Restless leg syndrome in multiple sclerosis: relationship with restless legs syndrome and fatigue, quality of life, daytime sleepiness, sleep quality and anxiety-depression

Asiye Tuba Özdoğar; Enes Aldemir; Pervin Yeşiloğlu; Vedat Çilingir

doi:10.19161/etd.1632949

TR EN

Multipl sklerozda huzursuz bacak sendromu: huzursuz bacak sendromu ile yorgunluk, yaşam kalitesi, gündüz uykululuğu, uyku kalitesi ve anksiyete-depresyon arasındaki ilişki

Öz

Amaç: Bu çalışma, multipl skleroz’lu (MS) bireylerde huzursuz bacaklar sendromu (HBS) şiddeti ile yorgunluk, yaşam kalitesi, gündüz uykululuk, uyku kalitesi, and anksiyete-depresyon seviyeleri arasındaki ilişkiyi incelemeyi amaçlamaktadır. Gereç ve Yöntem: Van Yüzüncü Yıl Üniversitesi MS kliniğinden toplam 73 MS'li birey çalışmaya dahil edildi. HBS tanısı, Uluslararası HBS Çalışma Grubu tarafından belirlenen kriterler esas alınarak konuldu. Uyku kalitesi, yorgunluk, gündüz uykululuğu, yaşam kalitesi, depresyon ve anksiyete düzeylerini değerlendirmek için Pittsburgh Uyku Kalitesi İndeksi (PUKİ), Modifiye Yorgunluk Etki Ölçeği (MYEÖ), Epworth Uykululuk Ölçeği (EUÖ), Tercihe Dayalı Multiple Skleroz İndeksi (TDMSİ) ve Hastane Anksiyete ve Depresyon Ölçeği (HADÖ) gibi çeşitli ölçekler kullanıldı. Bulgular: HBS, 20 katılımcıda (%27,40) tespit edildi. HBS'li ve HBS'siz MS'li bireyler arasında fiziksel, bilişsel ve toplam yorgunluk skorları ile uyku kalitesi değerlendirmesinin subjektif uyku kalitesi, uyku bozuklukları, gündüz işlev bozukluğu, uykuya dalma süresi, efektif uyku alışkanlığı alt skorları ve total PUKİ skoru açısından anlamlı farklılıklar bulundu (p<0,05). HBS şiddeti, MYEÖ-fiziksel (r=0.535), MYEÖ-toplam (r=0.494) ve PUKİ-toplam skorları ile orta derecede pozitif korelasyon gösterdi (r=0.492). Sonuç: Bu çalışma, HBS şiddeti ile uyku kalitesi, yorgunluk ve genel yaşam kalitesi arasındaki ilişkiler hakkında yeni bilgiler sunmaktadır.

Anahtar Kelimeler

Restless leg syndrome in multiple sclerosis: relationship with restless legs syndrome and fatigue, quality of life, daytime sleepiness, sleep quality and anxiety-depression

Abstract

Aim: This study aimed to explore the association between Restless Legs Syndrome (RLS) severity and fatigue, quality of life, daytime sleepiness, sleep quality, and levels of anxiety and depression in people with multiple sclerosis (MS, pwMS). Materials and Methods: A total of 73 pwMS were recruited from the MS clinic at Van Yüzüncü Yıl University. RLS was diagnosed based on the International RLS Study Group. Various scales were used to assess sleep quality, fatigue, daytime sleepiness, quality of life, and depression and anxiety, including the Pittsburgh Sleep Quality Index (PSQI), Modified Fatigue Impact Scale (MFIS), Epworth Sleepiness Scale (ESS), Preference-Based Multiple Sclerosis Index (PBMSI), and the Hospital Anxiety and Depression Scale (HADS). Results: RLS was identified in 20 participants (27.40%). Significant differences were observed between pwMS with and without RLS in terms of subjective sleep quality, sleep disturbances, daytime dysfunction, sleep latency and habitual sleep efficiency sub-scores of the PSQI, total PSQI score, physical, cognitive, and total fatigue scores (p<0.05). RLS severity showed a moderate positive correlation with MFIS-physical (r=0.535), MFIS-total (r=0.494), and PSQI-total scores (r=0.492). Conclusion: This study sheds light on the relationships between RLS severity and factors such as sleep quality and fatigue in pwMS.

Keywords

References

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Details

Primary Language

English

Subjects

Neurology and Neuromuscular Diseases

Journal Section

Research Article

Authors

Asiye Tuba Özdoğar ^*
0000-0003-0043-9374
Türkiye

Enes Aldemir
0000-0002-3850-5659
Türkiye

Pervin Yeşiloğlu
0009-0005-1409-4719
Türkiye

Vedat Çilingir
0000-0003-4635-2880
Türkiye

Publication Date

June 10, 2025

Submission Date

February 4, 2025

Acceptance Date

March 19, 2025

Published in Issue

Year 2025 Volume: 64 Number: 2

DOI

https://doi.org/10.19161/etd.1632949

IZ

https://izlik.org/JA56LG94UD

Cite

RIS / Bibtex

Vancouver

1.Asiye Tuba Özdoğar, Enes Aldemir, Pervin Yeşiloğlu, Vedat Çilingir. Restless leg syndrome in multiple sclerosis: relationship with restless legs syndrome and fatigue, quality of life, daytime sleepiness, sleep quality and anxiety-depression. EJM. 2025 Jun. 1;64(2):337-45. doi:10.19161/etd.1632949