Kronik Obstrüktif Akciğer Hastalığı Olan Hastalarda Retina Sinir Lifi Tabakasının Morfometrik Yapısının Optik Koherens Tomografi ile İncelenmesi
Abstract
Amaç: Global İnitiative For Chronic Obstructive Lung Disease (GOLD)’a göre Kronik Obstrüktif Akciğer Hastalığı (KOAH) tanısı alan bireylerde retina sinir lifi tabakası (RSLT)’nda oluşan değişimlerin Spektral Domain-Optik Koherans Tomografi (SD-OKT) ile incelenmesi amaçlanmaktadır.
Gereç ve Yöntem: Çalışmaya 18 yaş ve üstü 76 KOAH’lı, 80 sağlıklı birey dahil edilmiştir. KOAH‘lı hastalar GOLD’a göre tanı konularak A, B, C ve D olmak üzere dört grupta incelenmiştir. RSLT kalınlıkları optik sinir başı (OSB) merkezli superior, inferior, temporal ve nasal olmak üzere dört kadranda incelenmiştir.
Bulgular: OSB merkezli peripapillar alanda RSLT kalınlığının; inferior kadranda GOLD B, GOLD C ve GOLD D gruplarında kontrol grubuna göre daha ince (p=0.002), temporal kadranda ise GOLD A ve GOLD C gruplarında en kalın olduğu tesbit edilmştir (p=0.001).
Sonuçlar: Çalışmamıza dâhil edilen KOAH’lı hastalar güncellenen GOLD kriterlerine göre değerlendirilerek gruplara ayrılmıştır ve bu yönüyle literatüre zenginlik katmış olduğunu düşünmekteyiz. KOAH’ın toplumumuzda erkeklerde kadınlara göre daha yaygın bulunduğu belirlenmiştir. KOAH’lıların retinal fonksiyonlarının değerlendirilmesi için göz hastalıkları açısından konsülte edilmesi uygun olacaktır.
Keywords
Morfometri Kronik Obstruktif Akciğer Hastalığı KOAH SD-OKT Retina Sinir lifi tabakası RSLT.
Supporting Institution
İnönü Üniversitesi Bilimsel Araştırma Projeleri Koordinatörlüğü
Project Number
TDK-2018-771
References
- Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. Am J Respir Crit Car Med. 2017; 195: 557-82.
- Pesci A, Balbi B, Majori M, et al. Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur Respir J 1998; 12(2): 380–6.
- Xin C, Wang J, Zhang W,et al. Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS). Eye 2014; 28(4): 415–21.
- Özçimen M, Sakarya Y, Kurtipek E, et al. Peripapillary choroidal thickness in patients with chronic obstructive pulmonary disease. Cutan Ocul Toxicol 2016; 35: 26-30.
- Roland M, Bhowmik A, Sapsford RJ, et al. Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease. Thorax 2001; 56: 30–5.
- Ozer T, Altin R, Ugurbas SH, et al. Color Doppler evaluation of the ocular arterial flow changes in chronic obstructive pulmonary disease. Eur J Radiol 2006; 57(1): 63-8.
- Yanagi M, Kawasaki R, Wang JJ, et al. Vascular risk factors in glaucoma: a review. Clin Experiment Ophthalmol 2011; 39(3): 252-8.
- Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008; 146: 496–500.
- Adhi M, Duker JS. Optical coherence tomography-current and future applications. Curr Opin Ophthalmol 2013; 24(3): 213–21.
- Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009; 33: 1165-85.
- Mannino DM, Homa DM, Akinbami LJ, et al. Chronic obstructive pulmonary disease surveillance – United States, 1971–2000. MMWR Surveill Summaries 2002; 51: 1–16.
- Korkut S. Evaluation of patients with depression which come with chronic obstructive pulmonary disease (COPD) attack to the emergency medicine. Faculty of Medicine Department of Chest Diseases [Master thesis], Düzce, Düzce Universty, 2012.
- Kara M, Mirici A. Loneliness, depression, and social support of Turkish patients with chronic obstructive pulmonary disease and their spouses. J Nurs Scholarsh 2004; 36: 331-6.
- Türkkan S. Prevelance of cronıc obstuctive pulmonary disease ın fırst degree relatives of COPD patients, Faculty of Medicine Department of Chest Diseases. İ.Ü [Master thesis], 2012.
- Congleton J. The pulmonary cachexia syndrome; aspects of energy balance. Proc Nutr Soc 1999; 58: 321-8.
- Salepçi B, Eren A, Çağlayan B, et al. The effect of body mass index on functional parameters and quality of life in COPD patients. Tüberculosis and Thorax 2007; 55(4): 342-9.
- Ghee1 YT, Mustapha1 M, Harun R, et al. Retinal nerve fiber layer thickness in chronic obstructive pulmonary disease: An optical coherence tomography study. Asian J Ophthalmol 2017; 15: 151-8.
- Ugurlu E, Pekel G, Altinisik G, et al. New aspect for systemic effects of COPD: eye findings. Clin Respir J 2018; 12:247–52.
- Domej W, Oettl K, Renner W. Oxidative stress and free radicals in COPD– implications and relevance for treatment. Int J Chron Obstruct Pulmon Dis 2014; 9(1): 1207–24.
- Palombi K, Renard E, Levy P, et al. Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoea. Br J Ophthalmol. 2006; 90(7): 879–82.
- Polak K, Luksch A, Frank B, et al. Regulation of human retinal blood flow by endothelin-1. Exp Eye Res 2003; 76: 633–40. Donati G, Pournaras CJ, Munoz JL, et al. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci. 1995; 36: 2228–37.
- Sofia M, Mormile M, Faraone S, et al. Increased 24-h endothelin-1 urinary excretion in patients with chronic obstructive pulmonary disease. Respiration 1994; 61:263–8.
- Agusti A, Soriano JB. COPD as a systemic disease. Chronic Obstr Pulm Dis 2008; 5: 133–8.
- Nikolaou E, Trakada G, Prodromakis E, et al. Evaluation of arterial endothelin-1 levels, before and during a sleep study, in patients with bronchial asthma and chronic obstructive pulmonary disease. Respiration 2003; 70(6): 606–10.
- Alim S, Demir HD, Yilmaz A, et al. To evaluate the effect of chronic obstructive pulmonary disease on retinal and choroidal thicknesses measured by optical coherence tomography. J Ophthalmol 2019; Oct:1-5.
- Gok M, Ozer MA, B, Ozen S, et al. The evaluation of retinal and choroidal structural changes by optical coherence tomography in patients with chronic obstructive pulmonary disease. Curr Eye Res 2018; 43(1): 116–21.
- Turan M. The evaluation of retinal nerve fiber layer thickness by optical coherence tomography in patients with chronic obstructive pulmonary disease. Faculty of Medicine Department of Ophthalmology [Master thesis], Konya, Selcuk University, 2009.
- Martinez A, Proupim N, Sanchez M. Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients. Br J Ophthalmol 2008; 92: 1069-75.
- Kırbas S, Tufekci A, Turkyilmaz K, et al. Evaluation of the retinal changes in patients with chronic migraine. Acta Neurol Belg 2013; 113(2): 167-72.
Investigation Of The Morphometric Structure Of The Retinal Nerve Fiber Layer İn Patients With Chronic Obstructive Pulmonary Disease By Optical Coherence Tomography
Abstract
Aim: To examine the changes in the retinal nerve fiber layer (RNFL) with Spectral-Domain Optical Coherence Tomography (SD-OCT) in individuals diagnosed with Chronic Obstructive Pulmonary Disease (COPD), according to Global Initiative For Chronic Obstructive Lung Disease (GOLD).
Materials and Methods: The study consisted of people 18 years or older, including 76 patients with COPD and 80 healthy control groups. Patients with COPD have been examined in four groups A, B, C and D, according to GOLD. RNFL thickness was examined through Optic Nerve Head (ONH) centered in four quadrants; superior, inferior, temporal, and nasal.
Results: In the Optic Nerve Head-centered peripapillary area, the RNFL thickness was observed the thinnest in the inferior quadrant in GOLD B, GOLD C, and GOLD D groups (p=0.002). In the temporal quadrant, GOLD A and GOLD C groups were the thickest (p=0.001).
Conclusion: The patients with COPD included in our study were divided into groups by evaluating them according to the updated GOLD criteria and we think that this aspect has added richness to the literature. It would be appropriate to consult in terms of eye diseases for the evaluation of retinal functions in COPD patients.
Project Number
TDK-2018-771
References
- Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. Am J Respir Crit Car Med. 2017; 195: 557-82.
- Pesci A, Balbi B, Majori M, et al. Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. Eur Respir J 1998; 12(2): 380–6.
- Xin C, Wang J, Zhang W,et al. Retinal and choroidal thickness evaluation by SD-OCT in adults with obstructive sleep apnea-hypopnea syndrome (OSAS). Eye 2014; 28(4): 415–21.
- Özçimen M, Sakarya Y, Kurtipek E, et al. Peripapillary choroidal thickness in patients with chronic obstructive pulmonary disease. Cutan Ocul Toxicol 2016; 35: 26-30.
- Roland M, Bhowmik A, Sapsford RJ, et al. Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease. Thorax 2001; 56: 30–5.
- Ozer T, Altin R, Ugurbas SH, et al. Color Doppler evaluation of the ocular arterial flow changes in chronic obstructive pulmonary disease. Eur J Radiol 2006; 57(1): 63-8.
- Yanagi M, Kawasaki R, Wang JJ, et al. Vascular risk factors in glaucoma: a review. Clin Experiment Ophthalmol 2011; 39(3): 252-8.
- Spaide RF, Koizumi H, Pozzoni MC. Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 2008; 146: 496–500.
- Adhi M, Duker JS. Optical coherence tomography-current and future applications. Curr Opin Ophthalmol 2013; 24(3): 213–21.
- Barnes PJ, Celli BR. Systemic manifestations and comorbidities of COPD. Eur Respir J 2009; 33: 1165-85.
- Mannino DM, Homa DM, Akinbami LJ, et al. Chronic obstructive pulmonary disease surveillance – United States, 1971–2000. MMWR Surveill Summaries 2002; 51: 1–16.
- Korkut S. Evaluation of patients with depression which come with chronic obstructive pulmonary disease (COPD) attack to the emergency medicine. Faculty of Medicine Department of Chest Diseases [Master thesis], Düzce, Düzce Universty, 2012.
- Kara M, Mirici A. Loneliness, depression, and social support of Turkish patients with chronic obstructive pulmonary disease and their spouses. J Nurs Scholarsh 2004; 36: 331-6.
- Türkkan S. Prevelance of cronıc obstuctive pulmonary disease ın fırst degree relatives of COPD patients, Faculty of Medicine Department of Chest Diseases. İ.Ü [Master thesis], 2012.
- Congleton J. The pulmonary cachexia syndrome; aspects of energy balance. Proc Nutr Soc 1999; 58: 321-8.
- Salepçi B, Eren A, Çağlayan B, et al. The effect of body mass index on functional parameters and quality of life in COPD patients. Tüberculosis and Thorax 2007; 55(4): 342-9.
- Ghee1 YT, Mustapha1 M, Harun R, et al. Retinal nerve fiber layer thickness in chronic obstructive pulmonary disease: An optical coherence tomography study. Asian J Ophthalmol 2017; 15: 151-8.
- Ugurlu E, Pekel G, Altinisik G, et al. New aspect for systemic effects of COPD: eye findings. Clin Respir J 2018; 12:247–52.
- Domej W, Oettl K, Renner W. Oxidative stress and free radicals in COPD– implications and relevance for treatment. Int J Chron Obstruct Pulmon Dis 2014; 9(1): 1207–24.
- Palombi K, Renard E, Levy P, et al. Non-arteritic anterior ischaemic optic neuropathy is nearly systematically associated with obstructive sleep apnoea. Br J Ophthalmol. 2006; 90(7): 879–82.
- Polak K, Luksch A, Frank B, et al. Regulation of human retinal blood flow by endothelin-1. Exp Eye Res 2003; 76: 633–40. Donati G, Pournaras CJ, Munoz JL, et al. Nitric oxide controls arteriolar tone in the retina of the miniature pig. Invest Ophthalmol Vis Sci. 1995; 36: 2228–37.
- Sofia M, Mormile M, Faraone S, et al. Increased 24-h endothelin-1 urinary excretion in patients with chronic obstructive pulmonary disease. Respiration 1994; 61:263–8.
- Agusti A, Soriano JB. COPD as a systemic disease. Chronic Obstr Pulm Dis 2008; 5: 133–8.
- Nikolaou E, Trakada G, Prodromakis E, et al. Evaluation of arterial endothelin-1 levels, before and during a sleep study, in patients with bronchial asthma and chronic obstructive pulmonary disease. Respiration 2003; 70(6): 606–10.
- Alim S, Demir HD, Yilmaz A, et al. To evaluate the effect of chronic obstructive pulmonary disease on retinal and choroidal thicknesses measured by optical coherence tomography. J Ophthalmol 2019; Oct:1-5.
- Gok M, Ozer MA, B, Ozen S, et al. The evaluation of retinal and choroidal structural changes by optical coherence tomography in patients with chronic obstructive pulmonary disease. Curr Eye Res 2018; 43(1): 116–21.
- Turan M. The evaluation of retinal nerve fiber layer thickness by optical coherence tomography in patients with chronic obstructive pulmonary disease. Faculty of Medicine Department of Ophthalmology [Master thesis], Konya, Selcuk University, 2009.
- Martinez A, Proupim N, Sanchez M. Retinal nerve fibre layer thickness measurements using optical coherence tomography in migraine patients. Br J Ophthalmol 2008; 92: 1069-75.
- Kırbas S, Tufekci A, Turkyilmaz K, et al. Evaluation of the retinal changes in patients with chronic migraine. Acta Neurol Belg 2013; 113(2): 167-72.
Details
| Primary Language | English |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Research Articles |
| Authors | |
| Project Number | TDK-2018-771 |
| Publication Date | June 10, 2024 |
| Submission Date | April 3, 2023 |
| Published in Issue | Year 2024Volume: 63 Issue: 2 |
