Case Report
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Teicoplanin induced seizure

Year 2017, Volume: 56 Issue: 4, 214 - 215, 01.12.2017

Bayram Yeşil Mustafa Kaplan Orhan Coşkun Volkan Gökbulut Ferhat Bacaksız Erkin Öztaş Ertuğrul Kayaçetin

https://doi.org/10.19161/etd.399650

Abstract

Fifty six years old male patient admitted to our clinic with cholangitis due to anastomosis stricture after liver transplantation. Percutaneous transhepatic cholangiography (PTK) was performed and imipenem was started. Teicoplanin was added to treatment at 10th day because of fewer and elevated WBC. Tonic clonic epileptic seizures was developed 1 day after the teicoplanin was started. Cranial CT, MRI and EEG is performed. Only chronic ischemic changes was seen in MRI. At laboratory analysis, serum sodium level was 124 mEq/L and was corrected. Levetiracetam was started. The patient was entubated because of metabolic asidosis due to repeated epileptic seizures. Because of seizures started after teikoplanin and that we could not find any etiologic factor, we thought that seizure was induced by teicoplain. The drug was stopped and seizures ended. But the patient died due to ventilator associated pneumonia. Teicoplanin induced seizure must be kept in mind in infected patients with seizures.

Keywords

Epilepsy meticilline resistant staphylococcus aureus (MRSA) teicoplanin

References

  • Takechi K, Fujiwara A, Watanabe Y, Kamei C. Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice. Epilepsy Rres 2009;84(2-3):127-34.
  • Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci 2008;107(4):428-33.
  • Rahman MA, Ago J, Matsumoto N, Ishikawa T, Kamei C. Epileptogenic activity of methicillin-resistant Staphylococcus aureus (MRSA) antibiotics in rats. Bio and Pharm Bul 2006;29(10):2035-40.
  • Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: A practical clinical definition of epilepsy. Epilepsia 2014;55(4):475-82.
  • Beghi E, Carpio A, Forsgren L, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010;51(4):671-5.
  • Pesola GR, Avasarala J. Bupropion seizure proportion among new-onset generalized seizures and drug related seizures presenting to an emergency department. J Emerg Med 2002;22(3):235-9.

Teikoplaninin indüklediği nöbet

Year 2017, Volume: 56 Issue: 4, 214 - 215, 01.12.2017

Bayram Yeşil Mustafa Kaplan Orhan Coşkun Volkan Gökbulut Ferhat Bacaksız Erkin Öztaş Ertuğrul Kayaçetin

https://doi.org/10.19161/etd.399650

Abstract

Elli altı yaşında erkek hasta karaciğer nakli sonrası anastomoz darlığı ve kolanjit tanısı ile kliniğimize başvurdu. Hastaya perkütan transhepatik kolanjiografi (PTK) yapıldı. Kolanjit tanısı ile imipenem başlandı. Ancak ateş ve beyaz küre değerinde yükseklik olması üzerine imipenem tedavisinin 10. gününde teikoplanin eklendi. İlaç başlandıktan bir gün sonra tonik klonik epileptik nöbetleri oldu. Kranial bilgisayarlı tomografi (BT), elektroensefalografi (EEG) ve kranial magnetik rezonans görüntüleme (MRG) çekildi. Sadece MRG’de kronik iskemik değişiklikler saptandı. Laboratuvar analizinde kan sodyum 124 mEq/L saptanan hastaya replasman tedavisi yapıldı. Hastaya levetiracetam başlandı. Epileptik atakları tekrarlayan hastada metabolik asidoz gelişti ve entübe edildi. Teikoplanin verilmesinden hemen sonra başlaması ve diğer etiyolojik faktörlerin dışlanması nedeniyle nöbetlerin teikoplanine bağlı olabileceği düşünüldü ve hastanın ilacı kesildi. İlaç kesilmesi sonrası nöbetler kesildi. Ancak ventilatöre bağlı pnömoni gelişen hasta exitus oldu. Enfekte ve teikoplanin alan bir hastada nöbet varlığında ilaca bağlı nöbet akılda tutulmalıdır.

Keywords

Epilepsi metisilin dirençli staphylococcus aureus (MRSA) teikoplanin

References

  • Takechi K, Fujiwara A, Watanabe Y, Kamei C. Participation of GABA-ergic system in epileptogenic activity induced by teicoplanin in mice. Epilepsy Rres 2009;84(2-3):127-34.
  • Takechi K, Ishikawa T, Kamei C. Epileptogenic activity induced by teicoplanin and effects of some antiepileptics in mice. J Pharmacol Sci 2008;107(4):428-33.
  • Rahman MA, Ago J, Matsumoto N, Ishikawa T, Kamei C. Epileptogenic activity of methicillin-resistant Staphylococcus aureus (MRSA) antibiotics in rats. Bio and Pharm Bul 2006;29(10):2035-40.
  • Fisher RS, Acevedo C, Arzimanoglou A, et al. ILAE official report: A practical clinical definition of epilepsy. Epilepsia 2014;55(4):475-82.
  • Beghi E, Carpio A, Forsgren L, et al. Recommendation for a definition of acute symptomatic seizure. Epilepsia 2010;51(4):671-5.
  • Pesola GR, Avasarala J. Bupropion seizure proportion among new-onset generalized seizures and drug related seizures presenting to an emergency department. J Emerg Med 2002;22(3):235-9.
There are 6 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Case Reports
Authors

Bayram Yeşil 0000-0002-9511-6836

Mustafa Kaplan 0000-0002-6959-675X

Orhan Coşkun 0000-0002-3124-9517

Volkan Gökbulut 0000-0002-7906-2479

Ferhat Bacaksız 0000-0002-9670-3290

Erkin Öztaş 0000-0002-3160-7492

Ertuğrul Kayaçetin 0000-0002-8822-3991

Publication Date December 1, 2017
Submission Date January 16, 2017
Published in Issue Year 2017Volume: 56 Issue: 4

Cite

Vancouver Yeşil B, Kaplan M, Coşkun O, Gökbulut V, Bacaksız F, Öztaş E, Kayaçetin E. Teikoplaninin indüklediği nöbet. EJM. 2017;56(4):214-5.
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