Case Report
BibTex RIS Cite

Uzun süreli proton pompa inhibitörü kullanımına sekonder gastrik nöroendokrin hiperplazi

Year 2018, , 244 - 246, 03.12.2018
https://doi.org/10.19161/etd.416055

Abstract

Yaşla
birlikte epigastrik şikâyetler daha yaygın görülmekte ve bu nedenle proton
pompası inhibitörlerine (PPİ) yaşlılarda daha sık başvurulmaktadır. PPİ
tedavisi, zararsız olduğu yönündeki algı nedeniyle uygunsuz doz ve sürede
kullanılmaktadır. Uzun süre PPI kullanımına bağlı ortaya çıkan sık yan etkiler;
enfeksiyonlar (Clostridium difficile
enteriti, mikroskobik kolit, toplum kaynaklı pnömoni), sindirim ve emilim
bozuklukları (vitamin B12, demir, kalsiyum eksiklikleri, hipofosfatemi,
hipomagnezemi), kemik kırıkları, akut interstisyel nefrit, demans, kronik
böbrek yetmezliğidir. Bu olguda kronik PPİ kullanımının nadir görülen yan
etkilerinden biri olan nöroendokrin tümör sunularak uygunsuz ilaç kullanımının
sonuçlarına dikkat çekilmek istenmiştir.

References

  • Thompson W, Black C, Welch V, Farrell B, Bjerre LM, Tugwell P. Patient values and preferences surrounding proton pump inhibitor use: A scoping review. Patient 2018;11(1):17-28.
  • Cavalcoli F, Zilli A, Conte D, Ciafardini C, Massironi S. Gastric neuroendocrine neoplasms and proton pump inhibitors: Fact or coincidence? Scand J Gastroenterol 2015;50(11):1397-403.
  • Uygun A. Uzun süre proton pompa inhibitörleri (PPI) kullanılacaksa, hangi PPI tercih edilmelidir? Nelere dikkat edilmelidir? Güncel Gastroenterol 2013;17(1):46-58.
  • O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2. Age Ageing 2015;44(2):213-8.
  • Lundell L, Vieth M, Gibson F, Nagy P, Kahrilas PJ. Systematic review: The effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment Pharmacol Ther 2015;42(6):649-63.
  • Nandy N, Hanson JA, Strickland RG, McCarthy DM. Solitary gastric carcinoid tumor associated with long-term use of omeprazole: A case report and review of the literature. Dig Dis Sci 2016;61(3):708-12.
  • Chan EW, Lau WC, Leung WK, et al. Prevention of dabigatran-related gastrointestinal bleeding with gastroprotective agents: A population-based study. Gastroenterology 2015;149(3):586-95.
  • Sherwood MW, Nessel CC, Hellkamp AS, et al. Gastrointestinal bleeding in patients with atrial fibrillation treated with rivaroxaban or warfarin: ROCKET AF trial. J Am Coll Cardiol 2015;66(21):2271-81.
  • İnce AT, Tosun S. Gastroenteropankreatik nöroendokrin tümörler. Güncel Gastroenterol 2005;9(3):105-14.

Neuroendocrine hyperplasia caused by long term use of proton pump inhibitors

Year 2018, , 244 - 246, 03.12.2018
https://doi.org/10.19161/etd.416055

Abstract

Abdominal
complaints are more common in elderly, therefore the use of proton pump
inhibitors (PPI) has increased in the aging population. PPI is prescribed
inappropriately, as PPIs have long been perceived relatively harmless. Advers
risks associated with chronic use of PPI; infections (Clostridium difficile
enteritis, microscopic colitis, community-acquired pneumonia), digestive and
absorption disorders (vitamin B12, iron, calcium deficiencies,
hypophosphatemia, hypomagnesemia), bone fractures, acute interstitial
nephritis, dementia, chronic renal disease. In this case, neuroendocrine tumor,
which is one of the rare side effects of chronic PPI use, is presented to
derive the attention of health professionals, to the impact of inappropriate
drug use.

References

  • Thompson W, Black C, Welch V, Farrell B, Bjerre LM, Tugwell P. Patient values and preferences surrounding proton pump inhibitor use: A scoping review. Patient 2018;11(1):17-28.
  • Cavalcoli F, Zilli A, Conte D, Ciafardini C, Massironi S. Gastric neuroendocrine neoplasms and proton pump inhibitors: Fact or coincidence? Scand J Gastroenterol 2015;50(11):1397-403.
  • Uygun A. Uzun süre proton pompa inhibitörleri (PPI) kullanılacaksa, hangi PPI tercih edilmelidir? Nelere dikkat edilmelidir? Güncel Gastroenterol 2013;17(1):46-58.
  • O'Mahony D, O'Sullivan D, Byrne S, O'Connor MN, Ryan C, Gallagher P. STOPP/START criteria for potentially inappropriate prescribing in older people: Version 2. Age Ageing 2015;44(2):213-8.
  • Lundell L, Vieth M, Gibson F, Nagy P, Kahrilas PJ. Systematic review: The effects of long-term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment Pharmacol Ther 2015;42(6):649-63.
  • Nandy N, Hanson JA, Strickland RG, McCarthy DM. Solitary gastric carcinoid tumor associated with long-term use of omeprazole: A case report and review of the literature. Dig Dis Sci 2016;61(3):708-12.
  • Chan EW, Lau WC, Leung WK, et al. Prevention of dabigatran-related gastrointestinal bleeding with gastroprotective agents: A population-based study. Gastroenterology 2015;149(3):586-95.
  • Sherwood MW, Nessel CC, Hellkamp AS, et al. Gastrointestinal bleeding in patients with atrial fibrillation treated with rivaroxaban or warfarin: ROCKET AF trial. J Am Coll Cardiol 2015;66(21):2271-81.
  • İnce AT, Tosun S. Gastroenteropankreatik nöroendokrin tümörler. Güncel Gastroenterol 2005;9(3):105-14.
There are 9 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Case Reports
Authors

Fatma Özge Kayhan Koçak 0000-0002-6447-2352

Sercan Sahutoğlu 0000-0002-9217-5945

Bahattin Gokdemir 0000-0001-9748-6913

Zeliha Fulden Saraç 0000-0001-9281-2492

Sevnaz Şahin 0000-0001-5457-901X

Selahattin Fehmi Akçiçek 0000-0003-2583-4709

Publication Date December 3, 2018
Submission Date September 5, 2017
Published in Issue Year 2018

Cite

Vancouver Kayhan Koçak FÖ, Sahutoğlu S, Gokdemir B, Saraç ZF, Şahin S, Akçiçek SF. Uzun süreli proton pompa inhibitörü kullanımına sekonder gastrik nöroendokrin hiperplazi. ETD. 2018;57(4):244-6.

Cited By

Proton Pompa İnhibitörlerinin Kırık Oluşumuna Etkisi ve Bakıma Yansıması
Dokuz Eylül Üniversitesi Hemşirelik Fakültesi Elektronik Dergisi
Seda AKUTAY
https://doi.org/10.46483/deuhfed.736337

1724617243172472652917240      26515    

 26507    26508 26517265142651826513

2652026519