Diz osteoartritli hastalarda ortalama trombosit hacminin hastalık parametreleri ile ilişkisi

Neslihan Gökçen; İlke Coşkun Benlidayı; Sibel Başaran

doi:10.19161/etd.416648

TR EN

Diz osteoartritli hastalarda ortalama trombosit hacminin hastalık parametreleri ile ilişkisi

Öz

Amaç: Ortalama trombosit hacmi (mean platelet volume-MPV), platelet büyüklüğünü ve aktivitesi gösteren bir belirteçtir. MPV’nin, proinflamatuvar ve protrombik durumları yansıttığı bilinmektedir. Bazı çalışmalarda, MPV seviyelerinin, sinovitli hastalarda inflamasyon ve eritrosit sedimentasyon hızı (ESH) ile negatif ilişkili olduğu saptanmıştır. Bu bilgiler doğrultusunda, çalışmamızda dizde osteoartrit (OA) bulunan hastalarda MPV düzeyinin, radyolojik evre, klinik durum ve inflamatuvar belirteçler ile ilişkisinin araştırılması planlanmıştır.

Gereç ve Yöntem: Çalışmamıza Ocak 2016-Mart 2016 tarihleri arasında polikliniğimize başvuran ve diz OA tanısı ile takip edilen 160 hasta dahil edildi. Hastaların MPV, ESH ve C-reaktif protein (CRP) değerleri kaydedildi. Hastaların ağrı şiddetini ölçmek için vizüel anolog skala (VAS), fonksiyonel durumlarını değerlendirmek için Western Ontario ve McMaster Üniversiteleri Osteoartrit İndeksi (WOMAC) formu kullanıldı. Anteroposterior diz radyografilerinde Kellgren-Lawrence (KL) yöntemine göre radyolojik evreleme yapıldı.

Bulgular: MPV değeri ile ESH, CRP, total WOMAC skoru ve vizüel anolog skala (VAS) arasında korelasyon saptanmazken, MPV ile platelet sayımı negatif korele idi (r=-0.374). MPV seviyeleri, KL gruplarına (KL 1-4) göre analiz edildiğinde, gruplar arasında fark gözlenmedi (p=0.090). Hastalar hafif (KL 1-2) ve orta-ileri evre (KL 3-4) OA olarak değerlendirildiğinde, gruplar arasında MPV seviyeleri açısından anlamlı fark saptanmadı (p=0.066).

Sonuç: Diz OA’lı hastalarda, MPV seviyesi; radyolojik evreden bağımsız olup, klinik durum, ESH ve CRP düzeyleri ile de ilişkili bulunmamıştır. MPV’nin osteoartrit aktivitesindeki olası rolünün değerlendirilebilmesi için daha kapsamlı çalışmalara ihtiyaç vardır.

Anahtar Kelimeler

C-reaktif protein,eritrosit sedimentasyon hızı,osteoartrit,ortalama trombosit hacmi.

The association between mean platelet volume and disease parameters in knee osteoarthritis

Abstract

Aim: Mean platelet volume (MPV) is a marker that indicates platelet volume and activation as well as inflammatory conditions such as osteoarthritis with synovitis, rheumatoid arthritis and ankylosing spondylitis. The aim of the present study was to investigate the relationship between MPV level and the variables of physical examination, laboratory tests, and radiographic measurements in patients with knee osteoarthritis (OA).

Material and Methods: In this cross-sectional study, 160 patients with knee OA admitted to the Physical Medicine and Rehabilitation Department between January 2013 and November 2015 were included. MPV levels, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) of patients were obtained from electronic database of the hospital. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) was used to evaluate patients’ symptoms and disability. Also, patients’ pain was scored by visual analog scale (VAS). Knee OA was graded according to the Kellgren-Lawrence (KL) classification system on plain anteroposterior knee radiographs.

Results: No correlation was found between MPV and the parameters including ESR, CRP, visual analog scale score and WOMAC score. MPV was negatively correlated with platelet count (r=-0.374). When MPV level was analyzed with regard to the KL grades, no difference was found among groups (p=0.090). When patients were divided into two groups as mild OA (KL grade 1-2) and moderate-severe OA (KL grade 3-4), there was no difference between the groups in terms of MPV level (p=0.066).

Conclusion: No association was detected between MPV level and the parameters. Further studies are needed to evaluate the role of MPV level in disease activity among patients with knee osteoarthritis.

Keywords

C-reactive protein,erythrocyte sedimentation rate,osteoarthritis,mean platelet volume.

References

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Neslihan Gökçen ^*
0000-0003-3022-493X
Türkiye

İlke Coşkun Benlidayı
0000-0001-6517-5969
Türkiye

Sibel Başaran
0000-0003-3228-3909
Türkiye

Publication Date

September 14, 2018

Submission Date

July 24, 2017

Acceptance Date

September 12, 2017

Published in Issue

Year 1970 Volume: 57 Number: 3

DOI

https://doi.org/10.19161/etd.416648

IZ

https://izlik.org/JA33MR62XF

Cite

RIS / Bibtex

Vancouver

1.Neslihan Gökçen, İlke Coşkun Benlidayı, Sibel Başaran. Diz osteoartritli hastalarda ortalama trombosit hacminin hastalık parametreleri ile ilişkisi. EJM. 2018 Sep. 1;57(3):163-6. doi:10.19161/etd.416648