Year 2018, Volume 57 , Issue 1, Pages 8 - 13 2018-03-01

Akut böbrek hasarlanmasında yeni bir gösterge: Nötrofil-lenfosit oranı
A novel predictor in acute kidney injury: Neutrophil to lymphocyte count

Devrim BOZKURT [1] , Aslı KILAVUZ [2] , Mehmet BERKTAŞ [3] , Fehmi AKÇİÇEK [4]


Amaç: Akut böbrek hasarlanması (ABH), sistemik inflamasyonu yansıtan bir klinik durumdur. Nötrofil-lenfosit oranı (NLO), değişik inflamatuar durumlarda bilinen yeni prognostik göstergedir. Bu retrospektif kohort çalışmasında iki yüz on üç akut böbrek hasarlanmalı hasta incelendi.

Gereç ve Yöntem: Hastaların başvuru anı, çıkış anı ve taburculuk sonrası poliklinik takiplerinde var olan altı ay bir yıllık değerleri kaydedildi. Bu takip periyodunda hastaların NLO değişimleri incelendi.

Bulgular: Tek değişkenli ve çoklu değişkenli regresyon analizlerinde, hem taburculuk anı NLO değeri hem de zamansal NLO değişimi, akut böbrek hasarlanmalı hastalarda bağımsız mortalite öngörücüsü olarak saptandı. Yapılan ROC analizinde, mortalite ön görücülüğünde, NLO üst sınır için 9.90 değeri, %87 özgüllük ve %73 duyarlılıkta saptandı (HR: 7.31, CI 3.36-15.91; p<0.001).

Sonuç: Akut böbrek hasarlanmalı hastalarda, NLO, hastane yatış sürecinde mortalite için yeni bir takip parametresi olabilir.


Aim: Acute Kidney injury (AKI) represents a clinical condition reflecting systemic inflammation. Neutrophil-to-lymphocyte ratio (NLR) is novel prognostic marker in various inflammatory conditions. In this retrospective cohort we evaluated two hundred and thirteen AKI patients.

Materials and Methods: The patients’ baseline values on admission, final values at discharge and after discharging during follow-up period in outpatient clinic until six months to one year were recorded. NLR change during follow-up period after hospitalization was also examined.

Results: It has been shown that, final NLR and timely changed NLR during hospital course are significant mortality predictors in AKI patients both in univariate and mutually adjusted multivariate logistic regression analysis. To predict mortality, we showed that, level of 9.90 point for final NLR has 73% sensitivity and 87% specifity as compared to value below in ROC analysis (HR: 7.31, CI 3.36-15.91; p<0.001).

Conclusion: NLR may be a novel screening tool on patiens' mortality for AKI patients during their hospital course.

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Primary Language en
Journal Section Research Articles
Authors

Orcid: 0000-0003-4557-3390
Author: Devrim BOZKURT (Primary Author)
Institution: EGE ÜNİVERSİTESİ, TIP FAKÜLTESİ, DAHİLİ TIP BİLİMLERİ BÖLÜMÜ, GÖĞÜS HASTALIKLARI ANABİLİM DALI, YOĞUN BAKIM BİLİM DALI
Country: Turkey


Orcid: 0000-0002-0474-9911
Author: Aslı KILAVUZ
Institution: Ege University Faculty of Medicine, Department of Internal Medicine, Intensive Care Unit, İzmir
Country: Turkey


Orcid: 0000-0003-0604-9449
Author: Mehmet BERKTAŞ
Institution: YEDİTEPE ÜNİVERSİTESİ, TIP FAKÜLTESİ, TEMEL TIP BİLİMLERİ BÖLÜMÜ, BİYOİSTATİSTİK VE TIP BİLİŞİMİ ANABİLİM DALI
Country: Turkey


Orcid: 0000-0003-2583-4709
Author: Fehmi AKÇİÇEK
Institution: Ege University Faculty of Medicine, Department of Internal Medicine, Intensive Care Unit, İzmir
Country: Turkey


Dates

Application Date : August 21, 2016
Acceptance Date : December 16, 2016
Publication Date : March 1, 2018

Bibtex @research article { etd414355, journal = {Ege Tıp Dergisi}, issn = {1016-9113}, eissn = {2147-6500}, address = {}, publisher = {Ege University}, year = {2018}, volume = {57}, pages = {8 - 13}, doi = {10.19161/etd.414355}, title = {A novel predictor in acute kidney injury: Neutrophil to lymphocyte count}, key = {cite}, author = {Bozkurt, Devrim and Kılavuz, Aslı and Berktaş, Mehmet and Akçiçek, Fehmi} }
APA Bozkurt, D , Kılavuz, A , Berktaş, M , Akçiçek, F . (2018). A novel predictor in acute kidney injury: Neutrophil to lymphocyte count . Ege Tıp Dergisi , 57 (1) , 8-13 . DOI: 10.19161/etd.414355
MLA Bozkurt, D , Kılavuz, A , Berktaş, M , Akçiçek, F . "A novel predictor in acute kidney injury: Neutrophil to lymphocyte count" . Ege Tıp Dergisi 57 (2018 ): 8-13 <http://egetipdergisi.com.tr/en/pub/issue/36515/414355>
Chicago Bozkurt, D , Kılavuz, A , Berktaş, M , Akçiçek, F . "A novel predictor in acute kidney injury: Neutrophil to lymphocyte count". Ege Tıp Dergisi 57 (2018 ): 8-13
RIS TY - JOUR T1 - A novel predictor in acute kidney injury: Neutrophil to lymphocyte count AU - Devrim Bozkurt , Aslı Kılavuz , Mehmet Berktaş , Fehmi Akçiçek Y1 - 2018 PY - 2018 N1 - doi: 10.19161/etd.414355 DO - 10.19161/etd.414355 T2 - Ege Tıp Dergisi JF - Journal JO - JOR SP - 8 EP - 13 VL - 57 IS - 1 SN - 1016-9113-2147-6500 M3 - doi: 10.19161/etd.414355 UR - https://doi.org/10.19161/etd.414355 Y2 - 2016 ER -
EndNote %0 Ege Tıp Dergisi A novel predictor in acute kidney injury: Neutrophil to lymphocyte count %A Devrim Bozkurt , Aslı Kılavuz , Mehmet Berktaş , Fehmi Akçiçek %T A novel predictor in acute kidney injury: Neutrophil to lymphocyte count %D 2018 %J Ege Tıp Dergisi %P 1016-9113-2147-6500 %V 57 %N 1 %R doi: 10.19161/etd.414355 %U 10.19161/etd.414355
ISNAD Bozkurt, Devrim , Kılavuz, Aslı , Berktaş, Mehmet , Akçiçek, Fehmi . "A novel predictor in acute kidney injury: Neutrophil to lymphocyte count". Ege Tıp Dergisi 57 / 1 (March 2018): 8-13 . https://doi.org/10.19161/etd.414355
AMA Bozkurt D , Kılavuz A , Berktaş M , Akçiçek F . A novel predictor in acute kidney injury: Neutrophil to lymphocyte count. ETD. 2018; 57(1): 8-13.
Vancouver Bozkurt D , Kılavuz A , Berktaş M , Akçiçek F . A novel predictor in acute kidney injury: Neutrophil to lymphocyte count. Ege Tıp Dergisi. 2018; 57(1): 8-13.
IEEE D. Bozkurt , A. Kılavuz , M. Berktaş and F. Akçiçek , "A novel predictor in acute kidney injury: Neutrophil to lymphocyte count", Ege Tıp Dergisi, vol. 57, no. 1, pp. 8-13, Mar. 2018, doi:10.19161/etd.414355