Anterior segment and corneal biomechanics of achondroplasia patients
Abstract
Herein the anterior segment findings with Pentacam and corneal biomechanics with Ocular Response Analyser of 4 genetically proven cases of achondroplasia are reported. Four patients with heterozygous gain of function p.G380R mutation in fibroblast growth factor Receptor 3 (FGFR3) gene were evaluated. Central corneal thickness was higher than normal in both eyes of one patient, and corneal hysteresis and corneal resistance factor was lower in three eyes of two patients with accompanying high intraocular pressure readings. As a result, the affection of FGFR3 in achondroplasia patients might cause changes in central corneal thickness, corneal hysteresis and corneal resistance factor.
Keywords
References
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Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Case Report
Authors
Melis Palamar
*
0000-0002-2494-0131
Türkiye
Hüseyin Onay
0000-0002-0584-8866
Türkiye
Tahir Atik
0000-0002-1142-3872
Türkiye
Suzan Güven Yilmaz
0000-0001-8720-007X
Türkiye
Ferda Özkınay
0000-0001-7542-7787
Türkiye
Publication Date
June 1, 2018
Submission Date
April 3, 2017
Acceptance Date
May 8, 2017
Published in Issue
Year 2018 Volume: 57 Number: 2