Primary carcinoid tumor of the testis: A rare case
Abstract
Neuroendocrine tumors most commonly occur in the gastrointestinal tract, lungs and pancreas. Primary testicular neuroendocrine tumors are rare, constituting 0.23% of all testicular tumors. A 35-year-old man presented to urology department with a painless left scrotal mass. He had no history of trauma. Scrotal Doppler ultrasonography revealed a 2×1.5 cm, well-circumscribed, solid lesion. Tumor marker levels were normal and staging computed tomography demonstrated no evidence of metastasis. The patient subsequently underwent left radical orchiectomy. The orchiectomy material, grossly showed a 1.4x1.2 cm, well-circumscribed, yellow, solid mass. On histopathologic examination, primary testicular carcinoid tumors cannot be distinguished from well-differentiated neuroendocrine carcinoma. The diagnosis of a primary testicular carcinoid tumor was made after ruling out an extratesticular neuroendocrine tumor using clinical and radiological data. This rare case is presented with clinical, morphological and immunohistochemical features.
Keywords
References
- Langhans T. Ueber einen drusenpolyp im ileum. Virchows Arch 1867;38:559-60.
- Simon HB, McDonald JR, Culp OS. Argentaffin tumor (carcinoid) occurring in a benign cystic teratoma of the testicle. J Urol 1954;72(5):892-4.
- Lubana SS, Singh N, Chan HC, Heimann D. Primary neuroendocrine tumor (carcinoid tumor) of the testis: A case report with review of literature. Am J Case Rep 2015;31(16):328-32.
- Abbosh PH, Zhang S, Maclennan GT, et al. Germ cell origin of testicular carcinoid tumors. Clin Cancer Res 2008;14(5):1393-6.
- Mai K, Park P, Yazdi H, Carlier M. Leydig cell origin of testicular carcinoid tumor: immunohistochemical and electron microscopic evidence. Histopathology 2006;49(5):548-9.
- Davidoff MS, Schulze W, Middendorff R, Holstein AF. The Leydig cell of the human testis--a new member of the diffuse neuroendocrine system. Cell Tissue Res 1993;271(3):429-39.
- Rindi G, Klöppel G, Alhman H, et al. TNM staging of foregut (neuro)endocrine tumors: A consensus proposal including a grading system. Virchows Arch 2006;449(4):395-401.
- Bosman FT CF, Hruban RH, Theise ND. World Health Organization (WHO) Classification of Tumours of the Digestive System. 4th ed. Geneva; WHO Press; 2010:102-107.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Case Report
Authors
Gülruh Büberal
*
0000-0002-8241-1553
Türkiye
Banu Sarsik
0000-0003-4775-3942
Türkiye
Adnan Şimşir
0000-0002-0681-0325
Türkiye
Sadık Tamsel
0000-0001-8749-782X
Türkiye
Sait Şen
0000-0002-1100-6657
Türkiye
Publication Date
September 14, 2018
Submission Date
October 2, 2017
Acceptance Date
November 15, 2017
Published in Issue
Year 2018 Volume: 57 Number: 3