Bone mineral density in obese children with prediabetes
Abstract
Aim: The aim of this study was to evaluate the relationships between bone mineral density (BMD) vs metabolic risk factors in obese adolescents with prediabetes.
Materials and Methods: A total of 131 obese children and adolescents, aged 6-18 years of age were enrolled the study. Prediabetes was determined by a fasting blood glucose level of ≥100 to 125 mg/dL or 2-hour oral glucose tolerance test value of ≥140 to 199 mg/dL. Five patients who were diagnosed as having type 2 diabetes were excluded and remaining participants were classified as normal glucose tolerance (NGT) and prediabetic. BMD was measured on calcaneus using quantitative ultrasound. BMD and metabolic parameters were investigated and compared in these two groups.
Results: There
was no significant difference in BMD between children and adolescents with
prediabetes (n = 37) or NGT (n = 89). The parameters of prediabetes did not
affect BMD and these results did not change when we adjusted for weight,
height, age, sex, pubertal status. The multivariate linear regression analysis
revealed that the only independent factor associated with higher BMD was higher
BMI (OR=0.007 95%CI 0.002-0.013 p=0.013). No significant associations were
found between BMD and waist circumference or biochemical measurements.
Conclusion: Plasma glucose within the
prediabetic range is not associated with bone mineral density in obese
children. Thus, the positive association of BMI with BMD may be by means of
alternative pathways.
Keywords
References
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Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Publication Date
June 1, 2018
Submission Date
February 23, 2017
Acceptance Date
April 21, 2017
Published in Issue
Year 2018 Volume: 57 Number: 2