Factors affecting survival in liver metastasis of colorectal cancer

Osman Bozbıyık; Ahmet Çoker

doi:10.19161/etd.1036904

TR EN

Kolorektal kanserin karaciğer metastazında sağ kalımı etkileyen faktörler

Abstract

Amaç: Kolorektal kanser en sık görülen malignitelerden biridir ve hastaların %50’sinde karaciğer metastazı gelişir. Kolorektal kanserlerin karaciğer metastazlarında hepatik rezeksiyon en etkili tedavi yöntemidir. Bu çalışmanın amacı kolorektal kanserlerin karaciğer metastazında hepatik rezeksiyon uygulanan hastalarda sağ kalımı etkileyen faktörlerin ortaya konmasıdır. Gereç ve Yöntem: Ege Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı’nda kolorektal kanserin karaciğer metastazı nedeniyle hepatik rezeksiyon uygulanmış olan hastaların verileri retrospektif olarak incelendi. Hastaların takip dosyaları incelenerek sağ kalım verileri elde edildi. Hastalara ait faktörlerin sağ kalıma etkisi değerlendirildi. Bulgular: Çalışmaya dâhil edilen 62 hastanın yaş ortalaması 58,08±10,92 idi. Genel sağ kalım ortalaması 50,4 ay (CI: 41,2-59,7) olarak saptandı. Hasta yaşının 65’ten büyük olması (<65 yıl:56,4±5,5 ay / ≥65 yıl:29,3±4,8 ay, p=0,007), primer tümörde dörtten fazla lenf nodu metastazı olması (N0:56,1±7,9 ay/ N1:56,5±6,5 ay/ N2:18,0±3,0, p=0,001), bilober karaciğer metastazı varlığı (Unilober: 53,4±5,0 ay/ bilober: 24,0±4,4 ay, p=0,026) ve karaciğer rezeksiyon sınırının 2 mm’den yakın olması (<2 mm: 28,4±7,7 ay/ 2-9 mm:61,1±7,6ay, ≥10mm: 46,3±5,9ay, p=0,003) istatistiksel olarak anlamlı şekilde sağ kalımı azaltan faktörler olarak saptandı. Cinsiyet, primer tümörün yerleşimi, primer tümörün invazyon derinliği, kolorektal ve karaciğer cerrahisi arasındaki süre, karsinoembriyonik antijen düzeyi, metastazın çapı, metastaz sayısı ve cerrahi rezeksiyonun genişliği ile sağ kalım süresi arasında istatiksel olarak anlamlı fark saptanmadı Sonuç: Kolorektal kanserin karaciğer metastazına yönelik cerrahi rezeksiyon uygulanan hastalarda, 65 yaşından büyük olmak, kolon rezeksiyon materyalinde dörtten fazla lenf nodu olması, bilober karaciğer metastazı ve cerrahi sınırın 2 mm’den yakın olması kötü prognostik faktörlerdir.

Keywords

Factors affecting survival in liver metastasis of colorectal cancer

Abstract

Aim: Colorectal cancer is among the most common malignancies and liver metastasis is developed in 50% of the patients. Hepatic resection is the most effective treatment in liver metastasis of colorectal cancer. The present study aimed to determine the factors that affect survival in patients who underwent hepatic resection in liver metastasis of colorectal cancer. Materials and Methods: The data on patients who underwent hepatic resection due to liver metastasis of colorectal cancer in Ege University, Faculty of Medicine, General Surgery Department were retrospectively analyzed. Survival data were collected with the review of patient follow-up files. The effects of the factors pertaining to the patients on survival were determined. Results: The mean age of the 62 participating patients was 58.08 ± 10.92 years. Total survival rate was 50.4 months (CI: 41.2-59.7). The factors that statistically significantly reduced the survival rate were determined as follows: Patient age> 65 (<65 years: 56.4 ± 5.5 months / ≥65 years: 29.3 ± 4.8 months, p = 0.007), presence of more than four lymph node metastases in the primary tumor (N0: 56.1 ± 7.9 months / N1: 56.5 ± 6.5 months / N2: 18.0 ± 3.0, p = 0.001), presence of bilobular liver metastasis (Uni-lobular: 53.4 ± 5.0 months / bilobular: 24.0 ± 4.4 months, p = 0.026), and liver resection margin closer than 2 mm (<2 mm: 28.4 ± 7.7 months / 2-9 mm: 61.1 ± 7 , 6 months, ≥10mm: 46.3 ± 5.9 months, p = 0.003). No statistically significant differences were determined in survival based on gender, location of the primary tumor, the invasion depth of the primary tumor, the time between colorectal and liver surgery, the carcinoembryonic antigen level, the metastasis diameter, the number of metastases and the extent of surgical resection. Conclusion: In patients who underwent surgical resection for liver metastasis of colorectal cancer, age older than sixty-five years, the presence of more than four lymph nodes in the colon resection material, bilobular liver metastasis, and a surgical margin closer than 2 mm were poor prognostic factors.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Osman Bozbıyık ^*
0000-0002-1827-2720
Türkiye

Ahmet Çoker
0000-0002-5573-7216
Türkiye

Publication Date

December 22, 2021

Submission Date

January 14, 2021

Acceptance Date

February 19, 2021

Published in Issue

Year 2021 Volume: 60 Number: 4

DOI

https://doi.org/10.19161/etd.1036904

IZ

https://izlik.org/JA95CF88LY

Cite

RIS / Bibtex

APA

Bozbıyık, O., & Çoker, A. (2021). Factors affecting survival in liver metastasis of colorectal cancer. Ege Tıp Dergisi, 60(4), 305-313. https://doi.org/10.19161/etd.1036904

AMA

1.Bozbıyık O, Çoker A. Factors affecting survival in liver metastasis of colorectal cancer. EJM. 2021;60(4):305-313. doi:10.19161/etd.1036904

Chicago

Bozbıyık, Osman, and Ahmet Çoker. 2021. “Factors Affecting Survival in Liver Metastasis of Colorectal Cancer”. Ege Tıp Dergisi 60 (4): 305-13. https://doi.org/10.19161/etd.1036904.

EndNote

Bozbıyık O, Çoker A (December 1, 2021) Factors affecting survival in liver metastasis of colorectal cancer. Ege Tıp Dergisi 60 4 305–313.

IEEE

[1]O. Bozbıyık and A. Çoker, “Factors affecting survival in liver metastasis of colorectal cancer”, EJM, vol. 60, no. 4, pp. 305–313, Dec. 2021, doi: 10.19161/etd.1036904.

ISNAD

Bozbıyık, Osman - Çoker, Ahmet. “Factors Affecting Survival in Liver Metastasis of Colorectal Cancer”. Ege Tıp Dergisi 60/4 (December 1, 2021): 305-313. https://doi.org/10.19161/etd.1036904.

JAMA

1.Bozbıyık O, Çoker A. Factors affecting survival in liver metastasis of colorectal cancer. EJM. 2021;60:305–313.

MLA

Bozbıyık, Osman, and Ahmet Çoker. “Factors Affecting Survival in Liver Metastasis of Colorectal Cancer”. Ege Tıp Dergisi, vol. 60, no. 4, Dec. 2021, pp. 305-13, doi:10.19161/etd.1036904.

Vancouver

1.Osman Bozbıyık, Ahmet Çoker. Factors affecting survival in liver metastasis of colorectal cancer. EJM. 2021 Dec. 1;60(4):305-13. doi:10.19161/etd.1036904