Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes

Hüseyin Ekici; Fırat Ökmen; Didem Gül Sarıtaş; Metehan İmamoğlu; Turnagül Eker; Ahmet Ergenoğlu

doi:10.19161/etd.1262496

TR EN

Gebelikte primer otoimmun trombositopeni: maternal ve fetal sonuçlar

Öz

Amaç: Primer otoimmün trombositopenili (ITP) gebelerde klinik özellikler, maternal ve yenidoğan sonuçlarını değerlendirmek. Gereç ve Yöntem: 2011 ve 2021 yılları arasında referans bir merkezde, Kadın Hastalıkları ve Doğum Bölümünde antenatal takip ve doğumları gerçekleştirilen tüm ITP’ li gebe kadınlar retrospektif olarak incelendi. Hastalar antenatal tedavi modalitelerine göre üç grupta değerlendirildi. Bulgular: Çalışmaya ITP’ li 42 gebe kadın dahil edildi. Gebe kadınların 29’ u (%69) gebelik öncesi, 13’ ü (%31) gebelik sırasında ITP tanısı aldı. Gebe kadınların 17’ si (%41) antenatal dönemde tedavi almaz iken, 25’ i (%59) antenatal tedavi aldı. Postpartum hemoraji steroid+İVİG grubunda daha sık görüldü (%50). 42 gebelikten 43 (bir ikiz gebelik, 41 tekil gebelik) canlı doğum gerçekleşdi. Üç yenidoğanda (%7) trombositopeni görülürken, bunlardan birinde intrakranial kanama izlendi. Sonuç: ITP ile komplike gebeliklerde platelet sayısı orta veya ciddi derecede düşüktür, olumsuz maternal ve neonatal sonuçlara neden olabilir. İTP’ li olgularda postpartum hemoraji önemli bir maternal morbidite nedenidir. Bu nedenle İTP ‘li gebeler, postpartum hemorajiyi etkin bir şekilde yöneten merkezlerde doğurtulmalıdır.

Anahtar Kelimeler

Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes

Öz

Aim: To evaluate clinical characteristics, maternal and neonatal outcomes among pregnant women with primary autoimmune thrombocytopenia (ITP). Materials and methods: All pregnant women with ITP who had undergone antenatal follow-up and delivery at the Department of Obstetrics and Gynecology at a referral center, between 2011 and 2021, were retrospectively investigated. Patients were evaluated in three groups according to antenatal treatment modality. Results: 42 pregnant women with ITP were included in the study. A total of 29 (%69) pregnant womenhad been diagnosed with ITP before pregnancy and 13(%31) were diagnosed during pregnancy. 17 (%41) pregnant women did not receive any antenatal treatment, and 25 (%59) pregnant women receieved treatment. Postpartum haemorrhage (%50) was reported more frequently in the steroids+IVIG group. A total of 42 pregnancies, 43 babies (one twin pregnancy, 41 singletons) were liveborn. Three neonates (%7) had thrombocytopenia and one of them had intracranial haemorrhage. Conclusions: In pregnancies complicated with ITP, the platelet count is moderately or severely low, which can have adverse maternal and neonatal outcomes. Postpartum haemorrhage is a significant cause of maternal morbidity in cases with ITP. Therefore, pregnant women with ITP should be delivered in facilities that can adequately manage postpartum haemorrhage.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Sağlık Kurumları Yönetimi

Bölüm

Araştırma Makalesi

Yazarlar

Hüseyin Ekici
0000-0001-8541-1199
Türkiye

Fırat Ökmen ^*
0000-0001-7731-0814
Türkiye

Didem Gül Sarıtaş
0000-0002-6455-2328
Türkiye

Metehan İmamoğlu
0000-0002-7803-8012
United States

Turnagül Eker
0000-0002-7750-0113
Türkiye

Ahmet Ergenoğlu
0000-0002-4804-3232
Türkiye

Yayımlanma Tarihi

15 Mart 2023

Gönderilme Tarihi

26 Haziran 2022

Kabul Tarihi

11 Ağustos 2022

Yayımlandığı Sayı

Yıl 2023 Cilt: 62 Sayı: 1

DOI

https://doi.org/10.19161/etd.1262496

IZ

https://izlik.org/JA65GA86WF

Kaynak Göster

RIS / Bibtex

APA

Ekici, H., Ökmen, F., Gül Sarıtaş, D., İmamoğlu, M., Eker, T., & Ergenoğlu, A. (2023). Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes. Ege Tıp Dergisi, 62(1), 74-80. https://doi.org/10.19161/etd.1262496

AMA

1.Ekici H, Ökmen F, Gül Sarıtaş D, İmamoğlu M, Eker T, Ergenoğlu A. Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes. ETD. 2023;62(1):74-80. doi:10.19161/etd.1262496

Chicago

Ekici, Hüseyin, Fırat Ökmen, Didem Gül Sarıtaş, Metehan İmamoğlu, Turnagül Eker, ve Ahmet Ergenoğlu. 2023. “Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes”. Ege Tıp Dergisi 62 (1): 74-80. https://doi.org/10.19161/etd.1262496.

EndNote

Ekici H, Ökmen F, Gül Sarıtaş D, İmamoğlu M, Eker T, Ergenoğlu A (01 Mart 2023) Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes. Ege Tıp Dergisi 62 1 74–80.

IEEE

[1]H. Ekici, F. Ökmen, D. Gül Sarıtaş, M. İmamoğlu, T. Eker, ve A. Ergenoğlu, “Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes”, ETD, c. 62, sy 1, ss. 74–80, Mar. 2023, doi: 10.19161/etd.1262496.

ISNAD

Ekici, Hüseyin - Ökmen, Fırat - Gül Sarıtaş, Didem - İmamoğlu, Metehan - Eker, Turnagül - Ergenoğlu, Ahmet. “Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes”. Ege Tıp Dergisi 62/1 (01 Mart 2023): 74-80. https://doi.org/10.19161/etd.1262496.

JAMA

1.Ekici H, Ökmen F, Gül Sarıtaş D, İmamoğlu M, Eker T, Ergenoğlu A. Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes. ETD. 2023;62:74–80.

MLA

Ekici, Hüseyin, vd. “Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes”. Ege Tıp Dergisi, c. 62, sy 1, Mart 2023, ss. 74-80, doi:10.19161/etd.1262496.

Vancouver

1.Hüseyin Ekici, Fırat Ökmen, Didem Gül Sarıtaş, Metehan İmamoğlu, Turnagül Eker, Ahmet Ergenoğlu. Primary autoimmune thrombocytopenia in pregnancy: maternal and neonatal outcomes. ETD. 01 Mart 2023;62(1):74-80. doi:10.19161/etd.1262496