New therapy methods in osteoarthritis
Abstract
Osteoarthritis (OA) is the most common form of arthritis. Despite the many challenges presented by clinical trials in OA, improvements in our understanding of disease pathogenesis and a move to treat pain, as well as underlying disease process, mean there are now many new pharmacological therapies currently in various stages of clinical trials. Some challenges remain, but opportunities for improving symptoms and disease process in OA in the clinic with new pharmacological agents would appear to be on the close horizon
Keywords
References
- Watt FE, Gulati M. New Drug Treatments for Osteoarthritis: What is on the horizon? EMJ 2017;2: 50-8.
- Ondresik M, Maia FRA, Morais AS, et al. Management of knee osteoarthritis. Current status and future trends. Biotechnol Bioeng 2017;114:717-39.
- Cucchiarini M, Henrionnet C, Mainard D, et al. New trends in articular cartilage repair. J Exp Orthop 2015; 2:8. DOI 10.1186/s40634-015-0026-0
- Mobasheri A. The Future of Osteoarthritis Therapeutics: Targeted Pharmacological Therapy. Curr Rheumatol Rep 2013;15:364. doi: 10.1007/s11926-013-0385-4.
- Smith SR, Deshpande BR, Collins JE, Katz JN, Losina E. Comparative pain reduction of oral non-steroidal anti-inflammatory drugs and opioids for knee osteoarthritis: systematic analytic review. Osteoarthritis Cartilage 2016;24(6):962-72.
- Bingham CO, Buckland-Wright JC, Garnero P, et al. Risedronate decreases biochemical markers of cartilage degradation but does not decrease symptoms or slow radiographic progression in patients with medial compartment osteoarthritis of the knee: results of the two-year multinational knee osteoarthritis structural arthritis study. Arthritis Rheum 2006;54(11):3494-507.
- Rossini M, Adami S, Fracassi E, et al. Effects of intra- articular clodronate in the treatment of knee osteoarthritis: results of a double- blind, randomized placebo-controlled trial. Rheumatol Int 2015;35(2):255-63.
- Laslett LL, Kingsbury SR, Hensor EM, Bowes MA, Conaghan PG. Effect of bisphosphonate use in patients with symptomatic and radiographic knee osteoarthritis: data from the Osteoarthritis Initiative. Ann Rheum Dis 2014;73(5):824-30.
Details
Primary Language
Turkish
Subjects
-
Journal Section
Other
Publication Date
October 25, 2019
Submission Date
October 19, 2018
Acceptance Date
August 15, 2019
Published in Issue
Year 1970