Abstract
Hodgkin lymphoma is lymphoid neoplasm in which the malignant cells admixed with a
heterogeneous population of non-neoplastic inflammatory cells. A combination of
Doxorubicin, Bleomycin, Vinblastine, and Dacarbazine (ABVD) is the most commonly
used chemotherapy regime for Hodgkin lymphoma. In this case report, we present a
patient with Hodgkin lymphoma who developed bilateral auricular hematoma after a
first time administrition of ABVD treatment. A 27-year-old female patient was presented
to the hematology outpatient clinic with a swelling in the neck for two weeks. An
excisional biopsy performed from the left axillary region. The pathology report
demonstrated classical Hodgkin lymphoma was noticed to be consistent with mixed
cellular type. First dose ABVD protocol was administered to the patient. One week after
chemotherapy, swelling and discoloration were observed in the patient's bilateral
auricles without a history of trauma. The patient was consulted to the Department of
Otorhinolarngology-Head and Neck Surgery. Bilateral drainage of auricular hematoma
was performed immediately. Intravenous ciprofloxacin was also administered. The
auricular hematoma did not reoccur after the subsequent chemotherapy treatments.
References
- Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1): 7-30.
- Sant M, Allemani C, Tereanu C, De Angelis R, Capocaccia R, Visser O. et al. HAEMACARE Working Group. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010; 116(19): 3724-34.
- Smith A, Howell D, Patmore R, Jack A, Roman E. Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network. Br J Cancer. 2011; 105(11): 1684-92.
- Federico M, Luminari S, Iannitto E, Polimeno G, Marcheselli L, Montanini A. et al. ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin's lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial. J Clin Oncol. 2009; 27(5): 805-11.
- Greywoode JD, Pribitkin EA, Krein H. Management of auricular hematoma and the cauliflower ear. Facial Plast Surg. 2010; 26(6): 451-5.
- Anesi GL, Levine D, Attar EC, Fathi AT. Bilateral ear swelling and erythema after chemotherapy: a case of ara-C ears. J Clin Oncol. 2012; 30(16): 146.
- Sahu KK, Yanamandra U, Malhotra P. Ara-c related red ear syndrome. Ear Nose Throat J. 2019; 98(3): 169-70.
- Sun Y, Yang SS, Tan LS. A case of red ears. Indian J Dermatol Venereol Leprol. 2020; 86(3): 325-28.
- Jaruvijitrattana P, Chanprapaph K. Bilateral ear swelling and erythema after chemotherapy: a case report of ara-c ears. Case Rep Dermatol. 2019; 11(2): 226-32.
- Kong TH, Han SM, Seo YJ. Chondritis of the ear after docetaxel-carboplatin chemotherapy. J Oncol Pharm Pract. 2019; 25(4): 975-79.
Abstract
Hodgkin lenfoma; malign hücrelerin, neoplastik olmayan inflamatuar hücrelerle heterojen bir şekilde karıştığı lenfoid neoplazmdır. Doksorubisin, Bleomisin, Vinblastin ve Dakarbazin (ABVD) kombinasyonu, Hodgkin lenfoma için en sık kullanılan kemoterapi rejimidir. Bu olgu sunumunda, ilk kez ABVD tedavisi uygulandıktan sonra bilateral auriküler hematom gelişen Hodgkin lenfomalı bir hastayı sunuyoruz. 27 yaşında kadın hasta, iki haftadır devam eden boyunda şişlik şikayeti ile hematoloji polikliniğine başvurdu. Sol aksiller bölgeden yapılan eksizyonel biyopsi sonucunda patoloji raporu klasik Hodgkin lenfomanın mikst hücreli tip ile uyumlu olduğu saptandı. Hastaya ilk doz ABVD protokolü uygulandı. Kemoterapiden bir hafta sonra travma öyküsü olmayan hastanın iki taraflı kulak kepçelerinde şişlik ve renk değişikliği gözlendi. Hasta Kulak Burun Boğaz-Baş Boyun Cerrahisi bölümüne konsülte edildi. Kulak hematomunun iki taraflı drenajı hemen yapıldı. Ayrıca intravenöz siprofloksasin uygulandı. Kulak hematomu sonraki kemoterapi tedavilerinden sonra tekrar ortaya çıkmadı.
References
- Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017; 67(1): 7-30.
- Sant M, Allemani C, Tereanu C, De Angelis R, Capocaccia R, Visser O. et al. HAEMACARE Working Group. Incidence of hematologic malignancies in Europe by morphologic subtype: results of the HAEMACARE project. Blood. 2010; 116(19): 3724-34.
- Smith A, Howell D, Patmore R, Jack A, Roman E. Incidence of haematological malignancy by sub-type: a report from the Haematological Malignancy Research Network. Br J Cancer. 2011; 105(11): 1684-92.
- Federico M, Luminari S, Iannitto E, Polimeno G, Marcheselli L, Montanini A. et al. ABVD compared with BEACOPP compared with CEC for the initial treatment of patients with advanced Hodgkin's lymphoma: results from the HD2000 Gruppo Italiano per lo Studio dei Linfomi Trial. J Clin Oncol. 2009; 27(5): 805-11.
- Greywoode JD, Pribitkin EA, Krein H. Management of auricular hematoma and the cauliflower ear. Facial Plast Surg. 2010; 26(6): 451-5.
- Anesi GL, Levine D, Attar EC, Fathi AT. Bilateral ear swelling and erythema after chemotherapy: a case of ara-C ears. J Clin Oncol. 2012; 30(16): 146.
- Sahu KK, Yanamandra U, Malhotra P. Ara-c related red ear syndrome. Ear Nose Throat J. 2019; 98(3): 169-70.
- Sun Y, Yang SS, Tan LS. A case of red ears. Indian J Dermatol Venereol Leprol. 2020; 86(3): 325-28.
- Jaruvijitrattana P, Chanprapaph K. Bilateral ear swelling and erythema after chemotherapy: a case report of ara-c ears. Case Rep Dermatol. 2019; 11(2): 226-32.
- Kong TH, Han SM, Seo YJ. Chondritis of the ear after docetaxel-carboplatin chemotherapy. J Oncol Pharm Pract. 2019; 25(4): 975-79.
Details
| Primary Language | English |
|---|---|
| Subjects | Haematology, Internal Diseases, Otorhinolaryngology |
| Journal Section | Case Reports |
| Authors | |
| Publication Date | September 9, 2024 |
| Submission Date | January 23, 2024 |
| Acceptance Date | March 11, 2024 |
| Published in Issue | Year 2024Volume: 63 Issue: 3 |
