Araştırma Makalesi

Hashimoto's encephalopathy presenting with unusual clinical findings in pediatric population: revision of the diagnostic criteria

Cilt: 62 Sayı: 3 18 Eylül 2023
  • Hande Gazeteci Tekin
  • Sanem Yilmaz
  • Murat Ayar *
  • Pınar Edem
  • Hasan Tekgul
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Hashimoto's encephalopathy presenting with unusual clinical findings in pediatric population: revision of the diagnostic criteria

Abstract

Aim: Hashimoto's encephalopathy is a rare progressive and relapsing disease of presumed autoimmune origin associated with high titers of thyroid antibodies. Also named steroid-responsive encephalopathy, the disease can be cured with early treatment. Hashimoto's encephalopathy may occur with various clinical manifestations, but it often presents with symptoms such as seizures, confusion, hallucination, sleep abnormalities, and behavioural problems. Patients are mostly euthyroid or mildly hypothyroid. Hashimoto encephalopathy is a controversial diagnosis for misdiagnosis and overdiagnosis because of the high prevalence of thyroid antibodies in the population. Therefore, this diagnosis requires strict criteria that can highly indicate the diagnosis. We aimed to present the diagnosis and treatment processes from unusual symptoms of patients who are considered to have Hashimoto's encephalopathy with very strict criteria. Materials and Methods: Here we present five pediatric patients diagnosed with Hashimoto's encephalopathy between 2013 and 2023. The clinical signs and symptoms, laboratory findings, treatment options and response to treatment were obtained from patient records retrospectively. Results: On admission, patients had striking behavioural changes such as hallucinations, insomnia, purposeless laughing as well as signs of encephalopathy such as status epilepticus and confusion; neurological sequelae; history of surgery, and fever. All patients had high levels of thyroid antibodies and they responded perfectly to steroid treatment in a short period of time. Conclusion: Hashimoto’s encephalopathy should be considered in all patients presenting with encephalopathy in the pediatric age group. These patients may have unusual and clinical manifestations.

Keywords

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Çocuk Nörolojisi

Bölüm

Araştırma Makalesi

Yazarlar

Hande Gazeteci Tekin
Türkiye

Sanem Yilmaz
Türkiye

Pınar Edem
Türkiye

Hasan Tekgul
Türkiye

Yayımlanma Tarihi

18 Eylül 2023

Gönderilme Tarihi

15 Şubat 2023

Kabul Tarihi

1 Mayıs 2023

Yayımlandığı Sayı

Yıl 2023 Cilt: 62 Sayı: 3

DOI

https://doi.org/10.19161/etd.1360751

IZ

https://izlik.org/JA88DR74LA

Kaynak Göster

RIS / Bibtex
Vancouver
1.Hande Gazeteci Tekin, Sanem Yilmaz, Murat Ayar, Pınar Edem, Hasan Tekgul. Hashimoto’s encephalopathy presenting with unusual clinical findings in pediatric population: revision of the diagnostic criteria. ETD. 01 Eylül 2023;62(3):432-9. doi:10.19161/etd.1360751

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