Abstract
Aim: Inflammatory benign lesions are the most common lesions of the nasal cavity and paranasal sinuses, while malignant lesions very rare. In this study, we aimed to review the frequency and distribution of lesions in the nasal cavity and paranasal sinuses with the literature.
Materials and Methods: Histopathological diagnosis and localization of lesions in nasal cavity and paranasal sinuses of 447 cases reported in our pathology unit between 2013 and 2018 were examined retrospectively in the Pathology Department of Kütahya Health Sciences University, Evliya Çelebi Education and Research Hospital.
Results: A total of 447 cases, 295 (65.99%) males and 152 (34.01%) females were included in the study (M/F = 1.94). The mean age of the cases included in the study was 43.54. Histopathologically, 6 (1.35) lesions were malignant and 441 (%98.65) were benign. Nasal polyps were the majority of the lesions (82.78%; 370 lesions). The other benign lesions: 30 (%6.72) sinonasal papilloma (24 inverted papilloma, 6 exophytic papilloma), 16 (%3.58) pyogenic granuloma, 11 (%2.46) mucocele, 3 (%0.68) fibroma, 2 (%0.45) nasoalveolar cyst, 1 (%0.22) giant epidermoid cyst, 1 (%0.22) hemangiopericytoma, 1 (%0.22) hemangioendothelioma, 1 (%0.22) angioleiomyoma, 1 (%0.22) respiratory epithelial adenomatoid hamartoma, 1 (%0.22) osteoma, 1 (%0.22) fibrous dysplasia, 1 (%0.22) fibroepithelial polyp and 1 (%0.22) hyperkeratotic actinic keratosis. Malignant lesions; 3 (%0.68) malignant melanoma, 2 (%0.45) squamous cell carcinoma and 1 (%0.22) adenoid cystic carcinoma were detected. Conclusion: Sinonasal lesions can be differentiated benign and malignant according to the histopathological examination. The lesions in this region are mostly benign and most of the lesions are nasal polyps. Sinonasal region malignancies are aggressive tumors, they are rarely seen.
References
- Ogle OE, Weinstock RJ, Friedman E. Surgical anatomy of the nasal cavity and paranasal sinuses. Oral Maxillofac Surg Clin North Am 2012; 24: 155-66.
- Rosai J. Nasal cavity, paranasal sinuses and nasopharnyx. In: Rosai J (ed) Rosai and Ackerman's Surgical pathology. Vol 1, 10th Philadelphia; Mosby Elsevier; 2011: 291-306.
- Slootweg PJ, Chan JKC, Stelow EB, Thompson LDR. Tumors of the nasal cavity, paranasal sinuses and skull base. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (ed) WHO Classification of tumors, Pathology and Genetics of Head and Neck Tumors. Vol 9, 4rd ed. Lyon: IARC Press. 2017: 11-61.
- Kaplan BA, Kountakis SE. Diagnosis and pathology of unilateral maxillary sinus opacification with or without evidence of contralateral disease. Laryngoscope 2004; 114 (6): 981-5.
- Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck 2012 Jun;34 (6): 877-85.
- Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T. Nasal and Paranasal Sinus Carcinoma: Are 6.We Making Progress? A Series of 220 Patients and a Systematic Review. Cancer 2001 Dec 15; 92 (12): 3012-29.
- Akbay E, Ozgur T, Cokkeser Y. Is There Any Relationship Between the Clinical, Radiological and Histopathologic Findings in Sinonasal Polyposis. Turk Pathology Derg 2013; 29 (2): 127-33.
- Settipane GA, Lund VJ, Bernstein JM, Tos M. Nasal Polyps: Epidemiology, Pathogenesis and Treatment. Vol 1, 1 st (ed) Rhode Island: Ocean Side Pub 1997: 7-15.
- Bielamowicz S, Calcaterra TC, Watson D. İnverting papilloma of the head and neck: the UCLA update. Otolaryngol Head Neck Surg 1993 Jul; 109 (1): 71-6.
- Barbieri PG,Tomenzoli D, Morassi L, Festa R, Fernicola C. Sinonasal inverted papillomas and occupational etiology. G Ital Med Lav Ergon. 2005 Oct-Dec; 27 (4): 422-6.
- Piva MR, Santos Tde S, Martins Filho PR, Kumar PN, Souza LM, Silva LC. Inverted papilloma (Schneiderian papilloma) with involvement of the oral cavity: report of an unusual case. An Bras Dermatol. 2011 Jul-Aug; 86 (4): 779-83
- Smith SC, Patel RM Lucas DR, and McHughSinonasal Lobular Capillary Hemangioma: A JB. Clinicopathologic Study of 34 Cases Characterizing Potential for Local Recurrence. Head Neck Pathol. 2013 Jun; 7 (2): 129–34.
- Neville B, Damm D, Allen C, Bouquot J. Oral and maxillofacial pathology. Philadelphia, PA, WB Saunders 13.Company; 1995: 267-9.
- Chobillon MA, Jankowski R. Relationship between mucoceles, nasal polyposis and nasalisation. Rhinology 2004 Dec; 42 (4): 219-24.
- K el-Din, A A el-Hamd. “Nasolabial cyst: a report of eight cases and a review of the literature,” J Laryngol Otol 1999 Aug;113 (8): 747-9.
- Erisir F, Kazikdaş KC, Tuna Yalcinozan E. Giant Epidermoid Cyst of the Maxillary Sinus: A Postoperative Complication? J Craniofac Surg 2018 Sep; 29 (6): 607-8.
- Patnayak R, Jena A, Reddy MK, Chowhan AK, Rao LC, Rukhamangadha N. Epithelioid Hemangioendothelioma of Nasal Cavity. J Lab Physicians 2010 Jul-Dec; 2 (2): 111-3.
- Matsuyama A, Hisaoka M, Hashimoto H. Angioleiomyoma: a clinicopathologic and immunohistochemical reappraisal with special reference to the correlation with myopericytoma. Hum Pathol. 2007 Apr; 38 (4): 645-51.
- Arruda MM, Monteiro DY, Fernandes AM et al. Angioleiomyoma of the nasal cavity.Int Arch 19. Otorhinolaryngol. 2014 Oct; 18 (4): 409-11.
- Fitzhugh VA, Mirani N. Respiratory epithelial adenomatoid hamartoma: a review. Head Neck Pathol 2008 2 20.(3): 203-8.
- Rom D, Lee M, Chandraratnam E, Chin R, Sritharan N..Respiratory Epithelial Adenomatoid Hamartoma: An 21.Important Differential of Sinonasal Masses. Cureus. 2018 17; 10 (4): 2495.
- Gökçeer T, Noshari HK, Naiboğlu B, Atbaş A. Orbital yayılımlı etmoid sinüs osteomu. Kulak Burun Bogaz Ihtis Derg 2003; 10 (3): 117-20.
- Tsai TL, Ho CY, Guo YC, Chen W, Lin CZ. Fibrous dysplasia of the ethmoid sinus. J Chin Med Assoc 2003; 66: 131-3.
- Fırat Y, Durgun Y, Kızılay A, Selimoğlu E. Nazogastrik Sondanın Nadir Gözlenen Bir Komplikasyonu: İntranazal Fibroepitelyal Polip KBB ve BBC Derg 2008; 16: 78-81.
- Conley JJ. Melanomas of the mucous membrane of the head and neck. Laryngoscope 1989; 99: 1248-54.
- Altuntaş EE, Elagöz Ş, Özer H, Uysal İÖ, Müderris S. Kliniğinimizde tanı almış benign ve malign nazal 26.patolojili olguların retrospektif olarak değerlendirilmesi. Cumhuriyet Tıp Derg 2009; 31: 393-400.
- Ansa B, Goodman M, Ward K et al. Paranasal sinus squamous cell carcinoma incidence and survival based on surveillance, epidemiology, and end results data, 1973 to 2009. Cancer.2013; 119 (14): 2602-10.
- Husain Q, Kanumuri VV, Svider PF et al. Sinonasal adenoid cystic carcinoma: systematic review of survival 28.and treatmant strategies. Otolaryngol Head Neck Surg. 2013; 148 (1): 29-39.
- Gil Z, Carlson DL, Gupta A et al.Patterns and incidence of neural invasion in patients with cancers of the 29.paranasal sinuses. Arch Otolaryngol Head Neck Surg. 2009; 135 (2): 173–9.
Abstract
Amaç: Nazal kavite ve paranazal sinüslerin başlıca lezyonlarını inflamatuvar özellikteki benign lezyonlar oluştururken, malign lezyonlar oldukça nadirdir. Bu çalışmada, literatür bilgileri eşliğinde, nazal kavite ve paranazal sinüslerde kitle oluşturan lezyonların sıklığının ve dağılımlarının gözden geçirilmesi amaçlanmıştır. Gereç ve Yöntem: Kütahya Sağlık Bilimleri Üniversitesi Evliya Çelebi Eğitim Araştırma Hastanesi Patoloji birimimizde 2013-2018 yılları arasında raporlanan 447 olguya ait, nazal kavite ve paranazal sinüslerde görülen lezyonların histopatolojik tanıları ve yerleşimleri retrospektif olarak incelendi. Bulgular: Çalışmaya 295’i (%65,99) erkek, 152’si (%34,01) kadın olmak üzere 447 olgu dâhil edildi (E/K=1,94). Çalışmaya dâhil edilen olguların yaş ortalaması 43,54 olarak belirlendi. Histopatolojik olarak, 6 (%1,35) lezyon malign, 441 (%98,65) lezyon benign olarak saptandı. Nazal polip lezyonların büyük kısmını oluşturmaktaydı (% 82,78; 370 lezyon). Diğer benign lezyonlar: 30 (%6,72) sinonazal papillom (24 inverted papillom, 6 ekzofitik papillom), 16 (%3,58) piyojenik granülom, 11 (%2,46) mukosel, 3 (%0,68) fibrom, 2 (%0,45) nazoalveolar kist, 1 (%0,22) dev epidermoid kist, 1 (%0,22) glomanjioperisitom, 1 (%0,22) hemanjioendotelyoma, 1 (%0,22) anjioleiomyom, 1 (%0,22) respiratuvar epitelyal adenomatoid hamartom, 1 (%0,22) osteom, 1 (%0,22) fibröz displazi, 1 (%0,22) fibroepitelyal polip ve 1 (%0,22) hiperkeratotik aktinik keratoz olarak belirlendi. Malign lezyonlar ise 3 (%0,68) malign melanom, 2 (%0,45) skuamöz hücreli karsinom ve 1 (%0,22) adenoid kistik karsinom olarak saptandı. Sonuç: Sinonazal bölge lezyonları histopatojik inceleme ile benign ve malign olarak ayırt edilebilmektedir. Bu bölgedeki lezyonlar çoğunlukla benign nitelikte olup, lezyonların büyük kısmını nazal polipler oluşturmaktadır. Sinonazal bölgedeki maligniteler ise agresif tümörler olup, nadir olarak görülmektedir.
References
- Ogle OE, Weinstock RJ, Friedman E. Surgical anatomy of the nasal cavity and paranasal sinuses. Oral Maxillofac Surg Clin North Am 2012; 24: 155-66.
- Rosai J. Nasal cavity, paranasal sinuses and nasopharnyx. In: Rosai J (ed) Rosai and Ackerman's Surgical pathology. Vol 1, 10th Philadelphia; Mosby Elsevier; 2011: 291-306.
- Slootweg PJ, Chan JKC, Stelow EB, Thompson LDR. Tumors of the nasal cavity, paranasal sinuses and skull base. In: El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ (ed) WHO Classification of tumors, Pathology and Genetics of Head and Neck Tumors. Vol 9, 4rd ed. Lyon: IARC Press. 2017: 11-61.
- Kaplan BA, Kountakis SE. Diagnosis and pathology of unilateral maxillary sinus opacification with or without evidence of contralateral disease. Laryngoscope 2004; 114 (6): 981-5.
- Turner JH, Reh DD. Incidence and survival in patients with sinonasal cancer: a historical analysis of population-based data. Head Neck 2012 Jun;34 (6): 877-85.
- Dulguerov P, Jacobsen MS, Allal AS, Lehmann W, Calcaterra T. Nasal and Paranasal Sinus Carcinoma: Are 6.We Making Progress? A Series of 220 Patients and a Systematic Review. Cancer 2001 Dec 15; 92 (12): 3012-29.
- Akbay E, Ozgur T, Cokkeser Y. Is There Any Relationship Between the Clinical, Radiological and Histopathologic Findings in Sinonasal Polyposis. Turk Pathology Derg 2013; 29 (2): 127-33.
- Settipane GA, Lund VJ, Bernstein JM, Tos M. Nasal Polyps: Epidemiology, Pathogenesis and Treatment. Vol 1, 1 st (ed) Rhode Island: Ocean Side Pub 1997: 7-15.
- Bielamowicz S, Calcaterra TC, Watson D. İnverting papilloma of the head and neck: the UCLA update. Otolaryngol Head Neck Surg 1993 Jul; 109 (1): 71-6.
- Barbieri PG,Tomenzoli D, Morassi L, Festa R, Fernicola C. Sinonasal inverted papillomas and occupational etiology. G Ital Med Lav Ergon. 2005 Oct-Dec; 27 (4): 422-6.
- Piva MR, Santos Tde S, Martins Filho PR, Kumar PN, Souza LM, Silva LC. Inverted papilloma (Schneiderian papilloma) with involvement of the oral cavity: report of an unusual case. An Bras Dermatol. 2011 Jul-Aug; 86 (4): 779-83
- Smith SC, Patel RM Lucas DR, and McHughSinonasal Lobular Capillary Hemangioma: A JB. Clinicopathologic Study of 34 Cases Characterizing Potential for Local Recurrence. Head Neck Pathol. 2013 Jun; 7 (2): 129–34.
- Neville B, Damm D, Allen C, Bouquot J. Oral and maxillofacial pathology. Philadelphia, PA, WB Saunders 13.Company; 1995: 267-9.
- Chobillon MA, Jankowski R. Relationship between mucoceles, nasal polyposis and nasalisation. Rhinology 2004 Dec; 42 (4): 219-24.
- K el-Din, A A el-Hamd. “Nasolabial cyst: a report of eight cases and a review of the literature,” J Laryngol Otol 1999 Aug;113 (8): 747-9.
- Erisir F, Kazikdaş KC, Tuna Yalcinozan E. Giant Epidermoid Cyst of the Maxillary Sinus: A Postoperative Complication? J Craniofac Surg 2018 Sep; 29 (6): 607-8.
- Patnayak R, Jena A, Reddy MK, Chowhan AK, Rao LC, Rukhamangadha N. Epithelioid Hemangioendothelioma of Nasal Cavity. J Lab Physicians 2010 Jul-Dec; 2 (2): 111-3.
- Matsuyama A, Hisaoka M, Hashimoto H. Angioleiomyoma: a clinicopathologic and immunohistochemical reappraisal with special reference to the correlation with myopericytoma. Hum Pathol. 2007 Apr; 38 (4): 645-51.
- Arruda MM, Monteiro DY, Fernandes AM et al. Angioleiomyoma of the nasal cavity.Int Arch 19. Otorhinolaryngol. 2014 Oct; 18 (4): 409-11.
- Fitzhugh VA, Mirani N. Respiratory epithelial adenomatoid hamartoma: a review. Head Neck Pathol 2008 2 20.(3): 203-8.
- Rom D, Lee M, Chandraratnam E, Chin R, Sritharan N..Respiratory Epithelial Adenomatoid Hamartoma: An 21.Important Differential of Sinonasal Masses. Cureus. 2018 17; 10 (4): 2495.
- Gökçeer T, Noshari HK, Naiboğlu B, Atbaş A. Orbital yayılımlı etmoid sinüs osteomu. Kulak Burun Bogaz Ihtis Derg 2003; 10 (3): 117-20.
- Tsai TL, Ho CY, Guo YC, Chen W, Lin CZ. Fibrous dysplasia of the ethmoid sinus. J Chin Med Assoc 2003; 66: 131-3.
- Fırat Y, Durgun Y, Kızılay A, Selimoğlu E. Nazogastrik Sondanın Nadir Gözlenen Bir Komplikasyonu: İntranazal Fibroepitelyal Polip KBB ve BBC Derg 2008; 16: 78-81.
- Conley JJ. Melanomas of the mucous membrane of the head and neck. Laryngoscope 1989; 99: 1248-54.
- Altuntaş EE, Elagöz Ş, Özer H, Uysal İÖ, Müderris S. Kliniğinimizde tanı almış benign ve malign nazal 26.patolojili olguların retrospektif olarak değerlendirilmesi. Cumhuriyet Tıp Derg 2009; 31: 393-400.
- Ansa B, Goodman M, Ward K et al. Paranasal sinus squamous cell carcinoma incidence and survival based on surveillance, epidemiology, and end results data, 1973 to 2009. Cancer.2013; 119 (14): 2602-10.
- Husain Q, Kanumuri VV, Svider PF et al. Sinonasal adenoid cystic carcinoma: systematic review of survival 28.and treatmant strategies. Otolaryngol Head Neck Surg. 2013; 148 (1): 29-39.
- Gil Z, Carlson DL, Gupta A et al.Patterns and incidence of neural invasion in patients with cancers of the 29.paranasal sinuses. Arch Otolaryngol Head Neck Surg. 2009; 135 (2): 173–9.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | June 30, 2020 |
| Submission Date | September 24, 2019 |
| Published in Issue | Year 2020Volume: 59 Issue: 2 |
