The importance of serum markers to detect the activity of Sarcoidosis

Volume: 49 Number: 1 March 1, 2010
  • Arslan S
  • Çelik O
  • Baran A
  • Güngör S
  • Akkaya E
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The importance of serum markers to detect the activity of Sarcoidosis

Abstract

Aim: The aims of the present study were investigating the role of serum markers in estimating disease activity in sarcoidosis and determining the relationships between these markers. Material and Methods: The diagnosis of sarcoidosis was based on the clinical, radiological and hystopathological findings. The disease activity was determined according to the clinical and radiological findings and the results of pulmonary function tests. The levels of total ADA, ADA1, ADA2, ACE and IgE were determined in sera. The patients were divided into two groups according to the disease activity in year 1 and year 2. Results: There were no significant differences regarding mean serum levels of five markers between patients with active and inactive disease course. In patients with active disease course over last one year, there were significant correlations between serum levels of IgE-ADA1 and IgE-total ADA, ADA1-ADA2, and ADA1- total ADA. In patients with inactive disease course over last one year, there were significant correlations between serum levels of ADA1 - total ADA, ADA 2 - total ADA. Conclusion: Our findings suggest that there were no significant correlation between disease activity and serum levels of five markers in patients with sarcoidosis. However, our findings suggest that there are correlations between lymphocyte derived markers.

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Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Arslan S

Çelik O

Baran A

Güngör S

Akkaya E

Publication Date

March 1, 2010

Submission Date

March 1, 2010

Acceptance Date

-

Published in Issue

Year 2010 Volume: 49 Number: 1

IZ

https://izlik.org/JA32PC66LW

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Vancouver
1.Arslan S, Çelik O, Baran A, Güngör S, Akkaya E. Sarkoidoz’da aktivite belirlemede serum belirteçlerinin önemi. EJM [Internet]. 2010 Mar. 1;49(1):41-8. Available from: https://izlik.org/JA32PC66LW

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