MONOAMINE OXIDASE ACTIVITY AND NITRIC OXIDE LEVELS VARY BETWEEN DIFFERENT BRAIN REGIONS IN A GENDER SPECIFIC WAY

Volume: 44 Number: 3 September 1, 2005
  • Gülinnaz Alper
  • Eser Yıldırım Sözmen
  • Ferhan Girgin Sağın
  • İlknur Yanturalı
  • Lütfiye Kanıt
  • Biltan Ersöz
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MONOAMINE OXIDASE ACTIVITY AND NITRIC OXIDE LEVELS VARY BETWEEN DIFFERENT BRAIN REGIONS IN A GENDER SPECIFIC WAY

Abstract

The discovery of morphological sex differences in bird and mammal brains led to extensive research on the possible effects of sex steroids on different areas of the CNS. The aim of our study was to investigate MAO activity and NO levels in different brain regions in order to determine whether there are any significant differences between sexes. MAO activity was lowest in amygdala and highest in the cortex in both male (n=8) and female (n=8) Sprague-Dawley rats, while it was found to be higher in the female hippocampus. Hypothalamus had the highest total nitrite-nitrate levels and was followed by the amygdala. While nitrite levels were higher in females, nitrate and total nitrite-nitrate levels were similar in all brain regions in both sexes. In the female cerebellum a (-) correlation between MAO activity and nitrite levels could be noted. Current study is the first report providing evidence on sex related regional differences in brain NO levels with respect to MAO activity. These gender specific variations might be taken into consideration for further research studies underlying neurodegenerative disorders and therapeutic strategies using MAO inhibitors as well as sex steroids.

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Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Gülinnaz Alper

Eser Yıldırım Sözmen

Ferhan Girgin Sağın

İlknur Yanturalı

Lütfiye Kanıt

Biltan Ersöz

Publication Date

September 1, 2005

Submission Date

September 1, 2005

Acceptance Date

-

Published in Issue

Year 1970 Volume: 44 Number: 3

IZ

https://izlik.org/JA86CJ66CU

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Vancouver
1.Gülinnaz Alper, Eser Yıldırım Sözmen, Ferhan Girgin Sağın, İlknur Yanturalı, Lütfiye Kanıt, Biltan Ersöz. MONOAMİN OKSİDAZ AKTİVİTESİ VE NİTRİK OKSİT DÜZEYLERİ BEYNİN DEĞİŞİK BÖLGELERİNDE CİNSİYETLE İLİŞKİLİ DEĞİŞİM GÖSTERİR. EJM [Internet]. 2005 Sep. 1;44(3):139-43. Available from: https://izlik.org/JA86CJ66CU

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