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Araştırma Makalesi
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Prospective-observational evaluation of the 50 meningomyelocele neonates

Yıl 2017, Cilt: 56 Sayı: 3, 135 - 139, 01.09.2017

Senem Alkan Özdemir , Nail Özdemir Esra Arun Özer

https://doi.org/10.19161/etd.391545
Cited By: 1

Öz

Aim: We aimed to analyze the clinical outcomes and maternal sociodemographic features of the patients followed in the neonatal intensive care unit with meningomyelocele diagnosis.

Materials and Methods: Babies with meningomyelocele followed in the unit between January 2012 and December 2014 were analyzed prospectively and observationally. Perinatal data, maternal sociodemographic features, prenatal diagnosis, features of the sac, operation time, hospitalization duration, associated abnormalities, need of ventriculoperitoneal shunt, shunt infection, controls of policlinic, rehospitalization frequency and causes for each baby were recorded. Eighteen months after birth, children were assessed by the Denver Development Screening Test-II for psychomotor delay and the children were classified as normal, borderline delay and significant delay.

Results: Fifty neonates admitted to the unit were diagnosed as meningomyelocele during the study period. Mean birth weight and gestational age were 3012±485 (1850-4000) g and 37.9±1.4 (35-42) weeks, respectively. 90% of the mothers had never used folic acid during pregnancy. Twenty-five of sacs were located in the lumbosacral, 24 in the thoracolumbar, and 1 in the cervicothoracic regions. Paraplegia was determined in 27 neonates. Mean operation time was within 4.9 ± 3 days. Among all neonates, 35 were diagnosed as hydrocephaly, 33 as hydronephrosis, 24 as Chiari type 2 malformation, 22 as pes equinovarus, and 16 as kyphosis. Denver Development Screening Test-II were normal in 14 babies whereas borderline delay in 31 and significant delay in 5.

Conclusion: Educating women, folic acid use during pregnancy and fortification of food seem to be the important for reducing incidence of meningomyelocele.

Anahtar Kelimeler

Folic acid meningomyelocele neural tube defect neonate

Kaynakça

  • Nievelstein RA, Hartwiq NG, Vermeji-Keers C, Valk J. Embriyonic development of the mammalian caudal neural tube. Teratology 1993;48 (1):21-31.
  • Mitchell LE, Adzick NS, Melchionne J, Pasquvariella PS, Suttan LN, Whitehead AS. Spina bifida. Lancet 2004;364(9448):1885-95.
  • Karabaglı P, Gurcan T, Celik ZE, Karabaglı H. Myelomeningoceles and meningoceles: A clinicopathologic study of 43 cases.J Neurol Sci (Turk) 2014;31(2):335-45.
  • Oakeshott P, Hunt GM, Poultan A, Reid F. Expectation of life and unexpected death in open spina bifida: A 40-year complete, non-selective, longitudinal cohort study. Dev Med Child Neural 2010;52(8):749-53.
  • Kahn L, Mbabuike N, Valle-Giler EP, et al. Fetal surgery: The ochsner experience with in utero spina bifida repair. Ochsner J 2014;14(1):112-8.
  • Frankenburg WK, Doddr J, Archer P, Shapino H, Bresnick B. The Denver II: A major revision and restandardization of the Denver Development Screening Test. Pediatrics 1992;89(1):91-7.
  • Tekgul H, Gauvreau K, Soul J, et al. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics 2006;117(4):1270-80.
  • Perry VL, Albright AL, Adelson PD. Operative nuances of myelomeningocele closure. Neurosurgery 2002;51(3):719-23.
  • Food and Drug Administration. Food standarts of identity for enriched grain products to require addition of folic acid. Final Rule 21 CFR 1996;131(1):3702-37.
  • MRC Vitamin Study Research Group. Prevention of neural tube defects: Results of the medical research council vitamin study. Lancet 1991;338(8760):131-7.
  • Lloyd J. Folic acid and the prevention of neural tube defects. London: Department of Health. 1992
  • De Wals P, Tairou F, Van Allen MI, et al. Reduction in neural-tube defects after folic acid fortification in Canada. N Eng J Med 2007;357(2):135-42.
  • Northrup H, Volcik KA. Spina bifida and other neural tube defects. Curr Probl Pediatr 2000;30(10):315-37.
  • Bowman RM, McLone DG, Grant JA, Tomita T, Ho JA. Spina bifida outcome: A 25 year prospective. Pediatr Neurosurg 2001;34(3):114-20.
  • Rosano A, Botto LD, Botting B, Mastroiacozzo P. Infant mortality and congenital anomalies from 1950-1994: An international perspective. J Epidemiol Community Health 2000;54(9):660-6.
  • Pana D. Surgical complications of open spinal dysraphism. Neurosurg Clin N Am 1995;6(2):243-57.

Meningomyeloselli 50 yenidoğanın prospektif-gözlemsel değerlendirilmesi

Yıl 2017, Cilt: 56 Sayı: 3, 135 - 139, 01.09.2017

Senem Alkan Özdemir , Nail Özdemir Esra Arun Özer

https://doi.org/10.19161/etd.391545
Cited By: 1

Öz

Amaç: Yenidoğan yoğun bakım ünitesine meningomyelosel tanısıyla yatırılan hastaların klinik sonuçları ile annenin sosyodemografik özelliklerini araştırmayı amaçladık.

Gereç ve Yöntem: Ocak 2012 - Aralık 2014 tarihleri arasında meningomyelosel nedeni ile yatan tüm yenidoğanların perinatal bilgileri, annenin sosyodemografik özellikleri, prenatal tanısı, kesenin özellikleri, operasyon zamanı, hastanede yatış süresi, eşlik eden ek anomalileri, ventriküloperitoneal şant gerekliliği, şant enfeksiyonu, taburculuk sonrası poliklinik kontrolleri ile hastaneye yatış sıklığı ve yatış nedenleri prospektif-gözlemsel olarak kaydedildi. Denver Gelişimsel Tarama Testi-II ile postnatal 18. ayda psikomotor değerlendirme yapıldı ve çocuklar normal, sınırda gerilik ve ciddi gerilik şeklinde sınıflandı.

Bulgular: İki yılda yatırılan 50 hastanın ortalama doğum ağırlığı 3012±485 (1850-4000) g, gestasyon haftası 37.9±1.4 (35-42) hafta idi. Hiçbir anne prekonsepsiyonel dönemde folik asid kullanmamıştı. Gebelikte %90’ında kullanım yoktu. Keselerin 25’i torakolomber, 24’ü lumbosakral ve 1’i servikotorasik yerleşimliydi. Alt ekstremite muayenesinde 27 yenidoğan paraplejik, 11’i minimal ve 12’si ise tam hareketliydi. Ortalama operasyon günü 4.9±3 gündü. Hidrosefali 35, hidronefroz 33, Chiari tip 2 malformasyonu 24, pes ekinovarus 22, kifoz 16 yenidoğanda mevcuttu. Denver Gelişimsel Tarama Testi–II ile 14 bebekte normal, 31 bebekte sınırda ve 5 bebekte ise ciddi gerilik saptandı.

Sonuç: Gebelikte folik asid alınması, tüketilen gıdalardaki folik asid miktarının arttırılması ve kadınların eğitimi meningomyeloselin insidansının azaltılmasında önemlidir.

Anahtar Kelimeler

Folik asit meningomyelosel nöral tüp defekti yenidoğan

Kaynakça

  • Nievelstein RA, Hartwiq NG, Vermeji-Keers C, Valk J. Embriyonic development of the mammalian caudal neural tube. Teratology 1993;48 (1):21-31.
  • Mitchell LE, Adzick NS, Melchionne J, Pasquvariella PS, Suttan LN, Whitehead AS. Spina bifida. Lancet 2004;364(9448):1885-95.
  • Karabaglı P, Gurcan T, Celik ZE, Karabaglı H. Myelomeningoceles and meningoceles: A clinicopathologic study of 43 cases.J Neurol Sci (Turk) 2014;31(2):335-45.
  • Oakeshott P, Hunt GM, Poultan A, Reid F. Expectation of life and unexpected death in open spina bifida: A 40-year complete, non-selective, longitudinal cohort study. Dev Med Child Neural 2010;52(8):749-53.
  • Kahn L, Mbabuike N, Valle-Giler EP, et al. Fetal surgery: The ochsner experience with in utero spina bifida repair. Ochsner J 2014;14(1):112-8.
  • Frankenburg WK, Doddr J, Archer P, Shapino H, Bresnick B. The Denver II: A major revision and restandardization of the Denver Development Screening Test. Pediatrics 1992;89(1):91-7.
  • Tekgul H, Gauvreau K, Soul J, et al. The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants. Pediatrics 2006;117(4):1270-80.
  • Perry VL, Albright AL, Adelson PD. Operative nuances of myelomeningocele closure. Neurosurgery 2002;51(3):719-23.
  • Food and Drug Administration. Food standarts of identity for enriched grain products to require addition of folic acid. Final Rule 21 CFR 1996;131(1):3702-37.
  • MRC Vitamin Study Research Group. Prevention of neural tube defects: Results of the medical research council vitamin study. Lancet 1991;338(8760):131-7.
  • Lloyd J. Folic acid and the prevention of neural tube defects. London: Department of Health. 1992
  • De Wals P, Tairou F, Van Allen MI, et al. Reduction in neural-tube defects after folic acid fortification in Canada. N Eng J Med 2007;357(2):135-42.
  • Northrup H, Volcik KA. Spina bifida and other neural tube defects. Curr Probl Pediatr 2000;30(10):315-37.
  • Bowman RM, McLone DG, Grant JA, Tomita T, Ho JA. Spina bifida outcome: A 25 year prospective. Pediatr Neurosurg 2001;34(3):114-20.
  • Rosano A, Botto LD, Botting B, Mastroiacozzo P. Infant mortality and congenital anomalies from 1950-1994: An international perspective. J Epidemiol Community Health 2000;54(9):660-6.
  • Pana D. Surgical complications of open spinal dysraphism. Neurosurg Clin N Am 1995;6(2):243-57.
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Senem Alkan Özdemir 0000-0003-0474-7120

Nail Özdemir 0000-0002-1969-604X

Esra Arun Özer 0000-0003-2634-7136

Yayımlanma Tarihi 1 Eylül 2017
Gönderilme Tarihi 12 Ocak 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 56 Sayı: 3

Kaynak Göster

Vancouver Alkan Özdemir S, Özdemir N, Arun Özer E. Meningomyeloselli 50 yenidoğanın prospektif-gözlemsel değerlendirilmesi. ETD. 2017;56(3):135-9.

Cited By

Opere edilen meningomyelosel olgularının retrospektif değerlendirilmesi
Adıyaman Üniversitesi Sağlık Bilimleri Dergisi
https://doi.org/10.30569/adiyamansaglik.1313886
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