Research Article

Authors

Atakan Turgutkaya ^*
0000-0001-8428-4730
Türkiye

Ayşe Hilal Eroğlu Küçükdiler
0000-0002-2604-3127
Türkiye

Alper Seyhan
0000-0003-0543-6180
Türkiye

Ali Bolaman
0000-0003-0651-5462
Türkiye

Zehra Manav Yiğit
0000-0002-9505-0371
Türkiye

Gökay Bozkurt
0000-0002-6963-3186
Türkiye

İrfan Yavaşoğlu
0000-0003-1703-2175
Türkiye

Publication Date

June 10, 2025

Submission Date

September 13, 2024

Acceptance Date

March 3, 2025

Published in Issue

Year 2025 Volume: 64 Number: 2

DOI

https://doi.org/10.19161/etd.1549581

IZ

https://izlik.org/JA96YL28FT

Cite

RIS / Bibtex

Vancouver

1.Atakan Turgutkaya, Ayşe Hilal Eroğlu Küçükdiler, Alper Seyhan, Ali Bolaman, Zehra Manav Yiğit, Gökay Bozkurt, İrfan Yavaşoğlu. The relationship of pregnancy losses with frequently-used hematologic parameters. EJM. 2025 Jun. 1;64(2):310-8. doi:10.19161/etd.1549581