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Gelişme geriliği nedeni ile başvuran çocuklarda insulin benzeri büyüme faktörü-1 ile kalsiyum, fosfor ve Vitamin D düzeyleri arasındaki ilişkinin değerlendirilmesi

Year 2023, Volume: 62 Issue: 3, 467 - 472, 18.09.2023

Eren Er , Didem Gülcü Taşkın

Abstract

Giriş-Amaç: Gelişimin tüm aşamalarında büyümede rol oynayan ana hormon, büyüme hormonu (BH) ve onun aracısı olan insülin benzeri büyüme faktörü 1'dir (IGF-1). IGF-1 ile kalsiyum, fosfor ve D vitamini arasındaki ilişki henüz hiçbir bilimsel çalışma netleştirmemiştir. Bu çalışmanın amacı, gelişme geriliği nedeni ile başvuran çocuklarda serum kalsiyum, fosfor ve D vitamini düzeylerinin insülin benzeri büyüme faktörü 1 (IGF-1) üzerindeki etkisini araştırmaktır.
Gereç-Yöntem: Bu retrospektif çalışmaya, Adana Şehir Eğitim ve Araştırma Hastanesi Çocuk Gastroenteroloji Poliklinik 1’de 01.10.2017-31.08.2022 tarihleri arasında gelişme geriliği nedeni ile başvuran 155 (80 kız, 75 erkek) çocuk dahil edildi. Antropometrik ve laboratuvar verileri hasta dosyalarından elde edildi. Serum kalsiyum, fosfor ve D vitamini ile IGF-1 arasındaki ilişki analiz edildi.
Bulgular: Çalışmaya katılan çocukların ortalama yaşı 8,13 ± 4,98 yıl idi. Katılımcıların ortalama IGF-1 düzeyi 115,06 ± 83,33 ng/ml idi. Ortalama serum kalsiyum, fosfor ve 25(OH)D seviyeleri sırasıyla 9,79 ± 0,43 mg/dl, 4,76 ± 0,59 mg/dl ve 31,49 ± 12,9 ng/ml idi. Tek değişkenli analiz sonuçları, serum fosforunun, IGF-1 düzeyi ile anlamlı derecede ilişkili olduğunu gösterdi. Ek olarak, olası karıştırıcı faktörler için düzeltildikten sonra, serum fosforu ile IGF-1 düzeyi arasında doğrusal bir ilişki gözlemlendi. Düzeltilmiş lineer regresyonun sonuçlarına göre, serum kalsiyumu ve 25(OH)D düzeyi ile IGF-1 düzeyi ile anlamlı bir ilişkili gösterilemedi (sırasıyla, β: 0,045, %95 CI: -11,583;28,863, p =0,400 ve β: -0,018, %95 CI: -0,845;0,617, p = 0,758 ). Ancak serum fosforun IGF-1 ile pozitif olarak ilişkili olduğunu gösterilmiştir (β: 0,122, %95 CI: 1,31;33,16; p = 0.034).
Sonuç: Bu çalışma, gelişme geriliği nedeni ile başvuran çocuklarda serum fosfor düzeylerini IGF-1 düzeyleri ile anlamlı ilişkili olabileceğini göstermiştir. Serum kalsiyum, fosfor ve D vitamini ile IGF-1 arasındaki ilişkiyi tam olarak aydınlatmak için ek araştırmalara ihtiyaç vardır.

Keywords

kalsiyum fosfor vitamin D IGF-1 gelişme geriliği

References

  • Bereket A, Turan S, Omar A, Berber M, Ozen A, Akbenlioglu C, vd. Serum IGF-I and IGFBP-3 levels of Turkish children during childhood and adolescence: establishment of reference ranges with emphasis on puberty. Horm Res. 2006;65(2):96-105.
  • Brabant G, von zur Mühlen A, Wüster C, Ranke MB, Kratzsch J, Kiess W, vd. Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study. Horm Res. 2003;60(2):53-60.
  • Clemmons DR. Clinical utility of measurements of insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab. Ağustos 2006;2(8):436-46.
  • Ameri P, Giusti A, Boschetti M, Murialdo G, Minuto F, Ferone D. Interactions between vitamin D and IGF-I: from physiology to clinical practice. Clin Endocrinol (Oxf). Ekim 2013;79(4):457-63.
  • Gómez JM, Maravall FJ, Gómez N, Navarro MA, Casamitjana R, Soler J. Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population. Horm Metab Res Horm Stoffwechselforschung Horm Metab. Ocak 2004;36(1):48-53.
  • Bogazzi F, Rossi G, Lombardi M, Tomisti L, Sardella C, Manetti L, vd. Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects. J Endocrinol Invest. Eylül 2011;34(8):e200-203.
  • Wei S, Tanaka H, Seino Y. Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells. Eur J Endocrinol. Ekim 1998;139(4):454-60.
  • Nesbitt T, Drezner MK. Insulin-like growth factor-I regulation of renal 25-hydroxyvitamin D-1-hydroxylase activity. Endocrinology. Ocak 1993;132(1):133-8.
  • Ameri P, Giusti A, Boschetti M, Bovio M, Teti C, Leoncini G, vd. Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. Eur J Endocrinol. Aralık 2013;169(6):767-72.
  • Soliman AT, Al Khalaf F, AlHemaidi N, Al Ali M, Al Zyoud M, Yakoot K. Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metabolism. Ocak 2008;57(1):95-102.
  • Locatelli V, Bianchi VE. Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis. Int J Endocrinol. 2014;2014:1-25.
  • Seikaly MG, Brown R, Baum M. The Effect of Recombinant Human Growth Hormone in Children With XLinked Hypophosphatemia. Pediatrics. 01 Kasım 1997;100(5):879-84.
  • Baroncelli GI, Bertelloni S, Ceccarelli C, Saggese G. Effect of growth hormone treatment on final height, phosphate metabolism, and bone mineral density in children with X-linked hypophosphatemic rickets. J Pediatr. Şubat 2001;138(2):236-43.
  • Živičnjak M, Schnabel D, Staude H, Even G, Marx M, Beetz R, vd. Three-Year Growth Hormone Treatment in Short Children with X-Linked Hypophosphatemic Rickets: Effects on Linear Growth and Body Disproportion. J Clin Endocrinol Metab. Aralık 2011;96(12):E2097-105.
  • Alexander LS, Mahajan A, Odle J, Flann KL, Rhoads RP, Stahl CH. Dietary Phosphate Restriction Decreases Stem Cell Proliferation and Subsequent Growth Potential in Neonatal Pigs. J Nutr. 01 Mart 2010;140(3):477-82.
  • Colak A, Yildiz O, Toprak B, Turkon H, Halicioglu O, Coker I. Correlation between calcium and phosphorus in cord blood and birth size in term infants. Minerva Pediatr. Haziran 2016;68(3):182-8.
  • Laviola L, Natalicchio A, Giorgino F. The IGF-I Signaling Pathway. Curr Pharm Des. 01 Mart 2007;13(7):663- 9.
  • Nakamura A, Miyado K, Yamatoya K, Kawano N, Umezawa A. Breast milk stimulates growth hormone secretion in infant mice, and phosphorus insufficiency disables this ability and causes dwarfism-like symptoms. Regen Ther. Aralık 2015;2:49-56.
  • Van Hemelrijck M, Shanmugalingam T, Bosco C, Wulaningsih W, Rohrmann S. The association between circulating IGF1, IGFBP3, and calcium: results from NHANES III. Endocr Connect. Eylül 2015;4(3):187-95.
  • Marwaha RK, Garg MK, Gupta S, Ganie MA, Gupta N, Narang A, vd. Association of insulin-like growth factor-1 and IGF binding protein-3 with 25-hydroxy vitamin D in pre-pubertal and adolescent Indian girls. J Pediatr Endocrinol Metab. 28 Mart 2018;31(3):289-95.
  • Gannagé-Yared MH, Chahine E, Farah V, Ibrahim T, Asmar N, Halaby G. Serum Insulin-Like Growth Factor 1 In Lebanese Schoolchildren And Its Relation To Vitamin D And Ferritin Levels. Endocr Pract. Nisan 2017;23(4):391-8.

Evaluation of the relationship between ınsulin-like growth factor-1 and calcium, phosphorus and Vitamin D levels in children presenting with growth retardation

Year 2023, Volume: 62 Issue: 3, 467 - 472, 18.09.2023

Eren Er , Didem Gülcü Taşkın

Abstract

Introduction-Aim: The main hormone that plays a role in growth at all stages of development is growth hormone (GH) and its mediator, insulin-like growth factor 1 (IGF-1). No scientific studies have yet clarified the relationship between IGF-1 and calcium, phosphorus and vitamin D. The aim of this study is to investigate the effect of serum calcium, phosphorus and vitamin D levels on insulin-like growth factor 1 (IGF-1) in children who are admitted with growth retardation.
Materials-Methods: 155 children (80 male, 75 female) admitted to Adana City Training and Research Hospital Pediatric Gastroenterology Outpatient Clinic 1 between 01.10.2017-31.08.2022 due to growth retardation were included in this retrospective study. Anthropometric and biochemical data files were obtained. The relationship between serum calcium, phosphorus and vitamin D and IGF-1 was analyzed.
Results: The mean age of the children participating in the study was 8.13 ± 4.98 years. The mean IGF-1 level of the participants was 115.06 ± 83.33 ng/ml. Mean serum calcium, phosphorus and 25(OH)D levels were 9.79 ± 0.43 mg/dl, 4.76 ± 0.59 mg/dl and 31.49 ± 12.9 ng/ml, respectively. Univariate analysis results showed that serum phosphorus was significantly correlated with IGF-1 level. In addition, a linear relationship was observed between serum phosphorus and IGF-1 level, after adjusting for possible confounding factors. According to the results of the adjusted linear regression, no significant correlation could be demonstrated with serum calcium and 25(OH)D level and IGF-1 level (respectively, β: 0.045, 95% CI: -11.583; 28.863, p =0.400 and β: -0.018, respectively; 95% CI: -0.845;0.617, p = 0.758 ). However, serum phosphorus has been shown to be positively associated with IGF-1 (β: 0.122, 95% CI: 1.31;33.16; p = 0.034).
Conclusion: This study showed that serum phosphorus levels may be significantly related to IGF-1 levels in children who presented with growth retardation. Additional research is needed to fully elucidate the relationship between serum calcium, phosphorus, and vitamin D and IGF-1.

Keywords

calcium phosphorus vitamin D IGF-1 growth retardation

References

  • Bereket A, Turan S, Omar A, Berber M, Ozen A, Akbenlioglu C, vd. Serum IGF-I and IGFBP-3 levels of Turkish children during childhood and adolescence: establishment of reference ranges with emphasis on puberty. Horm Res. 2006;65(2):96-105.
  • Brabant G, von zur Mühlen A, Wüster C, Ranke MB, Kratzsch J, Kiess W, vd. Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study. Horm Res. 2003;60(2):53-60.
  • Clemmons DR. Clinical utility of measurements of insulin-like growth factor 1. Nat Clin Pract Endocrinol Metab. Ağustos 2006;2(8):436-46.
  • Ameri P, Giusti A, Boschetti M, Murialdo G, Minuto F, Ferone D. Interactions between vitamin D and IGF-I: from physiology to clinical practice. Clin Endocrinol (Oxf). Ekim 2013;79(4):457-63.
  • Gómez JM, Maravall FJ, Gómez N, Navarro MA, Casamitjana R, Soler J. Relationship between 25-(OH) D3, the IGF-I system, leptin, anthropometric and body composition variables in a healthy, randomly selected population. Horm Metab Res Horm Stoffwechselforschung Horm Metab. Ocak 2004;36(1):48-53.
  • Bogazzi F, Rossi G, Lombardi M, Tomisti L, Sardella C, Manetti L, vd. Vitamin D status may contribute to serum insulin-like growth factor I concentrations in healthy subjects. J Endocrinol Invest. Eylül 2011;34(8):e200-203.
  • Wei S, Tanaka H, Seino Y. Local action of exogenous growth hormone and insulin-like growth factor-I on dihydroxyvitamin D production in LLC-PK1 cells. Eur J Endocrinol. Ekim 1998;139(4):454-60.
  • Nesbitt T, Drezner MK. Insulin-like growth factor-I regulation of renal 25-hydroxyvitamin D-1-hydroxylase activity. Endocrinology. Ocak 1993;132(1):133-8.
  • Ameri P, Giusti A, Boschetti M, Bovio M, Teti C, Leoncini G, vd. Vitamin D increases circulating IGF1 in adults: potential implication for the treatment of GH deficiency. Eur J Endocrinol. Aralık 2013;169(6):767-72.
  • Soliman AT, Al Khalaf F, AlHemaidi N, Al Ali M, Al Zyoud M, Yakoot K. Linear growth in relation to the circulating concentrations of insulin-like growth factor I, parathyroid hormone, and 25-hydroxy vitamin D in children with nutritional rickets before and after treatment: endocrine adaptation to vitamin D deficiency. Metabolism. Ocak 2008;57(1):95-102.
  • Locatelli V, Bianchi VE. Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis. Int J Endocrinol. 2014;2014:1-25.
  • Seikaly MG, Brown R, Baum M. The Effect of Recombinant Human Growth Hormone in Children With XLinked Hypophosphatemia. Pediatrics. 01 Kasım 1997;100(5):879-84.
  • Baroncelli GI, Bertelloni S, Ceccarelli C, Saggese G. Effect of growth hormone treatment on final height, phosphate metabolism, and bone mineral density in children with X-linked hypophosphatemic rickets. J Pediatr. Şubat 2001;138(2):236-43.
  • Živičnjak M, Schnabel D, Staude H, Even G, Marx M, Beetz R, vd. Three-Year Growth Hormone Treatment in Short Children with X-Linked Hypophosphatemic Rickets: Effects on Linear Growth and Body Disproportion. J Clin Endocrinol Metab. Aralık 2011;96(12):E2097-105.
  • Alexander LS, Mahajan A, Odle J, Flann KL, Rhoads RP, Stahl CH. Dietary Phosphate Restriction Decreases Stem Cell Proliferation and Subsequent Growth Potential in Neonatal Pigs. J Nutr. 01 Mart 2010;140(3):477-82.
  • Colak A, Yildiz O, Toprak B, Turkon H, Halicioglu O, Coker I. Correlation between calcium and phosphorus in cord blood and birth size in term infants. Minerva Pediatr. Haziran 2016;68(3):182-8.
  • Laviola L, Natalicchio A, Giorgino F. The IGF-I Signaling Pathway. Curr Pharm Des. 01 Mart 2007;13(7):663- 9.
  • Nakamura A, Miyado K, Yamatoya K, Kawano N, Umezawa A. Breast milk stimulates growth hormone secretion in infant mice, and phosphorus insufficiency disables this ability and causes dwarfism-like symptoms. Regen Ther. Aralık 2015;2:49-56.
  • Van Hemelrijck M, Shanmugalingam T, Bosco C, Wulaningsih W, Rohrmann S. The association between circulating IGF1, IGFBP3, and calcium: results from NHANES III. Endocr Connect. Eylül 2015;4(3):187-95.
  • Marwaha RK, Garg MK, Gupta S, Ganie MA, Gupta N, Narang A, vd. Association of insulin-like growth factor-1 and IGF binding protein-3 with 25-hydroxy vitamin D in pre-pubertal and adolescent Indian girls. J Pediatr Endocrinol Metab. 28 Mart 2018;31(3):289-95.
  • Gannagé-Yared MH, Chahine E, Farah V, Ibrahim T, Asmar N, Halaby G. Serum Insulin-Like Growth Factor 1 In Lebanese Schoolchildren And Its Relation To Vitamin D And Ferritin Levels. Endocr Pract. Nisan 2017;23(4):391-8.
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Details

Primary Language Turkish
Subjects Pediatric Endocrinology, Pediatric Gastroenterology
Journal Section Research Articles
Authors

Eren Er 0000-0003-4770-0365

Didem Gülcü Taşkın 0000-0002-2746-3799

Publication Date September 18, 2023
Submission Date November 3, 2022
Published in Issue Year 2023Volume: 62 Issue: 3

Cite

Vancouver Er E, Gülcü Taşkın D. Gelişme geriliği nedeni ile başvuran çocuklarda insulin benzeri büyüme faktörü-1 ile kalsiyum, fosfor ve Vitamin D düzeyleri arasındaki ilişkinin değerlendirilmesi. EJM. 2023;62(3):467-72.
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